Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence [0.03%]
读者来信：维生素D缺乏和新冠肺炎：因果倒置
Joost Smolders,Jody van den Ouweland,Christopher Geven et al.
Joost Smolders et al.
Dan-Qin Sun,Yan Jin,Ting-Yao Wang et al.
Dan-Qin Sun et al.
Background/aims: Whereas nonalcoholic fatty liver disease (NAFLD) is a multisystem disease, the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and extra-hepatic diseases is not known. The...
The chronic effect of cortisol on orchestrating cerebral blood flow and brain functional connectivity: evidence from Cushing's disease [0.03%]
皮质醇对脑血流和脑功能连接的慢性影响：库欣病患者的证据
Yanyang Zhang,Tao Zhou,Shiyu Feng et al.
Yanyang Zhang et al.
Background: Cortisol has long been considered to play a crucial role in the pathogenesis of stress-related disorders. Cushing's disease (CD) provides an excellent "hyperexpression model" to investigate the chronic effects...
Type VI collagen and its cleavage product, endotrophin, cooperatively regulate the adipogenic and lipolytic capacity of adipocytes [0.03%]
VI型胶原及其裂解产物内源性增生素协同调节脂肪细胞的成脂分化及脂解能力
Jiyoung Oh,Chu-Sook Kim,Min Kim et al.
Jiyoung Oh et al.
Objective: Obesity-induced adipose tissue remodeling is closely associated with systemic insulin resistance. However, the mechanistic involvement of adipocyte-derived extracellular matrix proteins under pathophysiological...
A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis [0.03%]
PAK1通过电子传递链蛋白支持线粒体功能和维持细胞氧化还原平衡以防止β细胞凋亡的必要性
Miwon Ahn,Eunjin Oh,Erika M McCown et al.
Miwon Ahn et al.
Objective: p21 (Cdc42/Rac1) activated Kinase 1 (PAK1) is a candidate susceptibility factor for type 2 diabetes (T2D). PAK1 is depleted in the islets from T2D donors, compared to control individuals. In addition, whole-bod...
Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity [0.03%]
新型载脂蛋白A-I胺末端片段通过促进脂解和褐色脂肪组织活性来抑制肥胖的作用机制研究
Helena F Raposo,Patricia Forsythe,Bruno Chausse et al.
Helena F Raposo et al.
Objective: The systemic function of CETP has been well characterized. CETP plasma activity reduces HDL cholesterol and thus increases the risk of atherosclerosis. Here, we investigated whether CETP expression modulate adi...
Commentary: Nonalcoholic or metabolic dysfunction-associated fatty liver disease? The epidemic of the 21st century in search of the most appropriate name [0.03%]
述评：非酒精性或代谢功能异常相关性脂肪肝病？二十一世纪的流行病在寻找一个更合适的名称
Stergios A Polyzos,Eun Seok Kang,Emmanuel A Tsochatzis et al.
Stergios A Polyzos et al.
Dongxu Qiu,David Nikita,Lei Zhang et al.
Dongxu Qiu et al.
Background: The delayed repair process in the aging diabetic population is becoming an alarming public health concern. ICAM-1 plays an important role in orchestrating the repair process by mediating neutrophil recruitment...
Effect of 2-deoxyglucose-mediated inhibition of glycolysis on the regulation of mTOR signaling and protein synthesis before and after high-intensity muscle contraction [0.03%]
2-脱氧葡萄糖介导的糖酵解抑制对高强度肌肉收缩前后的mTOR信号传导和蛋白质合成调节的影响
Takeshi Suginohara,Koki Wakabayashi,Satoru Ato et al.
Takeshi Suginohara et al.
Background: Glycolysis controls mTORC1 signaling and protein synthesis. In skeletal muscle, glucose metabolism increases with both exercise/contraction intensity and volume, and therefore, high-intensity muscle contractio...
Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score [0.03%]
DLL1与低多基因风险评分1型糖尿病患者表型的关联研究
Jingchun Qu,Hui-Qi Qu,Jonathan P Bradfield et al.
Jingchun Qu et al.
Type 1 diabetes (T1D) is a heterogeneous disease. This study identified T1D cases with low polygenic risk score (PRS) to better represent T1D cases with less prominent autoimmune response (T1bD), and performed a gene-based association study...