Insulin regulation of vessel wall function and hypertension in the metabolic syndrome; from bench to bedside and back again Revisiting the work of Dr. James R. Sowers [0.03%]
代谢综合征中胰岛素调节血管壁功能及高血压；从实验台到病床再回来 重新审视James R. Sowers博士的工作
Adam Whaley-Connell,Guanghong Jia,Annayya R Aroor et al.
Adam Whaley-Connell et al.
Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction [0.03%]
Eva1缺陷通过减少内脏脂肪组织功能障碍来预防肥胖诱导的代谢紊乱
You Lee Son,Jiahui Hou,Mira Kato-Suzuki et al.
You Lee Son et al.
Aims: Epithelial V-like antigen 1 (Eva1) is a highly specific marker for brown adipose tissue (BAT) in both mice and humans, but its metabolic function remains unclear. We investigated the impact of Eva1 deletion on the d...
Turning sour into sweet: Lactylation modification as a promising target in cardiovascular health [0.03%]
化苦为甜：乳酰化修饰作为心血管健康中一个有前景的靶点
Yajie Liao,Liyan Niu,Jitao Ling et al.
Yajie Liao et al.
Lactylation, a recently identified posttranslational modification (PTM), has emerged as a critical regulatory mechanism in cardiovascular diseases (CVDs). This PTM involves the addition of lactyl groups to lysine residues on histones and no...
Prolonged increase in glutamate whole body and intracellular production in older adults with COPD and healthy controls post-resistance exercise [0.03%]
慢性阻塞性肺病患者和健康对照组在抗阻力运动后整个身体和细胞内谷氨酸产量持续增加的研究
Robert H Mbilinyi,Nicolaas E P Deutz,Clayton L Cruthirds et al.
Robert H Mbilinyi et al.
Background: Exercise training is essential for pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD), yet patient responsiveness varies widely. We previously observed metabolic disturbances in amino aci...
A multi-metabolite signature robustly predicts long-term mortality in the PREDIMED trial and several US cohorts [0.03%]
在PREDIMED试验和几个美国队列中，一个多代谢物标志物可稳健地预测长期死亡率
Gonzalo Fernández-Duval,Cristina Razquin,Fenglei Wang et al.
Gonzalo Fernández-Duval et al.
Metabolome-based biomarkers contribute to identify mechanisms of disease and to a better understanding of overall mortality. In a long-term follow-up subsample (n = 1878) of the PREDIMED trial, among 337 candidate baseline plasma metabolite...
LINC00278 and BRG1: A key regulatory axis in male obesity and preadipocyte adipogenesis [0.03%]
LINC00278和BRG1：男性肥胖及前脂肪细胞脂肪生成的关键调控轴
Tongtong Zhang,Zhengyun Ren,Rui Mao et al.
Tongtong Zhang et al.
Obesity is a significant public health concern directly associated with adipogenesis. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of adipogenesis. However, the roles of sex-specific lncRNAs in adipose tissue are not w...
Defining lipedema's molecular hallmarks by multi-omics approach for disease prediction in women [0.03%]
利用多组学方法定义女性脂肪水肿的分子特征以预测疾病
Leon G Straub,Jan-Bernd Funcke,Nolwenn Joffin et al.
Leon G Straub et al.
Lipedema is a chronic disease in females characterized by pathologic subcutaneous adipose tissue expansion and hitherto remains without druggable targets. In this observational study, we investigated the molecular hallmarks of lipedema usin...
Pharmacologically targeting fatty acid synthase-mediated de novo lipogenesis alleviates osteolytic bone loss by directly inhibiting osteoclastogenesis through suppression of STAT3 palmitoylation and ROS signaling [0.03%]
通过抑制STAT3的棕榈酰化及ROS信号直接抑制破骨细胞生成从而缓解骨溶解性骨质流失——药理学上针对脂肪酸合成酶介导的从头脂质生成的新疗法
Chunmei Xiu,Lei Zhang,Chenxi Zhang et al.
Chunmei Xiu et al.
Aberrant increases in osteoclast formation and/or activity are the underlying cause of bone loss in a variety of osteolytic diseases. Fatty acid synthase (Fasn)-mediated de novo lipogenesis (DNL) is one of the major lipid metabolic pathways...
Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts [0.03%]
肉类摄入的血浆代谢物概况及其与心血管疾病风险的关联性：瑞典人群队列中的群体研究
Getachew Arage,Koen F Dekkers,Luka Marko Rašo et al.
Getachew Arage et al.
Background: Higher meat intake has been associated with adverse health outcomes, including cardiovascular disease (CVD). This study investigated plasma metabolites associated with meat intake and their relation with cardi...
Metabolic dysfunction-associated steatotic liver disease: A sexually dimorphic disease and breast and gynecological cancer [0.03%]
与代谢功能障碍相关的脂肪性肝病：一种具有性别差异的疾病和乳腺及妇科癌症的关系
Xinrong Zhang,Mindie H Nguyen
Xinrong Zhang
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a global public health and economic burden worldwide in the past few decades. Epidemiological studies have shown that MASLD is a multisystem disease that is associa...