Letter to the editor: Immunomodulation by phosphodiesterase-4 inhibitor in COVID-19 patients [0.03%]
读者来信：磷酸二酯酶-4抑制剂在治疗新冠肺炎患者的免疫调节作用
Alessandro Santaniello,Barbara Vigone,Lorenzo Beretta
Alessandro Santaniello
Metabolic liver disease in diabetes - From mechanisms to clinical trials [0.03%]
糖尿病中的代谢性肝病-从机制到临床试验
Bedair Dewidar,Sabine Kahl,Kalliopi Pafili et al.
Bedair Dewidar et al.
Non-alcoholic fatty liver disease (NAFLD) comprises fatty liver (steatosis), non-alcoholic steatohepatitis (NASH) and fibrosis/cirrhosis and may lead to end-stage liver failure or hepatocellular carcinoma. NAFLD is tightly associated with t...
Population insulin sensitivity from sparsely sampled oral glucose tolerance tests [0.03%]
稀疏采集口服葡萄糖耐量试验数据的群体胰岛素敏感性评估模型
Darko Stefanovski,Priyathama Vellanki,Dawn D Smiley-Byrd et al.
Darko Stefanovski et al.
Objective: This work aimed to estimate population-level insulin sensitivity (SI) from 2-hour oral glucose tolerance tests (OGTT) with less than 7 samples. ...
ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death [0.03%]
APOC2缺陷诱发重度高甘油三酯血症和自发性动脉粥样硬化：一个被解救的致死性新生鼠模型
Mingming Gao,Chun Yang,Xiaowei Wang et al.
Mingming Gao et al.
Rationale: ApoC2 is an important activator for lipoprotein lipase-mediated hydrolysis of triglyceride-rich plasma lipoproteins. ApoC2-deficient patients display severe hypertriglyceridemia (sHTG) and recurrent acute pancr...
Sudhir Kumar Rai,Fernando Bril,Heather M Hatch et al.
Sudhir Kumar Rai et al.
Background: Pheochromocytomas (PCCs) and paragangliomas (PGLs) are neuroendocrine tumors that are mostly benign. Metastatic disease does occur in about 10% of cases of PCC and up to 25% of PGL, and for these patients no e...
The efficacy and safety of dipeptidyl peptidase-4 inhibitors compared to other oral glucose-lowering medications in the treatment of type 2 diabetes [0.03%]
二肽基肽酶-4抑制剂与其他口服降糖药物治疗2型糖尿病的疗效和安全性比较
Anca Pantea Stoian,Alexandros Sachinidis,Roxana Adriana Stoica et al.
Anca Pantea Stoian et al.
Introduction: The dipeptidyl peptidase-4 inhibitors (DPP-4is), which belong to the class of incretin-based medications, are recommended as second or third-line therapies in guidelines for the management of type 2 diabetes...
A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism [0.03%]
新生儿脐带血出生体重的多组学分析揭示了胆固醇代谢相关的新机制
Rossella Alfano,Marc Chadeau-Hyam,Akram Ghantous et al.
Rossella Alfano et al.
Background: Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains...
Changing trends of liver transplantation and mortality from non-alcoholic fatty liver disease [0.03%]
肝脏移植和非酒精性脂肪肝病死亡率的变化趋势
Avik Majumdar,Emmanuel A Tsochatzis
Avik Majumdar
The rising tide of non-alcoholic fatty liver disease (NAFLD) associated with the obesity epidemic is a major international health concern. NAFLD is the leading global cause of liver disease with an estimated prevalence of 25% and is the fas...
Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion [0.03%]
MOF通过改变不同的α细胞亚群质量和类岛glucagon样肽-1、胰高血糖素分泌来调节葡萄糖水平
Xinghong Guo,Danyang Li,Jia Song et al.
Xinghong Guo et al.
Background: Males absent on the first (Mof) is implicated in gene control of diverse biological processes, such as cell growth, differentiation, apoptosis and autophagy. However, the relationship between glucose regulatio...
Fortifying diet with rapeseed oil instead of butterfat attenuates the progression of diet-induced non-alcoholic fatty liver disease (NAFLD) and impairment of glucose tolerance [0.03%]
用芥花油强化饮食可替代黄油脂肪,以减缓饮食诱导的非酒精性脂肪肝病(NAFLD)和糖耐量损伤的发展进程
Annette Brandt,Dragana Rajcic,Cheng Jun Jin et al.
Annette Brandt et al.
Background: Absolute dietary fat intake but even more so fatty acid pattern is discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). Here, we determined if switching a butterfat enriche...