Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice [0.03%]
肝胰岛素酶调节饮食诱导肥胖小鼠的血糖和胰岛素稳态
Beatriz Merino,Cristina M Fernández-Díaz,Cristina Parrado-Fernández et al.
Beatriz Merino et al.
The insulin-degrading enzyme (IDE) is a metalloendopeptidase with a high affinity for insulin. Human genetic polymorphisms in Ide have been linked to increased risk for T2DM. In mice, hepatic Ide ablation causes glucose intolerance and insu...
YY1 deficiency in β-cells leads to mitochondrial dysfunction and diabetes in mice [0.03%]
β细胞中YY1缺乏导致小鼠线粒体功能障碍和糖尿病
Dalong Song,Qi Yang,Xiuli Jiang et al.
Dalong Song et al.
Background: The transcription factor YY1 is an important regulator for metabolic homeostasis. Activating mutations in YY1 lead to tumorigenesis of pancreatic β-cells, however, the physiological functions of YY1 in β-cel...
Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults [0.03%]
果糖和葡萄糖对年轻成年人的心血管疾病脂蛋白危险因素的协同作用
Bettina Hieronimus,Valentina Medici,Andrew A Bremer et al.
Bettina Hieronimus et al.
Background: Fructose consumption increases risk factors for cardiometabolic disease. It is assumed that the effects of free sugars on risk factors are less potent because they contain less fructose. We compared the effect...
Urinary GC-MS steroid metabotyping in treated children with congenital adrenal hyperplasia [0.03%]
尿液GC-MS类固醇代谢分型在治疗先天性肾上腺皮质增生症儿童中的应用
Clemens Kamrath,Michaela F Hartmann,Jörn Pons-Kühnemann et al.
Clemens Kamrath et al.
Background: Treatment of children with classic congenital adrenal hyperplasia (CAH) is a difficult balance between hypercortisolism and hyperandrogenism. Biochemical monitoring of treatment is not well defined. ...
Interesterified palm oil impairs glucose homeostasis and induces deleterious effects in liver of Swiss mice [0.03%]
兴趣酯化棕榈油破坏瑞士鼠标本的血糖稳态并在肝内产生不良影响
Josiane Érica Miyamoto,Andressa Reginato,Mariana Portovedo et al.
Josiane Érica Miyamoto et al.
Background: Interesterified fats have largely replaced the partially hydrogenated oils which are the main dietary source of trans fat in industrialized food. This process promotes a random rearrangement of the native fatt...
High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study [0.03%]
冠状动脉疾病与高密度脂蛋白特性：一项孟德尔随机研究
Albert Prats-Uribe,Sergi Sayols-Baixeras,Alba Fernández-Sanlés et al.
Albert Prats-Uribe et al.
Background: To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). ...
Association of class number, cumulative exposure, and earlier initiation of antibiotics during the first two-years of life with subsequent childhood obesity [0.03%]
生命中头两年分类数量、累积暴露量以及较早开始接触抗生素与随后的儿童期肥胖之间的联系
Young Jun Park,Jooyoung Chang,Gyeongsil Lee et al.
Young Jun Park et al.
Background: Despite the possible association between antibiotic overuse and childhood obesity, studies on this association are lacking in Asia. This study aimed to determine whether there is an association between the num...
Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice [0.03%]
Hrd1介导的ACLY泛素化减轻db/db小鼠中的NAFLD
Kai Li,Kaini Zhang,Hai Wang et al.
Kai Li et al.
Background: The functions of Acly in regulating nonalcoholic fatty liver disease (NAFLD) have been identified; however, the dynamic control of Acly expression under the pathological state of metabolic disorders has not be...
Effect of long-term testosterone therapy on molecular regulators of skeletal muscle mass and fibre-type distribution in aging men with subnormal testosterone [0.03%]
长期睾酮疗法对睾酮水平低的年长男性骨骼肌质量和纤维类型分布的分子调节器的影响
Rikke Kruse,Stine J Petersson,Louise L Christensen et al.
Rikke Kruse et al.
Background: Long-term testosterone replacement therapy (TRT) increases muscle mass in elderly men with subnormal testosterone levels. However, the molecular mechanisms underlying this effect of TRT on protein balance in h...
β-cell impairment and clinically meaningful alterations in glycemia in obese youth across the glucose tolerance spectrum [0.03%]
肥胖青年在葡萄糖耐量全谱中的β细胞损伤和临床上有意义的血糖改变
Joon Young Kim,Hala Tfayli,Fida Bacha et al.
Joon Young Kim et al.
Background/aims: In obese youth, it is not clear what degree of β-cell impairment translates to glucose dysregulation commensurate with shifts from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to ty...