Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1 [0.03%]
肝miR-93通过抑制SIRT1促进代谢功能障碍相关脂肪性肝病的发病机制
Yo Han Lee,Jinyoung Lee,Joonho Jeong et al.
Yo Han Lee et al.
Background and aims: The molecular mechanisms underlying metabolic dysfunction-associated steatotic liver disease (MASLD) remain largely unclear; however, emerging evidence suggests that microRNAs (miRNAs) play a critical...
Cross-sectional, interventional, and causal investigation of insulin sensitivity using plasma proteomics in diverse populations [0.03%]
基于血浆蛋白质组学的横断面、干预和因果分析以探究多个人群中的胰岛素敏感性
Pik Fang Kho,Neil Wary,Daniela Zanetti et al.
Pik Fang Kho et al.
Background: We previously reported significant correlations between a direct measure of insulin sensitivity (IS) and blood levels of proteins measured using the Proximity Extension Assay (PEA) in two European cohorts. How...
UBC9 ameliorates diabetic cardiomyopathy by modulating cardiomyocyte mitophagy through NEDD4/RUNX2/PSEN2 axis [0.03%]
UBC9通过调节NEDD4/RUNX2/PSEN2轴调控心肌细胞线粒体自噬从而改善糖尿病性心肌病
Hanlin Wu,Zheming Yang,Ting Zhou et al.
Hanlin Wu et al.
Aim: Diabetic cardiomyopathy (DCM) is one of the most significant cardiovascular complications in patients with diabetes. Ubiquitin conjugating enzyme 9 (UBC9) is the only SUMO-E2 enzyme that plays a key role in cardiomyo...
Leptin acutely increases hepatic triglyceride secretion in patients with lipodystrophy [0.03%]
leptin通过急性增加脂odyste病患者的肝三酰甘油分泌来升高血脂
Marianna Beghini,Matthäus Metz,Clemens Baumgartner et al.
Marianna Beghini et al.
Background and aims: Metreleptin ameliorates hepatic steatosis partially independent of its anorexic action. We previously showed that metreleptin increases hepatic very-low density lipoprotein triglycerides (VLDL1-TG) ex...
Mechanical activation of adipose tissue macrophages mediated by Piezo1 protects against diet-induced obesity by regulating sympathetic activity [0.03%]
Piezo1介导的机械活化脂肪组织巨噬细胞通过调节交感神经活性抵抗高脂饮食诱导的肥胖发生
Shaoqiu Leng,Xiaoyu Zhang,Ruxia Zhao et al.
Shaoqiu Leng et al.
Objective: Obesity-induced mechanical changes in white adipose tissue (WAT), including adipocyte hypertrophy and fibrosis, are hypothesized to alter adipose tissue macrophage (ATM) function through mechanosensitive pathwa...
Reconsidering KLK7's role in adipose inflammation: letter to the editor [0.03%]
关于KLK7在脂肪组织炎症中的作用的再思考——写给编辑部的一封信
Yaohui Zhong,Jiaqi Wei,Rui Jiang
Yaohui Zhong
Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state [0.03%]
细胞外HMGB1的氧化状态决定其能否传播衰老表型
Ji-Won Shin,Dong-Hyun Jang,So Young Kim et al.
Ji-Won Shin et al.
Background & purpose: Cellular senescence spreads systemically through blood circulation, but its mechanisms remain unclear. High mobility group box 1 (HMGB1), a multifunctional senescence-associated secretory phenotype (...
Prediction models for the implementation of precision medicine in the real world. Some critical issues [0.03%]
预测精准医学在现实世界中应用的模型。一些关键问题
Claudia Menzaghi,Massimiliano Copetti,Christos S Mantzoros et al.
Claudia Menzaghi et al.
Revisiting gender differences in obesity and type 2 diabetes: Letter to the editor [0.03%]
关于肥胖和2型糖尿病的性别差异问题致编辑信
Yaohui Zhong,Jiaqi Wei,Rui Jiang
Yaohui Zhong
Hexosamine biosynthesis dysfunction-induced LIFR N-glycosylation deficiency exacerbates steatotic liver ischemia/reperfusion injury [0.03%]
己糖胺生物合成功能障碍诱导的LIFR N-聚糖缺乏加剧了脂肪变性肝脏缺血/再灌注损伤
Ran Liu,Gengqiao Wang,Yongbing Qian et al.
Ran Liu et al.
Background: More and more steatotic livers undergo resection or transplantation but they exhibit higher susceptibility to ischemia-reperfusion injury (IRI), which results in increased perioperative complication morbidity ...