Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data [0.03%]
肥胖及其遗传易感性与严重COVID-19风险的相关性：基于人群队列数据分析
Zhaozhong Zhu,Kohei Hasegawa,Baoshan Ma et al.
Zhaozhong Zhu et al.
Objective: We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data. ...
Diabetes, glycaemic control, and risk of COVID-19 hospitalisation: Population-based, prospective cohort study [0.03%]
糖尿病、血糖控制与COVID-19住院风险：基于人群的前瞻性队列研究
Mark Hamer,Catharine R Gale,G David Batty
Mark Hamer
Objective: We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study. ...
Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease [0.03%]
过氧化物酶增殖物激活受体β/δ在非酒精性脂肪肝病中作用的揭示
Mohammad Zarei,David Aguilar-Recarte,Xavier Palomer et al.
Mohammad Zarei et al.
Nonalcoholic fatty liver disease (NAFLD), a form of chronic liver disease that occurs in individuals with no significant alcohol abuse, has become an increasing concern for global health. NAFLD is defined as the presence of lipid deposits i...
Absence of AGPAT2 impairs brown adipogenesis, increases IFN stimulated gene expression and alters mitochondrial morphology [0.03%]
AGPAT2的缺失会损害棕色脂肪细胞的生成，增加干扰素刺激基因表达并改变线粒体形态结构
Pablo J Tapia,Ana-María Figueroa,Verónica Eisner et al.
Pablo J Tapia et al.
Background: Biallelic loss of function variants in AGPAT2, encoding 1-acylglycerol-3-phosphate O-acyltransferase 2, cause congenital generalized lipodystrophy type 1, a disease characterized by near total loss of white ad...
Cardiovascular outcomes trials with incretin-based medications: a critical review of data available on GLP-1 receptor agonists and DPP-4 inhibitors [0.03%]
基于增血糖素类似药物的心血管结局试验：GLP-1受体激动剂和DPP-4抑制剂的数据批判性回顾
Alexandros Sachinidis,Dragana Nikolic,Anca Pantea Stoian et al.
Alexandros Sachinidis et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors are so called "incretin-based therapies" (IBTs) that represent innovative therapeutic approaches and are commonly used in clinical practice f...
Atish Mukherji,Mayssa Dachraoui,Thomas F Baumert
Atish Mukherji
All living organisms including humans, experience changes in the light exposure generated by the Earth's rotation. In anticipation of this unavoidable geo-physical variability, and to generate an appropriate biochemical response, species of...
Inhibition of miR-153, an IL-1β-responsive miRNA, prevents beta cell failure and inflammation-associated diabetes [0.03%]
抑制IL-1β反应性miRNA的miR-153可防止β细胞功能衰竭及炎症糖尿病
Yi Sun,Shixiang Zhou,Ying Shi et al.
Yi Sun et al.
Objective: Systemic levels of up-regulated IL-1β and IL-1 receptors promote the pathogenesis of inflammation-associated diabetes. IL-1 receptor antagonist (IL-Ra) has shown slightly elevated beta cell function in patient...
The role of peroxisome proliferator-activated receptors (PPAR) in immune responses [0.03%]
过氧化物酶体增殖激活受体(PPAR)在免疫反应中的作用
Anthos Christofides,Eirini Konstantinidou,Chinmay Jani et al.
Anthos Christofides et al.
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ,...
Disrupted endothelial cell heterogeneity and network organization impair vascular function in prediabetic obesity [0.03%]
糖尿病肥胖症中破坏的内皮细胞异质性和网络组织妨碍血管功能
Calum Wilson,Xun Zhang,Matthew D Lee et al.
Calum Wilson et al.
Background: Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest stages of obesity and underlies vas...
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway [0.03%]
恩格列净通过AMPK/SP1/PGAM5通路减轻线粒体裂变从而改善糖尿病肾小管损伤
Xiangyang Liu,Chaofei Xu,Linxin Xu et al.
Xiangyang Liu et al.
Background and purpose: Excessive mitochondrial fission was observed in diabetic kidney disease (DKD). Phosphoglycerate mutase family member 5 (PGAM5) plays an important role in mitochondrial fission by dephosphorylating ...