Do biomarkers of COVID-19 severity simply reflect a stress response in type 2 diabetes: Biomarker response to hypoglycemia [0.03%]
新冠肺炎严重程度的生物标志物是否仅仅是2型糖尿病应激反应的体现：低血糖的生物标志物反应
Abu Saleh Md Moin,Ahmed Al-Qaissi,Thozhukat Sathyapalan et al.
Abu Saleh Md Moin et al.
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes [0.03%]
不同作用机制导致胰高血糖素样肽-1和胃抑制多肽在2型糖尿病中疗效不同
Eleonora Grespan,Toni Giorgino,Andrea Natali et al.
Eleonora Grespan et al.
Background and aims: The reduced action of incretin hormones in type 2 diabetes (T2D) is mainly attributed to GIP insensitivity, but efficacy estimates of GIP and GLP-1 differ among studies, and the negligible effects of ...
Pioglitazone corrects dysregulation of skeletal muscle mitochondrial proteins involved in ATP synthesis in type 2 diabetes [0.03%]
吡格列酮校正2型糖尿病骨骼肌线粒体参与ATP合成的蛋白表达异常
Teresa Vanessa Fiorentino,Adriana Monroy,Subash Kamath et al.
Teresa Vanessa Fiorentino et al.
Context: In this study, we aimed to identify the determinants of mitochondrial dysfunction in skeletal muscle (SKLM) of subjects with type 2 diabetes (T2DM), and to evaluate the effect of pioglitazone (PIO) on SKLM mitoch...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2021 Jan:114:154416. DOI:10.1016/j.metabol.2020.154416 2021
Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans [0.03%]
去甲肾上腺素纤维与人类β细胞脱分化及β细胞功能障碍相关性研究
F Cinti,T Mezza,I Severi et al.
F Cinti et al.
Aims/hypothesis: Type 2 diabetes (T2D) is characterized by a progressive loss of beta-cell function, and the "disappearance" of beta-cells in T2D may also be caused by the process of beta -cell dedifferentiation. Since no...
Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability [0.03%]
REV-ERBα的药理激活通过调节肠道通透性改善非酒精性脂肪性肝炎
Yinhua Ni,Yufeng Zhao,Lingyan Ma et al.
Yinhua Ni et al.
Background and objectives: The gut-liver axis plays an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH), and increased intestinal permeability causes transfer of endotoxin to the liver, which acti...
Angeliki M Angelidi,Alexander Kokkinos,Eleftheria Katechaki et al.
Angeliki M Angelidi et al.
Commentary: COVID-19 and obesity pandemics converge into a syndemic requiring urgent and multidisciplinary action [0.03%]
评论：COVID-19大流行和肥胖流行病演变成需要紧急多学科行动的同种病态现象
Michael A Hill,James R Sowers,Christos S Mantzoros
Michael A Hill
While substantial evidence points towards obesity and associated cardiometabolic disorders being a major factor for poor outcomes in SARS-CoV2 infections (COVID-19), the complexity of the interplay between these two pandemics is becoming ap...
Histone methyltransferases G9a mediated lipid-induced M1 macrophage polarization through negatively regulating CD36 [0.03%]
组蛋白甲基转移酶G9a通过负调控CD36介导脂质诱导的M1型巨噬细胞极化
Xiuling Wang,Shanshan Chen,Jinrong He et al.
Xiuling Wang et al.
Background: Recent studies have considered the obesity-related lipid environment as the potential cause for M1 macrophage polarization in type 2 diabetes. However, the specific regulatory mechanism is still unclear. Here,...
Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy [0.03%]
钠-葡萄糖协同转运蛋白2抑制通过抑制巨噬素O-连接的N-乙酰葡糖胺化作用减轻进行性糖尿病肾病近曲小管中的蛋白质超载
Hitomi Otomo,Mitsuhiko Nara,Shunsuke Kato et al.
Hitomi Otomo et al.
Aims: The crosstalk between sodium-glucose cotransporter 2 (SGLT2) inhibition and a membrane-associated endocytic receptor megalin function involved in renal proximal tubular protein overload in progressive diabetic nephr...
Fasting status and metabolic health in relation to plasma branched chain amino acid concentrations in women [0.03%]
禁食状态、代谢健康与女性血浆支链氨基酸浓度的关系
Deirdre K Tobias,Samia Mora,Subodh Verma et al.
Deirdre K Tobias et al.
Background: Circulating branched chain amino acids (BCAA) are associated with cardiometabolic risk, although the mechanisms leading to their accumulation remain uncertain. Examining the relationship between fasting status...