Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity [0.03%]
低脂肪瘦肉摄入可独立于餐后循环蛋白组分来增加肥胖年轻成人肌肉肌醇六磷酸激酶1含量
Richie D Barclay,Joseph W Beals,Jenny Drnevich et al.
Richie D Barclay et al.
Background: We have recently shown that a novel signalling kinase, inositol hexakisphosphate kinase 1 (IP6K1), is implicated in whole-body insulin resistance via its inhibitory action on Akt. Insulin and insulin like grow...
Controlled Clinical Trial
Metabolism: clinical and experimental. 2020 Jan:102:153996. DOI:10.1016/j.metabol.2019.153996
Effects of newer antidiabetic drugs on nonalcoholic fatty liver and steatohepatitis: Think out of the box! [0.03%]
新型降糖药物对非酒精性脂肪肝和脂肪性肝炎影响的研究：跳出思维定势！
Golnaz Ranjbar,Dimitri P Mikhailidis,Amirhossein Sahebkar
Golnaz Ranjbar
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western societies and a major cause of hepatic disease worldwide. Its more severe type, namely nonalcoholic steatohepatitis (NASH), may result in the devel...
Simon N Dankel,Therese H Røst,Agné Kulyté et al.
Simon N Dankel et al.
Background: Adipose tissue plays a crucial role in diet- and obesity-related insulin resistance, with implications for several metabolic diseases. Identification of novel target genes and mechanisms that regulate adipocyt...
Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials [0.03%]
胃肠道激素在最常见的减肥手术后的循环水平及一年减重的预测价值：两项独立研究的证据
Nikolaos Perakakis,Alexander Kokkinos,Natia Peradze et al.
Nikolaos Perakakis et al.
Aims: Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal hormones are involved in energy and glucose homeostasis, thus postoperative changes of their circulating levels may be mediating futu...
SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders [0.03%]
激活SIRT1可纠正遗传性维生素B₁₂缺乏病引起的RNA结合蛋白定位异常及认知缺陷
Rose Ghemrawi,Carole Arnold,Shyue-Fang Battaglia-Hsu et al.
Rose Ghemrawi et al.
Background: The molecular consequences of inborn errors of vitamin B12 or cobalamin metabolism are far from being understood. Moreover, innovative therapeutic strategies are needed for the treatment of neurological outcom...
Clinical usefulness of human serum nonmercaptalbumin to mercaptalbumin ratio as a biomarker for diabetic complications and disability in activities of daily living in elderly patients with diabetes [0.03%]
人血清非巯基白蛋白与巯基白蛋白比值用作糖尿病并发症和老年人日常生活能力残疾的生物标志物的临床效用
Saki Fukuhara,Keiko Yasukawa,Masaya Sato et al.
Saki Fukuhara et al.
Background: Oxidative stress may play an important role in the development of diabetic complications. The ratio of human nonmercaptalbumin (HNA; oxidized form) to human mercaptalbumin (HMA; reduced form) has attracted att...
Bradley Tucker,Huating Li,Xiaoxue Long et al.
Bradley Tucker et al.
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies ranging from uncomplicated hepatic fat accumulation to a state of lobular inflammation and hepatocyte ballooning, known as non-alcoholic steatohepatitis (NASH)....
Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats [0.03%]
大鼠肝原位肝瘤中丙酮酸脱氢酶活性增高与糖异生障碍并存的现象
Min Hee Lee,Ralph J DeBerardinis,Xiaodong Wen et al.
Min Hee Lee et al.
Background: Therapies targeting altered activity of pyruvate dehydrogenase (PDH) and pyruvate carboxylase (PC) have been proposed for hepatomas. However, the activities of these pathways in hepatomas in vivo have not been...
Supervised lifestyle intervention for people with metabolic syndrome improves outcomes and reduces individual risk factors of metabolic syndrome: A systematic review and meta-analysis [0.03%]
针对代谢综合征患者的强化生活方式干预改善预后并降低个体代谢综合征组分的危险因素：系统综述和meta分析
Maria van Namen,Luke Prendergast,Casey Peiris
Maria van Namen
Background: Metabolic syndrome is characterised by a clustering of metabolic risk factors including abdominal obesity, raised triglycerides, lowered HDL cholesterol, hypertension and impaired glucose tolerance. Multifacet...
Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men [0.03%]
日本男性糖尿病前期及冠心病与冠状动脉疾病风险的关系
Masaru Kitazawa,Kazuya Fujihara,Taeko Osawa et al.
Masaru Kitazawa et al.
Objective: Although glucose abnormality status (GAS), prior coronary artery disease (CAD), and other traditional risk factors affect the incidence of subsequent CAD, their impact in the same cohort has been scantly studie...