Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse [0.03%]
抑制糖酵解可缓解智力障碍小鼠GDI1基因缺失导致的学习记忆障碍
Patrizia D&#x;Adamo,Anemari Horvat,Antonia Gurgone et al.
Patrizia D&#x;Adamo et al.
Objectives: GDI1 gene encodes for αGDI, a protein controlling the cycling of small GTPases, reputed to orchestrate vesicle trafficking. Mutations in human GDI1 are responsible for intellectual disability (ID). In mice wi...
Reply to Vitamin D deficiency in COVID-19: mixing up cause and consequence [0.03%]
维生素D缺乏与COVID-19：因果倒置
M Chakhtoura,G El Hajj Fuleihan
M Chakhtoura
Eftaxia-Konstantina Valanti,Katerina Dalakoura-Karagkouni,Gerasimos Siasos et al.
Eftaxia-Konstantina Valanti et al.
Atherosclerosis is a multifactorial disease influenced by genetics, lifestyle and environmental factors. Despite therapeutic advances that reduce the risk of cardiovascular events, atherosclerosis-related diseases remain the leading cause o...
AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction [0.03%]
能量状态与繁殖之间的AMP活化蛋白激酶（AMPK）信号机制
D Franssen,A Barroso,F Ruiz-Pino et al.
D Franssen et al.
Background: Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, master elements and final output pathway for the brain control of reproduction, directly or indirectly receive and integrate m...
Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis [0.03%]
脯氨酰异构酶Pin1与脂肪甘油三酯脂酶互作并通过抑制其表达及脂肪分解负调控小鼠和人的脂解作用
Yusuke Nakatsu,Takeshi Yamamotoya,Mizuki Okumura et al.
Yusuke Nakatsu et al.
Background: Lipolysis is essential for the supply of nutrients during fasting, the control of body weight, and remodeling of white adipose tissues and thermogenesis. In the obese state, lipolysis activity and the expressi...
Direct impact of gonadotropins on glucose uptake and storage in preovulatory granulosa cells: Implications in the pathogenesis of polycystic ovary syndrome [0.03%]
促性腺激素直接影响排卵前颗粒细胞的葡萄糖摄取和储存：对多囊卵巢综合征发病机制的意义
Nidhi Chahal,Anjali Geethadevi,Surleen Kaur et al.
Nidhi Chahal et al.
Background: Polycystic ovary syndrome (PCOS) is often associated with higher levels of LH, and arrested ovarian follicular growth. The direct impact of high LH on FSH mediated metabolic responses in PCOS patients is not c...
Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression [0.03%]
非酒精性脂肪肝病进展的胆酸谱、组织病理学指标和遗传变异
Nisreen Nimer,Ibrahim Choucair,Zeneng Wang et al.
Nisreen Nimer et al.
Objective: Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy controls. However, it remains unclear whether or no...
The effect of the magnitude of weight loss on non-alcoholic fatty liver disease: A systematic review and meta-analysis [0.03%]
体重减轻程度对非酒精性脂肪肝的影响：一项系统回顾和荟萃分析
Dimitrios A Koutoukidis,Constantinos Koshiaris,John A Henry et al.
Dimitrios A Koutoukidis et al.
Background: Trials show that weight loss interventions improve biomarkers of non-alcoholic fatty liver disease (NAFLD), but it is unclear if a dose-response relationship exists. ...
CT-derived abdominal adiposity: Distributions and better predictive ability than BMI in a nationwide study of 59,429 adults in China [0.03%]
基于CT的中国成年人腹部脂肪分布特征及代谢性预测能力：一项包含59429人的全国性调查研究
Qiang Zeng,Ling Wang,Shengyong Dong et al.
Qiang Zeng et al.
Background: Although abdominal adiposity is associated with an altered cardiometabolic risk profile, the specific contribution of abdominal adipose tissue distribution remains not fully understood. Computed tomography (CT...
The nutrient sensing pathways FoxO1/3 and mTOR in the heart are coordinately regulated by central leptin through PPARβ/δ. Implications in cardiac remodeling [0.03%]
心脏中的营养感应途径FoxO1/3和mTOR通过中枢瘦素和PPARβ/δ协调调节及其在心室重构中的作用
Blanca Rubio,Cristina Mora,Cristina Pintado et al.
Blanca Rubio et al.
Background: Cardiovascular disease in obese individuals with type 2 diabetes is often associated with hyperleptinemia and leptin resistance, while other studies support that leptin has cardioprotective effects. Besides, t...