The S100 calcium-binding protein A11 promotes hepatic steatosis through RAGE-mediated AKT-mTOR signaling [0.03%]
S100钙结合蛋白A11通过RAGE介导的AKT-mTOR信号促进肝脂肪变性
Fei Teng,Jingjing Jiang,Jinhua Zhang et al.
Fei Teng et al.
Rationale: Nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease, has become an increasingly severe public health problem. However, the underlying mechanism for the occurrence and develo...
miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation [0.03%]
微 RNA-22 缺失限制白色脂肪细胞增殖并激活褐色脂肪组织以减轻高脂饮食诱导的肥胖积累
Vanessa M Lima,Jianming Liu,Bruna B Brandão et al.
Vanessa M Lima et al.
Background: Obesity, characterized by excessive expansion of white adipose tissue (WAT), is associated with numerous metabolic complications. Conversely, brown adipose tissue (BAT) and beige fat are thermogenic tissues th...
Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake [0.03%]
解偶联剂SHC517通过不影响摄食量逆转小鼠肥胖现象
Sing-Young Chen,Martina Beretta,Stephanie J Alexopoulos et al.
Sing-Young Chen et al.
Aims: Mitochondrial uncouplers decrease caloric efficiency and have potential therapeutic benefits for the treatment of obesity and related metabolic disorders. Herein we investigate the metabolic and physiologic effects ...
COVID-19 letter to the editor: Epicardial fat inflammation as possible enhancer in COVID-19? [0.03%]
关于SARS-CoV-2导致新冠肺炎的作者来信：心外膜脂肪组织炎症可能是新冠肺炎发病机制中的助推因素？
Yuhao Zhao,Mulei Chen,Xinchun Yang et al.
Yuhao Zhao et al.
Ge Yang,Jinlong Wei,Pinyi Liu et al.
Ge Yang et al.
Type 2 diabetes is the fastest-growing metabolic disease in the world. Many clinical studies have found that type 2 diabetes patients have metabolic disorders and chronic inflammatory states accompanied by disturbances in the gut microbiota...
Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1d/- mice [0.03%]
DNA修复缺陷型Ercc1d/-小鼠的胰岛素敏感性增强和胰腺β细胞功能减弱
Ana P Huerta Guevara,Sara J McGowan,Melissa Kazantzis et al.
Ana P Huerta Guevara et al.
Background: Type 2 diabetes (T2DM) is an age-associated disease characterized by hyperglycemia due to insulin resistance and decreased beta-cell function. DNA damage accumulation has been associated with T2DM, but whether...
AGEs exacerbates coronary microvascular dysfunction in NoCAD by activating endoplasmic reticulum stress-mediated PERK signaling pathway [0.03%]
糖基化末端产物通过激活内质网压力介导的PERK信号通路加重无冠脉病变患者的冠状微血管功能障碍
Zhongwei Liu,Haitao Zhu,Yanpeng Ma et al.
Zhongwei Liu et al.
Objective: The current study was aimed to investigate the involvement of endoplasmic reticulum stress (ERS)-mediated protein kinase R-like endoplasmic reticulum kinase (PERK) signaling in advanced glycation end products (...
Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype [0.03%]
低温暴露时褐色脂肪组织活性下降是人类节俭表型的代谢特征
Tim Hollstein,Karyne Vinales,Kong Y Chen et al.
Tim Hollstein et al.
Background: We recently demonstrated that thrifty subjects, characterized by a greater decrease in 24 h energy expenditure (24hEE) during short-term fasting, have less capacity for cold-induced thermogenesis (CIT) during ...
Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending? [0.03%]
线粒体动力学与非酒精性脂肪肝疾病（NAFLD）：童话结局的新视角？
Miriam Longo,Marica Meroni,Erika Paolini et al.
Miriam Longo et al.
Nonalcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver dysfunctions and it is predicted to become the primary cause of liver failure and hepatocellular carcinoma. Mitochondria are highly dynamic organelles involved in m...
Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters [0.03%]
依拉片诺改善金叙利亚仓鼠饮食诱导的非酒精性脂肪肝病伴射血分数保留的心力衰竭
François Briand,Julie Maupoint,Emmanuel Brousseau et al.
François Briand et al.
Background: Cardiovascular disease is the leading cause of deaths in nonalcoholic steatohepatitis (NASH) patients. Mouse models, while widely used for drug development, do not fully replicate human NASH nor integrate the ...