Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism [0.03%]
全球删除NTPDase3通过增加基础能量代谢来预防饮食诱导的肥胖
Bynvant Sandhu,Maria C Perez-Matos,Stephanie Tran et al.
Bynvant Sandhu et al.
Background: Ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), also known as CD39L3, is the dominant ectonucleotidase expressed by beta cells in the islet of Langerhans and on nerves. NTPDase3 catalyzes the con...
Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits [0.03%]
胰岛素降解酶对餐后胰岛素清除能力的丧失驱动了代谢紊乱_traits
Diego O Borges,Rita S Patarrão,Rogério T Ribeiro et al.
Diego O Borges et al.
Systemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player ...
Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study [0.03%]
人体组成对新冠肺炎易感性和严重性影响的两样本多变量孟德尔随机化研究
Dennis Freuer,Jakob Linseisen,Christa Meisinger
Dennis Freuer
Objectives: Recent studies suggested obesity to be a possible risk factor for COVID-19 disease in the wake of the coronavirus (SARS-CoV-2) infection. However, the causality and especially the role of body fat distribution...
João Victor Salgado,Miguel Angelo Goes,Natalino Salgado Filho
João Victor Salgado
The global nephrology community recognizes the increasing burden of kidney disease and its poor health outcomes in the general population. Given this, strategies to establish early diagnosis, improve understanding of the natural course and ...
Stergios A Polyzos,Christos S Mantzoros
Stergios A Polyzos
Weight and organ specific immune cell profiling of sleeve gastrectomy in mice [0.03%]
小鼠袖状胃切除术的体重和器官特异性免疫细胞谱型分析
David A Harris,Renuka Subramaniam,Todd Brenner et al.
David A Harris et al.
Objective: Sleeve gastrectomy (SG) has profound, immediate weight-loss independent effects on obesity related diabetes (T2D). Our prior studies have shown that immunologic remodeling may play a part in this metabolic impr...
DEC1 deficiency results in accelerated osteopenia through enhanced DKK1 activity and attenuated PI3KCA/Akt/GSK3β signaling [0.03%]
DEC1缺乏通过增强DKK1活性和减弱PI3KCA/Akt/GSK3β信号传导导致骨质疏松加速恶化
Shuangcheng He,Yu Guan,Yichen Wu et al.
Shuangcheng He et al.
Background: Human differentiated embryonic chondrocyte expressed gene 1 (DEC1) has been implicated in enhancing osteogenesis, a desirable outcome to counteract against deregulated bone formation such as retarded bone deve...
LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4 [0.03%]
富含LPS的代谢综合征患者小型细胞外囊泡通过激活TLR4诱导内皮功能障碍
Sakina Ali,Marine Malloci,Zainab Safiedeen et al.
Sakina Ali et al.
Background: Metabolic syndrome (MetS) is characterized by a cluster of interconnected risk factors -hyperglycemia, dyslipidemia, hypertension and obesity- leading to an increased risk of cardiovascular events. Small extra...
Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study [0.03%]
人正常血糖调节或2型糖尿病骨骼肌IRS1定量磷酸化蛋白质组学分析：病例对照研究
Håkan K R Karlsson,Akiko Kasahara,Mika Ikeda et al.
Håkan K R Karlsson et al.
Background & aims: The physiological regulation and contribution of the multiple phosphorylation sites of insulin receptor substrate 1 (IRS1) to the pathogenesis of insulin resistance is unknown. Our aims were to map the ...
Glucagon-like peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity [0.03%]
葡萄糖酸类似物通过调节肠FXR活性预防胆固醇胆结石形成
Zijing Zhang,Zuo Du,Qinhui Liu et al.
Zijing Zhang et al.
Background & aims: Cholesterol gallstone disease (CGD) is a common gastrointestinal disease. Liraglutide, an analogue of glucagon-like peptide 1, has been approved to treat type 2 diabetes. Clinical studies have suggested...