TMEM41B contributes to atherosclerosis by promoting lipid synthesis in vascular smooth muscle cells via fatty acid synthase stabilization [0.03%]
TMEM41B通过稳定脂肪酸合成酶促进血管平滑肌细胞脂质合成从而促动脉粥样硬化进展
Gui-Yan Peng,Li-Tai Wei,Ye-Xiang Jing et al.
Gui-Yan Peng et al.
Foam cell formation has traditionally been attributed to macrophages; however, emerging evidence highlights vascular smooth muscle cells (VSMCs) as another significant contributor. Here, we found that TMEM41B is significantly upregulated in...
Metabolic reprogramming in diabetic foot ulcers: mechanisms, therapeutic implications and future perspectives [0.03%]
糖尿病足溃疡中的代谢重组：机制、治疗意义及未来展望
Li Jinyi,Ding Xianguang,Ding Yuhan et al.
Li Jinyi et al.
As a devastating complication, diabetic foot ulcer (DFU) is characterized by chronic, nonhealing wounds due to vasculopathy and neuropathy. It has emerged as a most challenging chronic disease worldwide, affecting millions of people worldwi...
Prenatal caffeine exposure impairs neurodevelopment via glucocorticoid-driven epigenetic cascade suppressing astrocytic ABCG1 and cholesterol transport [0.03%]
宫内咖啡因暴露通过糖皮质激素诱导的表观遗传级联反应抑制星形胶质细胞ABCG1和胆固醇运输从而影响神经发育
Gaole Dai,Mingcui Luo,Shiyun Dai et al.
Gaole Dai et al.
Prenatal caffeine exposure (PCE), stemming from widespread maternal intake of caffeine-containing substances, has emerged as a major pharmacological stressor affecting fetal neurodevelopment. Although epidemiological studies have consistent...
Sibo Wang,Qian Ren,Yansheng Huang et al.
Sibo Wang et al.
Arginine, as a semi-essential amino acid, plays a pivotal role in bone metabolism and orthopedic diseases. Beyond its function in protein synthesis, arginine serves as a crucial precursor for Nitric Oxide (NO), polyamines, and proline, prof...
Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study [0.03%]
空气污染通过共享的基因-表观遗传机制加剧心血管-肾脏-代谢综合征和肌少症共病：一项多组学和孟德尔随机化研究
Shuxu Wei,Zhouwu Shu,Xinyi Li et al.
Shuxu Wei et al.
Background: Ambient air pollution aggravates cardiovascular-kidney-metabolic (CKM) disorders and sarcopenia, yet the shared genetic and epigenetic mechanisms that underlie their frequent co-occurrence remain poorly unders...
DC-SIGN+ macrophages alleviate metabolic dysfunction-associated steatotic liver disease via fine-tuning TLR4 signaling and inflammatory secretory profiles [0.03%]
DC-SIGN+巨噬细胞通过微调TLR4信号传导和炎性分泌谱型来缓解与代谢紊乱相关的肝脂肪变性疾病
Jinxia Liu,Haifeng Wu,Ling Zhou et al.
Jinxia Liu et al.
Background & aims: Innate immune receptors play a pivotal role in modulating immune responses during the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aims to comprehensively ...
Induction of yin Yang 1 (YY1) overexpression in mature adipocytes promotes dysfunctional adipose tissue and systemic insulin resistance in mice [0.03%]
在成熟脂肪细胞中诱导YIN阳1过表达可促进小鼠出现功能障碍型脂肪组织和全身性胰岛素抵抗
Line Pedersen,Christy M Gliniak,Thomas Myhre Dale et al.
Line Pedersen et al.
The ubiquitous transcription factor Ying Yang 1 (YY1) plays a fundamental role in multiple biological processes and is believed to regulate up to 10 % of all human genes. In thermogenic brown adipose tissue, YY1 has been linked to controlli...
Corrigendum to "Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model" [Metab Clin Exp 119 (2021) 154749 1-14 [METABOLISM-D-20-01502R3]] [0.03%]
关于“11β-羟基类固醇脱氢酶Ⅰ型在多囊卵巢综合征发病机制中的作用及其选择性抑制的潜在治疗效果在临床前模型中”的勘误修正[Metab Clin Exp 119 (2021) 154749 1-14 [METABOLISM-D-20-01502R3]]
Xinyu Li,Shuanggang Hu,Qinling Zhu et al.
Xinyu Li et al.
Obesity rewires CD8+ T cell iron metabolism in adipose tissue to fuel metabolic inflammation [0.03%]
肥胖重塑驻留于脂肪组织中CD8+t细胞的铁代谢为代谢性炎症供能
Jinfen Dai,Zixuan Zeng,Lishuan Wang et al.
Jinfen Dai et al.
Sufficient nutrient supply is important for the maintenance of non-lymphoid tissue resident CD8+ T cell homeostasis, but the role of labile iron remains unclear. Here, we find adipose tissue CD8+ T cells exhibit elevated labile iron and mit...
HDL dysfunction: a role in the pathogenesis of cardiometabolic syndrome in chronic HIV infection? [0.03%]
HIV慢性感染中心肌代谢综合征的发病机制:HDL功能障碍的作用？
Konstantinos Markakis,Leila Fotooh Abadi,Arnaud Kombe Kombe et al.
Konstantinos Markakis et al.
People living with human immunodeficiency virus (HIV) (PLWH) on antiretroviral treatment (ART) have an increased risk of atherosclerotic cardiovascular disease (CVD) and metabolic syndrome (combinations of adiposity, insulin resistance, hyp...