Insulin resistance, cardiovascular stiffening and cardiovascular disease [0.03%]
胰岛素抵抗、心血管僵硬与心血管疾病的关系
Michael A Hill,Yan Yang,Liping Zhang et al.
Michael A Hill et al.
The cardiometabolic syndrome (CMS) and obesity are typically characterized by a state of metabolic insulin resistance. As global and US rates of obesity increase there is an acceleration of the incidence and prevalence of insulin resistance...
FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice [0.03%]
fos/gos通过逆转小鼠的菌群失调、高肠道通透性和全身性炎症来缓解高脂饮食引起的骨丢失作用研究
Zheng Zhang,Tao Lin,Yichen Meng et al.
Zheng Zhang et al.
Background: Obesity and osteoporosis frequently coexist, and might have a causal relationship. Gut microbiota, associated with both lipid and bone metabolism, plays an important role in the pathogenesis of excessive fat a...
Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model [0.03%]
探讨11β-羟基类固醇脱氢酶Ⅰ型在多囊卵巢综合征发病机制中的作用及其选择性抑制的潜在治疗效果：一项临床前研究
Xinyu Li,Shuanggang Hu,Qinling Zhu et al.
Xinyu Li et al.
Background: Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrine disorder among reproductive-age women, and the leading cause of anovulatory infertility. 11β-hydroxysteroid dehydrogenases-1 (11β-H...
Statin use is associated with lower prevalence of advanced liver fibrosis in patients with type 2 diabetes [0.03%]
他汀类药物的使用与2型糖尿病患者晚期肝纤维化患病率较低有关
Stefano Ciardullo,Gianluca Perseghin
Stefano Ciardullo
Background: Patients with type 2 diabetes (T2D) are at increased risk of both cardiovascular disease (CVD) and advanced liver fibrosis related to non-alcoholic fatty liver disease (NAFLD). Statin use is known to reduce th...
Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy [0.03%]
NLRP3炎症小体抑制通过抑制脂质积聚缓解糖尿病肾病系膜细胞损伤
Ming Wu,Zhifen Yang,Chengyu Zhang et al.
Ming Wu et al.
Background: Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as a potent target for treating metabolic diseases and inflammatory disorders. Our recent work demonstrated that inhibition of NLRP3 infl...
The serum metabolome of COVID-19 patients is distinctive and predictive [0.03%]
具有预测性的COVID-19患者血清代谢组的特征
Ding Shi,Ren Yan,Longxian Lv et al.
Ding Shi et al.
Background: Metabolism is critical for sustaining life, immunity and infection, but its role in COVID-19 is not fully understood. Methods: ...
Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway [0.03%]
载脂蛋白C3通过激活肾脏TLR2/NF-κB途径加重1型糖尿病肾病
Huan Wang,Xiaomin Huang,Pengfei Xu et al.
Huan Wang et al.
Objective: Apolipoprotein C3 (ApoC3) is a regulator of triglyceride metabolism and inflammation, and its plasma levels are positively correlated with the progression of diabetic nephropathy (DN) in patients. However, the ...
Potential impact of Helicobacter pylori-related metabolic syndrome and Galectin-3 on liver, chronic kidney and brain disorders [0.03%]
Helicobacter pylori相关代谢综合征及Galectin-3对肝、慢性肾和脑疾病潜在影响
Marina Boziki,Stergios A Polyzos,Apostolis Papaefthymiou et al.
Marina Boziki et al.
The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in β-cells [0.03%]
MafA靶基因PPP1R1A调节GLP1R介导的β细胞葡萄糖刺激胰岛素分泌放大作用
Luis Rodrigo Cataldo,Neelanjan Vishnu,Tania Singh et al.
Luis Rodrigo Cataldo et al.
The amplification of glucose-stimulated insulin secretion (GSIS) through incretin signaling is critical for maintaining physiological glucose levels. Incretins, like glucagon-like peptide 1 (GLP1), are a target of type 2 diabetes drugs aimi...
Beyond mitochondria: Alternative energy-producing pathways from all strata of life [0.03%]
超越线粒体：来自生命各个层面的替代产能途径
Christopher Auger,Roohi Vinaik,Vasu D Appanna et al.
Christopher Auger et al.
It is well-established that mitochondria are the powerhouses of the cell, producing adenosine triphosphate (ATP), the universal energy currency. However, the most significant strengths of the electron transport chain (ETC), its intricacy an...