Effect of alternate-day fasting on obesity and cardiometabolic risk: A systematic review and meta-analysis [0.03%]
间隔日禁食对肥胖和心血管代谢风险的影响：系统回顾与荟萃分析
Jihyun Park,Young-Gyun Seo,Yu-Jin Paek et al.
Jihyun Park et al.
Background & aims: Alternate-day fasting (ADF) is related to weight reduction, lowered risks of weight regain, and relative lean body mass preservation compared to continuous energy restriction. This meta-analysis aimed t...
Generation and characterisation of C-terminally stabilised PYY molecules with potential in vivo NPYR2 activity [0.03%]
具有潜在体内NPYR2活性的C-末端稳定PYY分子的生成和特征化
Ryan A Lafferty,Neil Tanday,Peter R Flatt et al.
Ryan A Lafferty et al.
Background: Activation of neuropeptide Y2 receptors (NPYR2) by the N-terminally truncated, dipeptidyl peptidase-4 (DPP-4) generated, Peptide YY (PYY) metabolite, namely PYY(3-36), results in satiating actions. However, PY...
Making progress towards a better pathophysiological understanding and more promising therapeutic options for treating non-alcoholic steatohepatitis (NASH)/DASH (dysmetabolism associated steatohepatitis) [0.03%]
走向更好的病生理学理解以及更有效的治疗非酒精性脂肪肝炎（NASH）/代谢紊乱相关性脂肪肝炎症(DASH)的治疗方法进程中
Niki Katsiki,Christos Mantzoros
Niki Katsiki
Elevated FURIN levels in predicting mortality and cardiovascular events in patients with acute myocardial infarction [0.03%]
FURIN水平升高预测急性心肌梗死患者死亡和心血管事件发生情况
Yun Kai Wang,Jia Ni Tang,Lu Han et al.
Yun Kai Wang et al.
Objectives: Proprotein convertase subtilisin/kexin (PCSK) family member 3 (FURIN) has been suggested to be involved in the development of atherosclerosis. The aim of this study was to investigate the prognostic implicatio...
Commentary. Eliminating vitamin D deficiency during the COVID-19 pandemic: A call to action [0.03%]
述评。在新型冠状病毒肺炎大流行期间消除维生素D缺乏：行动呼吁
JoAnn E Manson,Shari S Bassuk
JoAnn E Manson
Visceral fat shows the strongest association with the need of intensive care in patients with COVID-19 [0.03%]
腹腔内脂肪是新冠肺炎患者是否需要重症监护最强的预测指标
Mikiko Watanabe,Damiano Caruso,Dario Tuccinardi et al.
Mikiko Watanabe et al.
Background: Obesity was recently identified as a major risk factor for worse COVID-19 severity, especially among the young. The reason why its impact seems to be less pronounced in the elderly may be due to the concomitan...
The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease [0.03%]
组学在非酒精性脂肪性肝病病理生理、诊断和治疗中的作用
Nikolaos Perakakis,Konstantinos Stefanakis,Christos S Mantzoros
Nikolaos Perakakis
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose spectrum covers clinical, histological and pathophysiological developments ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and liver...
Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice [0.03%]
达格列净通过诱导2型糖尿病小鼠胰腺内分泌细胞转分化促进β细胞再生
Rui Wei,Xiaona Cui,Jin Feng et al.
Rui Wei et al.
Background: Clinical trials and animal studies have shown that sodium-glucose co-transporter type 2 (SGLT2) inhibitors improve pancreatic beta cell function. Our study aimed to investigate the effect of dapagliflozin on i...
Muscle area and density and risk of all-cause mortality: The Multi-Ethnic Study of Atherosclerosis [0.03%]
骨骼肌面积和密度与全因死亡率的关系：动脉粥样硬化的多种族研究调查结果
Britta Larsen,John Bellettiere,Matthew Allison et al.
Britta Larsen et al.
Background: Lean muscle plays critical roles in physical functioning and metabolism. However, little is known regarding associations between muscle and mortality in adults. ...
Making progress in nonalcoholic fatty liver disease (NAFLD) as we are transitioning from the era of NAFLD to dys-metabolism associated fatty liver disease (DAFLD) [0.03%]
从非酒精性脂肪肝病(NAFLD)时代过渡到代谢失调相关性脂肪肝病(DAFLD)时代的DAFLD进展研究
Stergios A Polyzos,Christos S Mantzoros
Stergios A Polyzos
•This is a special issue of “Metabolism” dedicated to nonalcoholic fatty liver disease.•Experts in the field provide an overview of recent progress and developments in NAFLD and offer their expert opinion on future directions.•NAFLD re...