Collagen β(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice [0.03%]
胶原β（1-O）半乳糖转移酶2缺陷促进小鼠脂代谢障碍并加重与高分子量脂联素相关的非酒精性脂肪肝疾病
Junru Yang,Lingling He,Meixin Gao et al.
Junru Yang et al.
Aim: Our previous results showed that Colgalt1 knock-out resulted in fetal death on day E11.5, and collagen secretion was retarded. This study aimed to elucidate the role of Collagen β(1-O) galactosyltransferase 2 (Colga...
Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk [0.03%]
非酒精性脂肪肝、胰岛素抵抗和代谢综合征及其与血管风险的关系
Emir Muzurović,Dimitri P Mikhailidis,Christos Mantzoros
Emir Muzurović
The prevalence of non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases, is rising. About 25% of adults worldwide are probably affected by NAFLD. Insulin resistance (IR) and fat accumulation in the liver are stron...
Determinants of hepatic insulin clearance - Results from a Mendelian Randomization study [0.03%]
肝胰岛素清除率的决定因素-来自孟德尔随机化研究的结果
Apostolia Lamprinou,Caroline Willmann,Jürgen Machann et al.
Apostolia Lamprinou et al.
Aims/hypothesis: Besides insulin resistance, type 2 diabetes associates with decreased hepatic insulin clearance (HIC). We now tested for causal relationship of HIC to liver fat accumulation or features of the metabolic s...
Anna Goddi,Liesl Schroedl,Eric M Brey et al.
Anna Goddi et al.
Laminins are extracellular matrix proteins that reside in the basement membrane and provide structural support in addition to promoting cellular adhesion and migration. Through interactions with cell surface receptors, laminins stimulate in...
Diabetes in pregnancy 100 years after the discovery of insulin: Hot topics and open questions to be addressed in the coming years [0.03%]
胰岛素发现一百年后的妊娠糖尿病：未来几年亟待解决的重要问题和热点议题
Ravi Retnakaran
Ravi Retnakaran
By making it possible for women with diabetes to achieve their family planning goals, the discovery of insulin ushered in the field of diabetes in pregnancy. The ensuing century has witnessed tremendous advances, with clinical focus on prec...
Early benefits of bariatric surgery on subclinical cardiac function: Contribution of visceral fat mobilization [0.03%]
胃旁路手术对心脏亚临床功能的早期益处：腹腔内脂肪动员的贡献
Marie-Eve Piché,Marie-Annick Clavel,Audrey Auclair et al.
Marie-Eve Piché et al.
Aims: We explored the early effects of bariatric surgery on subclinical myocardial function in individuals with severe obesity and preserved left ventricular (LV) ejection fraction. ...
Mebhydrolin ameliorates glucose homeostasis in type 2 diabetic mice by functioning as a selective FXR antagonist [0.03%]
Mebhydrolin通过作用于FXR选择性拮抗剂改善2型糖尿病小鼠的葡萄糖稳态
Tong Zhao,Jie Wang,Anxu He et al.
Tong Zhao et al.
Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disease with hallmarks of hyperglycemia and hyperlipidemia. Long-term hyperglycemia damages the functions of multiple tissues and organs leading to a series of co...
COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic [0.03%]
新冠肺炎疫情下代谢性疾病的发病机制及治疗挑战——基于一年抗疫经验的思考与展望編輯部論文
Christopher M Tessier,Alexander Kokkinos,Geltrude Mingrone et al.
Christopher M Tessier et al.
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice [0.03%]
MiR-337-3p通过靶向PCSK9降低高脂血症小鼠的LDL-C水平
Xiaoding Xu,Yunxia Dong,Ningning Ma et al.
Xiaoding Xu et al.
Background: Reducing serum low-density lipoprotein cholesterol (LDL-C) in hyperlipemia is recognized as an effective strategy to minimize the risk of atherosclerotic cardiovascular disease (ASCVD). MiR-337-3p has already ...
The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis [0.03%]
维生素D与冠状病毒疾病2019之间关联的系统评价和meta分析（VIVID）
Aya Bassatne,Maya Basbous,Marlene Chakhtoura et al.
Aya Bassatne et al.
Background: Disease severity and mortality rates due to COVID-19 infection are greater in the elderly and chronically ill patients, populations at high risk for vitamin D deficiency. Vitamin D plays an important role in i...