PPARα/RXRα downregulates amino acid catabolism in the liver via interaction with HNF4α promoting its proteasomal degradation [0.03%]
PPARα/RXRα通过与HNF4α互作促进其泛素化降解从而抑制肝脏氨基酸分解代谢
Sandra Tobón-Cornejo,Ariana Vargas-Castillo,Alekxa Leyva-Martínez et al.
Sandra Tobón-Cornejo et al.
The preservation of body proteins is essential to guarantee their functions in organisms. Therefore, the utilization of amino acids as energy substrates is regulated by a precise fine-tuned mechanism. Recent evidence suggests that the trans...
Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring [0.03%]
母体高脂高蔗糖饮食和孕期运动调节母亲及子代雄鼠肝脏脂肪蓄积及线粒体呼吸能力
Jelena Stevanović-Silva,Jorge Beleza,Pedro Coxito et al.
Jelena Stevanović-Silva et al.
Background: Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercis...
Excess body weight is an independent risk factor for severe forms of COVID-19 [0.03%]
体重超重是新冠肺炎重症的独立风险因素
Léa Pietri,Roch Giorgi,Audrey Bégu et al.
Léa Pietri et al.
Background and aims: Few studies distinguished the independent role of overweight/obesity or their associated-comorbidities in the evolution towards severe forms of COVID-19. Obesity as a unifying risk factor for severe C...
Observational Study
Metabolism: clinical and experimental. 2021 Apr:117:154703. DOI:10.1016/j.metabol.2021.154703 2021
Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors [0.03%]
血脂(a)与冠状动脉钙化：前瞻性研究评估与其他风险因素的相互作用
Kwok Leung Ong,Robyn L McClelland,Matthew A Allison et al.
Kwok Leung Ong et al.
Background: Elevated plasma lipoprotein (a) [Lp(a)] and coronary artery calcification (CAC) are established cardiovascular risk factors that correlate with each other. We hypothesized that other cardiovascular risk factor...
Xinzhi Li,Yuze Jiang,Xu Sun et al.
Xinzhi Li et al.
N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored...
Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: The role of hydrogen sulfide [0.03%]
牛磺酸治疗可逆转蛋白质营养不良引起的胰血管内皮功能障碍：硫化氢的作用
Daniele M Guizoni,Israelle N Freitas,Jamaira A Victorio et al.
Daniele M Guizoni et al.
Background: Protein malnutrition in childhood predisposes individuals to vascular and pancreatic endocrine dysfunction, thus increasing the risk of diabetes and hypertension. Because taurine may reduce cardiometabolic ris...
LKB1 up-regulation inhibits hypothalamic inflammation and attenuates diet-induced obesity in mice [0.03%]
LKB1上调抑制下丘脑炎症并减轻小鼠饮食诱导的肥胖症状
Zhaoxia Wu,Pengjiao Xi,Yan Zhang et al.
Zhaoxia Wu et al.
Background: Diet-induced obesity (DIO) is associated with chronic, low-grade inflammation in the hypothalamus. The inflammatory pathway of the hypothalamus is activated during obesity, and inhibition of activation of the ...
Human adipose tissue-derived stem cell paracrine networks vary according metabolic risk and after TNFα-induced death: An analysis at the single-cell level [0.03%]
基于代谢风险和TNFα诱导死亡的人脂肪组织来源干细胞旁分泌网络的单细胞分析不同
Wilfredo Oliva-Olivera,Daniel Castellano-Castillo,Ferdinand von Meyenn et al.
Wilfredo Oliva-Olivera et al.
Objective: Adipose tissue-derived stem cells (ASCs) might play an important role in adipose microenvironment remodelling during tissue expansion through their response to hypoxia. We examined the cytokine profiles of hypo...
Serum uric acid is associated with increased risk of posttransplantation diabetes in kidney transplant recipients: a prospective cohort study [0.03%]
血清尿酸与肾脏移植受者的术后糖尿病风险增加有关：一项前瞻性队列研究
Camilo G Sotomayor,Sara Sokooti Oskooei,Nicolás I Bustos et al.
Camilo G Sotomayor et al.
Background: Serum uric acid (SUA) is associated with fasting glucose in healthy subjects, and prospective epidemological studies have shown that elevated SUA is associated with increased risk of type 2 diabetes. Whether S...
CER-001 ameliorates lipid profile and kidney disease in a mouse model of familial LCAT deficiency [0.03%]
CER-001可改善LCAT缺陷家族小鼠模型中的血脂状况和肾脏疾病
Alice Ossoli,Arianna Strazzella,Daniela Rottoli et al.
Alice Ossoli et al.
Objective: CER-001 is an HDL mimetic that has been tested in different pathological conditions, but never with LCAT deficiency. This study was designed to investigate whether the absence of LCAT affects the catabolic fate...