Targeting lipid metabolism in neurodegenerative diseases: From experimental to clinical [0.03%]
脂质代谢在神经退行性疾病中的作用：从实验到临床
Junpeng Long,Shasha Liu,Yaning Shi et al.
Junpeng Long et al.
The human brain, despite accounting for only 2 % of total body weight, exhibits an exceptionally high lipid content (approximately 20 % of its mass), highlighting the critical role of lipid metabolism in maintaining neural homeostasis and f...
BCAA catabolism in TRH neurons of paraventricular nucleus regulates energy expenditure [0.03%]
下丘脑室旁核TRH神经元中的支链氨基酸分解代谢调控能量消耗
Xing Ming,Jialin Tan,Miaomiao Yuan et al.
Xing Ming et al.
The role of hypothalamic branched-chain amino acid (BCAA) catabolism in the maintenance of energy homeostasis remains elusive. By using Mendelian randomization, we found that genetically predicted branched-chain keto acid dehydrogenase E1α...
Calcitonin and procalcitonin: Revisiting the overlooked role of C cells [0.03%]
重访被忽视的C细胞作用——降钙素和前降钙素的作用
Eleonore Fröhlich,Richard Wahl
Eleonore Fröhlich
Calcitonin (CT) is a hormone produced by C cells in the thyroid gland. Its primary function is to regulate bone turnover. However, it is believed to be of little importance to human physiology because its absence following thyroidectomy has...
GLP-1RAs and tirzepatide may reduce heart failure risk in obese but not in non-obese patients with cardiovascular or renal disease: A systematic review and meta-analysis [0.03%]
GLP-1受体激动剂和Tirzepatide可能降低肥胖但不降低非肥胖心血管或肾脏疾病患者的心力衰竭风险：系统评价和meta分析
Ju Zhang,Xiangfeng Guan,Mowei Kong et al.
Ju Zhang et al.
Background: Cardiovascular disease (CVD) and chronic kidney disease (CKD) frequently coexist, with obesity and type 2 diabetes (T2D) being major contributors to adverse outcomes. Glucagon-like peptide-1 receptor agonists ...
Daosheng Ai,Baoshan Qiu,Xing-Jun Chen et al.
Daosheng Ai et al.
Acute ischemic stroke (AIS) is a leading causes of mortality and disability globally. Despite its complex pathological mechanisms, effective neuroprotective strategies are still lacking in clinical practice. Microglia and their metabolic pr...
Serotonin 2C receptors inhibit hypothalamic CRH neurons to suppress appetite [0.03%]
5-羟色胺2C受体通过抑制下丘脑CRH神经元来抑制食欲
Eun-Seon Yoo,Jieun Yu,Moonsun Sa et al.
Eun-Seon Yoo et al.
Objectives: The serotonin 2C receptor (Htr2c) is one of the plausible targets for the development of appetite suppressants. Previous studies have demonstrated the complexity of neuronal circuitry underlying the appetite-s...
Sphk2 suppresses ferroptosis in ischemic hearts by promoting HSP90AA1-mediated TFEB nuclear translocation, lysosome biogenesis and lysosome-autophagy pathway-dependent lipid-ROS clearance [0.03%]
Sphk2通过促进HSP90AA1介导的TFEB核转位、溶酶体生物发生和溶酶体自噬途径依赖性脂质ROS清除来抑制缺血心脏中铁死亡发生
Ting Gong,Danru Wang,Yawei Jin et al.
Ting Gong et al.
Background: Lipid peroxidation and iron overload-mediated cardiac ferroptosis play a critical role in myocardial ischemic injury and remodeling. Sphingosine kinase 2 (Sphk2) is implicated in lipid metabolism and cell surv...
SLC22A6-dependent lactylation of H3K9 aggravates endothelial dysfunction and atherosclerosis [0.03%]
依赖于SLC22A6的H3K9乳酰化加重内皮功能障碍和动脉粥样硬化
Yuting Ma,Sunye Feng,Yujie Jiang et al.
Yuting Ma et al.
Background: Atherosclerosis, a leading cause of cardiovascular morbidity and mortality, is driven by endothelial dysfunction. While metabolic reprogramming toward glycolysis in endothelial cells exacerbates disease progre...
Lifestyle intervention is more effective in high 1-hour post-load glucose than in prediabetes for restoring β-cell function, reducing ectopic fat, and preventing type 2 diabetes [0.03%]
生活干预在1小时高血糖状态比在糖尿病前期状态下更有效地恢复胰岛β细胞功能、减少代谢异常脂肪沉积以及预防2型糖尿病患者
Yiying Wang,Arvid Sandforth,Reiner Jumpertz- von Schwartzenberg et al.
Yiying Wang et al.
Background: High 1-h-post-load plasma glucose (1 h-PG) is an early diabetes risk marker. We hypothesized that isolated high 1 h-PG represents an intermediate state between normal glucose regulation (NGR) and impaired gluc...
Hepatic steatosis associates with leukopoietic activity and atherosclerotic inflammation: mechanistic insights into cardiovascular risk [0.03%]
肝脂肪变性与髓系活性和动脉粥样硬化炎症相关：心血管风险的机制研究见解
Shady Abohashem,Wesam Aldosoky,Taimur Abbasi et al.
Shady Abohashem et al.
Background: Hepatic steatosis (HS) is associated with an increased risk of major adverse cardiovascular events (MACE). However, the underlying mechanisms linking HS to MACE remain incompletely understood. This study aimed...