Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19 [0.03%]
评论：磷酸二酯酶4抑制剂有望成为针对新冠肺炎细胞因子风暴的辅助治疗药物
Maria Dalamaga,Irene Karampela,Christos S Mantzoros
Maria Dalamaga
The most severe presentation of COVID-19 is characterized by a hyperinflammatory state attributed to the massive pro-inflammatory cytokine release, called "cytokine storm". Several specific anti-inflammatory/immunosuppressive agents are bei...
Letter to the Editor: Non-specific effects resulting from use of tocilizumab in mice [0.03%]
致编辑信件：托珠单抗在小鼠中的非特异性效应
Juliane Lokau,Georg H Waetzig,Stefan Rose-John et al.
Juliane Lokau et al.
GATA3 induces the upregulation of UCP-1 by directly binding to PGC-1α during adipose tissue browning [0.03%]
GATA3通过直接结合PGC-1α促进脂肪组织褐变过程中UCP-1的上调表达
Min Jeong Son,Kyoung-Jin Oh,Anna Park et al.
Min Jeong Son et al.
Objective: Obesity is recognized as the cause of multiple metabolic diseases and is rapidly increasing worldwide. As obesity is due to an imbalance in energy homeostasis, the promotion of energy consumption through browni...
M Chakhtoura,N Napoli,G El Hajj Fuleihan
M Chakhtoura
Commentary: Glucose control: Not just a bystander in GLP-1RA-mediated cardiovascular protection [0.03%]
述评：血糖控制并非GLP-1受体激动剂心血管保护作用的“局外人”
Irene Caruso,Angelo Cignarelli,Annalisa Natalicchio et al.
Irene Caruso et al.
Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis [0.03%]
降糖药与痴呆风险的关系：贝叶斯网状meta分析研究
Jian-Bo Zhou,Xingyao Tang,Min Han et al.
Jian-Bo Zhou et al.
Background: Dementia is more prevalent among people with type 2 diabetes, but little is known regarding the influence of antidiabetic agents on this association. ...
Multi-year reproducibility of hyperinsulinemic euglycemic clamp-derived insulin sensitivity in free-living adults: Association with incident prediabetes in the POP-ABC study [0.03%]
基于POP-ABC研究的高胰岛素正常血糖钳夹法衍生的胰岛素敏感性在社区成年人群中的长期稳定性及其与新发糖尿病前期的关系
Deirdre James,Nkiru Umekwe,Chimaroke Edeoga et al.
Deirdre James et al.
Objective: The hyperinsulinemic euglycemic clamp (HEC) is the "gold standard" for measuring insulin sensitivity (Si-clamp). Here, we determined the reproducibility of serial HEC data in healthy subjects. ...
Argyro Panagiotakou,Maria Yavropoulou,Narjes Nasiri-Ansari et al.
Argyro Panagiotakou et al.
Bisphosphonates (BPs) are pyrophosphate analogues widely used in diseases related to bone loss and increased bone turnover. Their high affinity for bone hydroxyapatite makes them ideal agents for bone diseases, while preventing them from re...
Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York [0.03%]
肥胖、年龄增大和男性性别分别与COVID-19患者的不良住院结局和较高的病死率相关：纽约市布朗克斯地区COVID-19患者队列研究
Leonidas Palaiodimos,Damianos G Kokkinidis,Weijia Li et al.
Leonidas Palaiodimos et al.
Background & aims: New York is the current epicenter of Coronavirus disease 2019 (COVID-19) pandemic. The underrepresented minorities, where the prevalence of obesity is higher, appear to be affected disproportionately. O...
Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens? [0.03%]
铁螯合剂有可能成为新冠肺炎治疗的辅助用药吗？
Maria Dalamaga,Irene Karampela,Christos S Mantzoros
Maria Dalamaga
The pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to global health. Currently, no specific prophylactic and therapeutic treatment is available. No evidence from random...