Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice [0.03%]
高血糖减少糖尿病小鼠眼中NAD+生物合成从而影响角膜上皮伤口愈合
Ya Li,Jing Li,Can Zhao et al.
Ya Li et al.
Objective: Nicotinamide adenine dinucleotide (NAD) is an essential molecule participating in multiple physiological and pathophysiological processes. In diabetic cornea, the NAD+-consuming enzyme SIRT1 was down-regulated ...
Circulating profile of Activin-Follistatin-Inhibin Axis in women with hypothalamic amenorrhea in response to leptin treatment [0.03%]
低泌乳素治疗对下丘脑闭经女性激活素-卵泡刺激素抑制轴循环状态的影响
Eirini Bouzoni,Nikolaos Perakakis,Christos S Mantzoros
Eirini Bouzoni
Background: Chronic energy deficiency observed in women that exercise strenuously affects reproductive function, often leading to hypothalamic amenorrhea (HA). In such conditions, hypoleptinemia and robust changes in the ...
KCa channel activation normalizes endothelial function in Type 2 Diabetic resistance arteries by improving intracellular Ca2+ mobilization [0.03%]
KCa通道激活通过改善细胞内钙动员来改善二型糖尿病阻力动脉的内皮功能
Ramesh C Mishra,Barry D Kyle,Dylan J Kendrick et al.
Ramesh C Mishra et al.
Background: Endothelial dysfunction is an early pathogenic event in the progression of cardiovascular disease in patients with Type 2 Diabetes (T2D). Endothelial KCa2.3 and KCa3.1 K+ channels are important regulators of a...
Robert Dent,Ruth McPherson,Mary-Ellen Harper
Robert Dent
Current obesity treatment strategies include diet, exercise, bariatric surgery, and a limited but growing repertoire of medications. Individual weight loss in response to each of these strategies is highly variable. Here we review research ...
Obesity in patients with COVID-19: a systematic review and meta-analysis [0.03%]
COVID-19患者中的肥胖问题：系统回顾和荟萃分析
Yi Huang,Yao Lu,Yan-Mei Huang et al.
Yi Huang et al.
Background: Obesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes of COVID-19 warrant systematical investigation. ...
Commentary: Statins, COVID-19, and coronary artery disease: killing two birds with one stone [0.03%]
评论：他汀类药物，COVID-19和冠状动脉疾病：一石二鸟
Shiva Ganjali,Vanessa Bianconi,Peter E Penson et al.
Shiva Ganjali et al.
Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity [0.03%]
促纤维化的M2型巨噬细胞的标志物可能会增加肥胖的二型糖尿病患者感染COVID19的风险
Abu Saleh Md Moin,Thozhukat Sathyapalan,Stephen L Atkin et al.
Abu Saleh Md Moin et al.
Association of body mass index (BMI) with critical COVID-19 and in-hospital mortality: A dose-response meta-analysis [0.03%]
体重指数(BMI)与重症新冠肺炎及住院死亡率的关联性：一项剂量反应荟萃分析
Yanbin Du,Yuan Lv,Wenting Zha et al.
Yanbin Du et al.
Background and purpose: The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented health crisis to the entire world. As reported, the body mass index (BMI) may play an important role in COVID-19; however,...
Zihang Wang,Xiaofang Zhang,Xiaodan Lu
Zihang Wang
Use of imaging techniques for non-invasive assessment in the diagnosis and staging of non-alcoholic fatty liver disease [0.03%]
影像技术在非酒精性脂肪肝病诊断和分期中的应用评估
Luca Miele,Maria A Zocco,Fabrizio Pizzolante et al.
Luca Miele et al.
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and represent a common finding in highly prevalent metabolic disorders (i.e. type 2 diabetes, metabolic syndrome, obesity). Non-alcoholic steatohepatitis (...