The role of visceral adiposity in the severity of COVID-19: Highlights from a unicenter cross-sectional pilot study in Germany [0.03%]
德国单中心横断面试点研究中关于腹腔内脂肪堆积在新冠肺炎严重程度中作用的亮点分析
Antonia Petersen,Keno Bressem,Jakob Albrecht et al.
Antonia Petersen et al.
Background and aims: Overall obesity has recently been established as an independent risk factor for critical illness in patients with coronavirus disease 2019 (COVID-19). The role of fat distribution and especially that ...
commentary: COVID-19 and Obesity: Exploring Biologic Vulnerabilities, Structural Disparities, and Weight Stigma [0.03%]
评论：新冠肺炎与肥胖：探索生物学脆弱性、结构差异及体重歧视
Matthew J Townsend,Theodore K Kyle,Fatima Cody Stanford
Matthew J Townsend
Commentary: From mice to men: In search for dietary interventions to form the background on which pharmacotherapy for non-alcoholic fatty liver disease should be based [0.03%]
述评：从老鼠到人类——寻找基于饮食干预的非酒精性脂肪肝药物治疗研究背景
Emir Muzurović,Dimitri P Mikhailidis,Christos Mantzoros
Emir Muzurović
Legacy effect of intensive glucose control on major adverse cardiovascular outcome: Systematic review and meta-analyses of trials according to different scenarios [0.03%]
强化血糖控制对主要不良心血管结局的长期影响：不同情境下的系统综述和meta分析
Francesco Prattichizzo,Paola de Candia,Valeria De Nigris et al.
Francesco Prattichizzo et al.
Background: Early and intensive glycaemic control provides long-term protection against the development of microvascular complications, a phenomenon defined legacy effect. Whether a legacy effect of high glucose exists al...
Defects in High Density Lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of Hepatocyte Nuclear Factor 4A [0.03%]
肝细胞核因子4A肝特异性缺陷小鼠高密度脂蛋白代谢及肝脏脂变异常研究
Efstathia Thymiakou,Alaa Othman,Thorsten Hornemann et al.
Efstathia Thymiakou et al.
Background: Aberrant concentration, structure and functionality of High Density Lipoprotein (HDL) are associated with many prevalent diseases, including cardiovascular disease and non-alcoholic fatty liver disease (NAFLD)...
SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes [0.03%]
SLC46A1通过在肝细胞中转运血红素参与铁代谢
Hongxia Li,Dongyao Wang,Huiwen Wu et al.
Hongxia Li et al.
Background: Iron is finely regulated due to its vital roles in organisms and the peroxidase reactivity if excess. Solute Carrier Family 46 Member 1 (SLC46A1), also named PCFT or HCP1, is the main importer of heme‑iron in...
Early adaptive thermogenesis is a determinant of weight loss after six weeks of caloric restriction in overweight subjects [0.03%]
过度体重者六周热量限制减肥过程中早期适应性产热是决定减重结果的重要因素
Sascha Heinitz,Tim Hollstein,Takafumi Ando et al.
Sascha Heinitz et al.
Background: Adaptive thermogenesis during prolonged energy deficit refers to the greater than expected reduction in energy expenditure (EE) independent of concomitant loss of metabolically active body mass. ...
Functional loss of pancreatic islets in type 2 diabetes: How can we halt it? [0.03%]
2型糖尿病下的胰岛功能丧失：我们如何才能阻止它？
Nicola Marrano,Giuseppina Biondi,Angelo Cignarelli et al.
Nicola Marrano et al.
The loss of beta-cell functional mass is a necessary and early condition in the development of type 2 diabetes (T2D). In T2D patients, beta-cell function is already reduced by about 50% at diagnosis and further declines thereafter. Beta-cel...
Ubiquitination of PPAR-gamma by pVHL inhibits ACLY expression and lipid metabolism, is implicated in tumor progression [0.03%]
泛素连接酶pVHL通过泛素化PPAR-γ抑制ACLY表达及脂代谢，促进肿瘤进展
Kyung Hee Noh,Hyun Mi Kang,Wonbeak Yoo et al.
Kyung Hee Noh et al.
Background: Intracellular lipid accumulation is associated with various diseases, particularly cancer. Mitochondrial dysfunction is considered as a cause of lipid accumulation; however, the related underlying mechanism re...
Letter to the editor: Unexpected high mortality in COVID-19 and diabetic ketoacidosis [0.03%]
读者来信：COVID-19和糖尿病酮症酸中毒导致的高死亡率
Natalia Chamorro-Pareja,Sahana Parthasarathy,Jayabhargav Annam et al.
Natalia Chamorro-Pareja et al.