Metabolomic aging clock predicts risk of different cardiovascular diseases in the UK Biobank [0.03%]
代谢组衰老时钟预测英国生物银行中不同心血管疾病的风险
Guochang You,Kangjie Wang,Runnan Shen et al.
Guochang You et al.
Current metabolomic aging clocks inadequately capture individual heterogeneity in biological aging trajectories, constraining their clinical utility. Here, we developed a metabolomic age clock in the UK Biobank (n = 196,790) using a compreh...
Corrigendum to "Emerging roles of arginine metabolism in skeletal health and disease" [Metabolism 2025 Nov 19:175:156451. / PMID: 41270967] [0.03%]
关于“精氨酸代谢在骨骼健康和疾病中的新兴作用”的勘误(《代谢》杂志2025年11月19日第175卷156451页。/PMID:41270967)
Sibo Wang,Qian Ren,Yansheng Huang et al.
Sibo Wang et al.
Aging and metabolism in HFpEF: Pathophysiology and therapeutic implications [0.03%]
射血分数保留型心力衰竭(HFpEF)的衰老与代谢：病理生理和治疗意义
Min Ye,Shenghui Feng,Zixuan Xu et al.
Min Ye et al.
Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as an age-predominant syndrome characterized by diastolic dysfunction despite preserved systolic performance. In the aged myocardium, fatty acid oxidation cap...
Epicardial adipose tissue produces L-3-hydroxybutyrate in advanced heart failure: direct analysis of fat metabolic remodeling [0.03%]
心力衰竭时心脏外膜脂肪组织产生L-3-羟基丁酸离子：直接分析脂肪代谢重构
Martin Riecan,Barbora Judita Kasperova,Michaela Vondrackova et al.
Martin Riecan et al.
Background: Heart failure (HF) progression involves complex metabolic and multi-organ alterations, but the specific adaptations in adipose tissue are not fully understood. ...
Effect of GLP-1 receptor agonists and co-agonists on atrial fibrillation risk in overweight or obesity: systematic review and meta-analysis of randomized controlled trials [0.03%]
葡萄糖依赖性促胰岛素多肽受体激动剂和协同激动剂对超重或肥胖患者房颤风险的影响：随机对照试验的系统评价和meta分析
Paschalis Karakasis,Konstantinos Vlachos,Antonios P Antoniadis et al.
Paschalis Karakasis et al.
Background and aims: Overweight and obesity represent major modifiable determinants of atrial fibrillation (AF) incidence and arrhythmia outcomes after AF ablation therapy. Glucagon-like peptide-1 receptor agonists (GLP-1...
Unravelling the obesity paradox in cancer: An umbrella review of protective associations and evidence credibility across 13 malignancies [0.03%]
解开肥胖悖论与癌症的关系：一项关于13种恶性肿瘤的保护性关联和证据可信度的伞式回顾研究
Lulin Yu,Jing Yuan,Mingxian Meng et al.
Lulin Yu et al.
Background: The "obesity paradox" in cancer remains controversial amid inconsistent meta-analyses. This umbrella review re-analyses evidence across 13 malignancies using pre-specified credibility criteria to clarify assoc...
FAM83A acts as an amplifier for lipogenic signaling to facilitate the pathogenesis of metabolic dysfunction-associated steatohepatitis [0.03%]
FAM83A通过放大脂生成信号促进代谢功能障碍相关steatohepatitis的发生发展
Yang Zhou,Yuhang Dai,Mengyao Qin et al.
Yang Zhou et al.
Background & aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) and its more severe manifestation, metabolic-associated steatohepatitis (MASH), are intimately linked to disturbances in lipid metabolism. Al...
Meteorin-like protein inhibits vascular smooth muscle cell-derived foam cell formation and atherosclerosis via KIT- endoplasmic reticulum stress signaling [0.03%]
气象素类似蛋白通过KIT-内质网应力信号通路抑制血管平滑肌细胞源泡沫细胞形成及动脉粥样硬化进展
Xu Chen,Xueying Jiang,Siyu Hou et al.
Xu Chen et al.
Objective: Vascular smooth muscle cell (VSMC)-derived foam cell formation is a major contributor to atherosclerosis progression and plaque instability. Meteorin-like protein (METRNL), a secreted organokine with known meta...
Molecular code of ferroptosis: emerging multi-dimensional modifications and therapeutic targets in hepatic disorders [0.03%]
铁死亡的分子代码：肝脏疾病中新兴的多维度修饰和治疗靶点
Xiaotong Cai,Yinhao Zhang,Wenqing Qin et al.
Xiaotong Cai et al.
Ferroptosis, a distinct form of iron-dependent cell death characterized by lipid peroxidation, has emerged as a pivotal regulator in the pathogenesis of liver diseases. It functions both as a driver of hepatocyte injury in chronic liver dis...
Imeglimin ameliorates MASLD by targeting PEN2 to activate AMPK pathway [0.03%]
依美格利明通过靶向PEN2激活AMPK通路以改善MASLD
Jinghe Li,Ruizhong Zhang,Xin Zeng et al.
Jinghe Li et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent and increasingly chronic liver disorder with increasing global incidence, closely linked to prolonged high-fat di...