Metabolic impact of weight loss induced reduction of adipose ACE-2 - Potential implication in COVID-19 infections? [0.03%]
减肥引起的脂肪组织ACE-2减少对代谢的影响——对COVID-19感染的潜在影响？
Linna Li,Leonard Spranger,Dominik Soll et al.
Linna Li et al.
Background & aims: Angiotensin converting enzyme (ACE)-2 is a modulator of adipose tissue metabolism. However, human data of adipose ACE-2 is rarely available. Considering that, ACE-2 is believed to be the receptor respon...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2020 Dec:113:154401. DOI:10.1016/j.metabol.2020.154401 2020
Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved [0.03%]
视黄醇稳态紊乱通过O-连接的N-乙酰葡萄糖胺修饰引起糖尿病中RBP4过表达
Shyi-Jang Shin,Chao-Hung Chen,Wen-Chen Kuo et al.
Shyi-Jang Shin et al.
Background: Retinol-binding protein 4 (RBP4) is elevated and associated with inflammation in metabolic diseases. Disruption of the retinol cascade and O-GlcNAcylation of the RBP4 receptor (STRA6) are found in diabetic kid...
UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice [0.03%]
急性冷暴露诱导小鼠棕色脂肪组织中UCP1依赖和非依赖性代谢变化
Yuko Okamatsu-Ogura,Masashi Kuroda,Rie Tsutsumi et al.
Yuko Okamatsu-Ogura et al.
Background: Brown adipose tissue (BAT) is a site of metabolic thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1) and represents a target for a therapeutic intervention in obesity. Cold exposure activates ...
Weight gain during early adulthood, trajectory of body shape and the risk of nonalcoholic fatty liver disease: A prospective cohort study among women [0.03%]
成年早期的体重增加，体型变化轨迹与非酒精性脂肪肝的风险之间的关系：一项女性队列研究
Mi Na Kim,Chun-Han Lo,Kathleen E Corey et al.
Mi Na Kim et al.
Background & aims: Obesity is established as a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). However, the influence of dynamic changes in adiposity over the life course on NAFLD risk r...
Enhanced cardiac hypoxic injury in atherogenic dyslipidaemia results from alterations in the energy metabolism pattern [0.03%]
动脉粥样硬化性血脂异常导致心脏缺氧损伤加重是由能量代谢模式改变引起的
Mariola Olkowicz,Marta Tomczyk,Janusz Debski et al.
Mariola Olkowicz et al.
Objective: Dyslipidaemia is a major risk factor for myocardial infarction that is known to correlate with atherosclerosis in the coronary arteries. We sought to clarify whether metabolic alterations induced by dyslipidaem...
The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes [0.03%]
CCL25-CCR9轴在β细胞功能中的作用：在2型糖尿病治疗中的潜在干预可能性
Patricio Atanes,Vivian Lee,Guo Cai Huang et al.
Patricio Atanes et al.
Background and purpose: Chemokines are known to play essential roles mediating immunity and inflammation in many physiological and pathophysiological processes, with reports linking their action to the development of obes...
Adiponectin's mechanisms in high-density lipoprotein biogenesis and cholesterol efflux [0.03%]
脂联素在高密度脂蛋白生物发生和胆固醇流出中的机制作用
Anouar Hafiane,Stella S Daskalopoulou
Anouar Hafiane
Aim: Among adiponectin's beneficial properties is its ability to promote cellular cholesterol efflux, thereby generating high-density lipoprotein (HDL) particles. However, adiponectin's role in the regulation of macrophag...
Laura D&#x;Erasmo,Alessia Di Costanzo,Antonio Gallo et al.
Laura D&#x;Erasmo et al.
ApoCIII has a well-recognized role in triglyceride-rich lipoproteins metabolism. A considerable amount of data has clearly highlighted that high levels of ApoCIII lead to hypertriglyceridemia and, thereby, may influence the risk of cardiova...
Beclin1 haploinsufficiency rescues low ambient temperature-induced cardiac remodeling and contractile dysfunction through inhibition of ferroptosis and mitochondrial injury [0.03%]
Beclin1单倍不足通过抑制铁死亡和线粒体损伤来挽救低温诱导的心肌重塑和收缩功能障碍
Zhiqiang Yin,Gangbing Ding,Xu Chen et al.
Zhiqiang Yin et al.
Objective: Cold exposure provokes cardiac remodeling and cardiac dysfunction. Autophagy participates in cold stress-induced cardiovascular dysfunction. This study was designed to examine the impact of Beclin1 haploinsuffi...
Testosterone, dihydrotestosterone, bone density, and hip fracture risk among older men: The Cardiovascular Health Study [0.03%]
睾酮，二氢睾酮，骨密度和老年人髋部骨折的风险：心血管健康研究中的发现
Emily A Rosenberg,Petra Bůžková,Howard A Fink et al.
Emily A Rosenberg et al.
Background: Little is known about the relationships of dihydrotestosterone (DHT), a more potent androgen than testosterone (T), with bone mineral density (BMD) and fracture risk. Our objectives were to evaluate the relati...