Mean and visit-to-visit variability of glycemia and left ventricular diastolic dysfunction: A longitudinal analysis of 3025 adults with serial echocardiography [0.03%]
糖化血红蛋白平均水平及逐访波动与舒张性心力衰竭的关系：基于3025名受试者超声心动图的纵向数据分析
Jiyeon Ahn,Janghyun Koh,Darae Kim et al.
Jiyeon Ahn et al.
Objective: We aimed to determine the mean glucose thresholds to increase the risk of left ventricular diastolic dysfunction (LVDD) and whether visit-to-visit variability of fasting plasma glucose (FPG) and glycated hemogl...
Yanjun Guo,Qinqiu Wang,Shenghui Chen et al.
Yanjun Guo et al.
Amyloid precursor protein (APP) is a transmembrane precursor protein that is widely expressed in the central nervous system and peripheral tissues in the liver and pancreas, adipose tissue, and myotubes. APP can be cleaved by proteases in t...
Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester [0.03%]
心力衰竭患者的心肌酮体利用：口服酮酯的影响
Luca Monzo,Kamil Sedlacek,Katarina Hromanikova et al.
Luca Monzo et al.
Aims: Upregulation of ketone body (β-hydroxybutyrate, βHB) utilization has been documented in human end-stage heart failure (HF), but is unclear if this is due to intrinsic cardiac metabolic remodeling or a HF-related c...
Marie-Eve Piché,Isabelle Tardif,Audrey Auclair et al.
Marie-Eve Piché et al.
Most patients with severe obesity will present some lipid-lipoprotein abnormalities. The atherogenic dyslipidemia associated with severe obesity is characterized by elevated fasting and postprandial triglyceride levels, low high-density lip...
Guillaume Favre,Kevin Legueult,Christian Pradier et al.
Guillaume Favre et al.
Background: Excess visceral fat (VF) or high body mass index (BMI) is risk factors for severe COVID-19. The receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is expressed at higher levels in the VF...
Moderate alcohol consumption is associated with advanced fibrosis in non-alcoholic fatty liver disease and shows a synergistic effect with type 2 diabetes mellitus [0.03%]
中度饮酒与非酒精性脂肪肝病的纤维化呈正相关，并且与2型糖尿病具有协同效应
Julia Blomdahl,Patrik Nasr,Mattias Ekstedt et al.
Julia Blomdahl et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Whether moderate alcohol consumption plays a role for progression of NAFLD is disputed. Moreover, it is not known w...
Epicardial adipose tissue is associated with extent of pneumonia and adverse outcomes in patients with COVID-19 [0.03%]
心外膜脂肪组织与COVID-19患者的肺炎范围和不良结局有关
Kajetan Grodecki,Andrew Lin,Aryabod Razipour et al.
Kajetan Grodecki et al.
Aim: We sought to examine the association of epicardial adipose tissue (EAT) quantified on chest computed tomography (CT) with the extent of pneumonia and adverse outcomes in patients with coronavirus disease 2019 (COVID-...
Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity [0.03%]
识别出一种新的瘦素受体(LEPR)变异并证明其功能相关性以指导病态肥胖患者的治疗决策
Franziska Voigtmann,Philipp Wolf,Kathrin Landgraf et al.
Franziska Voigtmann et al.
Background: Deficiency in the leptin-leptin receptor (LEPR) axis leads to severe, and potentially treatable, obesity in humans. To guide clinical decision-making, the functional relevance of variants in the LEPR gene need...
Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury [0.03%]
成纤维细胞生长因子-23和α-Klotho在急性肾损伤中的作用
Pan-Pan Hu,Jing-Fu Bao,Aiqing Li
Pan-Pan Hu
Acute kidney injury is a global disease with high morbidity and mortality. Recent studies have revealed that the fibroblast growth factor-23-α-Klotho axis is closely related to chronic kidney disease, and has multiple biological functions ...
Letter to the Editor: Obesity, diabetes, non-alcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease are proinflammatory hypercoagulable states associated with severe disease and thrombosis in Covid-19 [0.03%]
读者来信：肥胖、糖尿病、非酒精性脂肪肝病和代谢功能紊乱相关脂肪肝病与Covid-19的严重疾病和血栓形成有关
Dong Ji,Mingjie Zhang,Enqiang Qin et al.
Dong Ji et al.