Unraveling sphingolipid complexity in liver fibrosis: Perspectives for future research [0.03%]
鞘脂类在肝纤维化中的复杂性及其未来研究方向展望
Jiaqi Wei,Yaohui Zhong,Yaling Li et al.
Jiaqi Wei et al.
A complex multisystem disorder including hypopituitarism and hypoparathyroidism, associated with mutation in the gene encoding fatty acid synthase (FASN) [0.03%]
编码脂肪酸合酶(FASN)基因突变相关的复杂多系统疾病，包括垂体激素缺乏和甲状旁腺激素缺乏
L C Gregory,S Krywawych,S Rahman et al.
L C Gregory et al.
Whole exome sequencing performed on a male patient with a complex phenotype including short stature associated with hypopituitarism, sensorineural deafness, hypoparathyroidism, retinal dystrophy, and developmental delay revealed a novel de ...
Prevention of insulin-induced lipohypertrophy by coadministration of a low dose of high-affinity PI3K inhibitors [0.03%]
胰岛素诱导的皮下脂肪肥大模型中高亲和力PI3K抑制剂低剂量共给药的预防作用研究
Barbara Becattini,Andrea Usseglio Gaudi,Per-Anders Jansson et al.
Barbara Becattini et al.
Background: Insulin-induced lipohypertrophy (ILH) is the most frequent injection site side effect of insulin therapy. ILH consists of local adipose tissue overgrowth at the insulin injection site that eventually progresse...
L-Kynurenine activates the AHR-PCSK9 pathway to mediate the lipid metabolic and ovarian dysfunction in polycystic ovary syndrome [0.03%]
L-瓜氨酸激活AHR-PCSK9通路介导多囊卵巢综合征脂代谢及卵巢功能障碍的作用机制研究
Yujiao Wang,Yifan Wu,Hongwei Jiang et al.
Yujiao Wang et al.
Dysregulated amino acid metabolism is a key contributor to polycystic ovary syndrome (PCOS). This cross-sectional study revealed that serum levels of L-kynurenine (L-Kyn) were significantly elevated in women with PCOS, whereas pyridoxal 5'-...
Metabolic dysfunction-associated steatotic liver disease and malignancies: Unmasking a silent saboteur [0.03%]
与代谢功能障碍相关的脂肪肝疾病和恶性肿瘤：揭开一个隐形破坏者的真实面目
Stergios A Polyzos,Christos S Mantzoros
Stergios A Polyzos
Not required for Editorials. Keywords: Cancer; Malignancy; Metabolic dysfunction-associated steatohepatitis;...
Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial [0.03%]
活性维生素D通过调节人体骨骼肌的合成代谢和分解代谢信号通路对抗肌肉减少症的效果：一项随机对照试验
Tetsuya Kawahara,Tetsuya Inazu,Shoichi Mizuno et al.
Tetsuya Kawahara et al.
Background: The muscle-building and strengthening effects of the active form of vitamin D in humans remain unclear. Methods: In this an...
Landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue: a systematic review and meta-analysis of transcriptomics studies [0.03%]
皮下脂肪组织中肥胖和二型糖尿病性别差异的景观：一项转录组研究的系统评价和荟萃分析
Roxana Andreea Moldovan,Marta R Hidalgo,Helena Castañé et al.
Roxana Andreea Moldovan et al.
Obesity represents a significant risk factor in the development of type 2 diabetes (T2D), a chronic metabolic disorder characterized by elevated blood glucose levels, and a previous step for its development. Significant sex differences have...
C-C motif chemokines ligand 7 contributes to metabolic dysfunction-associated steatotic liver disease by enabling redox-sensitive induction of hypermethylated in cancer 1 [0.03%]
C-C基序趋化因子7通过激活癌症中超甲基化的1号红氧敏感诱导物，促进代谢功能障碍相关的大泡性肝病
Xinyue Sun,Jinge Wu,Huiqian Lv et al.
Xinyue Sun et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a global pandemic and the most critical implication for liver transplantation. In the present study, we investigated the role of CC motif chemokine ligand 7 (CCL7) ...
The serine protease KLK7 promotes immune cell infiltration in visceral adipose tissue in obesity [0.03%]
丝氨酸蛋白酶KLK7促进肥胖内脏脂肪组织中的免疫细胞浸润
Aleix Ribas-Latre,Anne Hoffmann,Claudia Gebhardt et al.
Aleix Ribas-Latre et al.
Obesity is a major health problem associated with global metabolic dysfunction and increased inflammation. It is thus critical to identify the mechanisms underlying the crosstalk between immune cells and adipose tissue that drive cardiovasc...
Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver [0.03%]
空间脂质组学揭示了肝纤维化的抗纤维化靶标-神经酰胺代谢
Aleksandra Gruevska,Jack Leslie,Elena Perpin Án et al.
Aleksandra Gruevska et al.
Background and aims: Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding the specific mechanisms of lipotoxicity, dysregulate...