Long-term statin treatment for hepatic fibrosis in patients with nonalcoholic fatty liver disease: Is it time to give the emperor a statin robe? [0.03%]
非酒精性脂肪肝病患者肝纤维化的长期他汀治疗：是时候让“皇帝的新装”着衣了吗？
Christopher M Tessier,Stergios A Polyzos,Vasilios G Athyros et al.
Christopher M Tessier et al.
Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy [0.03%]
PPARα激动剂非诺贝特通过上调TFEB介导的脂质自噬减少肝脏脂肪蓄积
Jin Yoo,In-Kyung Jeong,Kyu Jeung Ahn et al.
Jin Yoo et al.
Background: Recent studies have shown that dysregulation of autophagy is involved in the development of nonalcoholic fatty liver disease (NAFLD). Transcription factors E3 (TFE3) and EB (TFEB) are master regulators of the ...
A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage [0.03%]
一种治疗NASH的新机制：奥贝胆酸通过抑制巨噬细胞中NLRP3炎性小体的活化发挥作用
Suling Huang,Yanwei Wu,Zhuohui Zhao et al.
Suling Huang et al.
Objective: Obeticholic acid (OCA) has been proved to play potential therapeutic effect on nonalcoholic steatohepatitis (NASH). Up to now, the study of OCA on NLRP3 inflammasome activation in macrophage is still blank and ...
A longitudinal analysis of arterial stiffness and wave reflection in preeclampsia: Identification of changepoints [0.03%]
子痫前期动脉僵硬度和波反射的纵向分析：变化点的识别
Kim Phan,Ian Schiller,Nandini Dendukuri et al.
Kim Phan et al.
Purpose: Preeclampsia (PrE) is a leading complication of pregnancy characterized by vascular dysfunction. Characterizing the longitudinal changes in vascular function prior to PrE onset is critical to the identification o...
Understanding the increased risk of infections in diabetes: innate and adaptive immune responses in type 1 diabetes [0.03%]
理解糖尿病感染风险增加：1型糖尿病的先天性和适应性免疫反应
Anna W M Janssen,Rinke Stienstra,Martin Jaeger et al.
Anna W M Janssen et al.
Aims: Patients with diabetes have a higher incidence of infections with Candida albicans, Staphylococcus aureus and Mycobacterium tuberculosis, yet factors contributing to this increased risk are largely unknown. We hypot...
Yimin Shen,Yuhao Zhang,Wudi Li et al.
Yimin Shen et al.
Glutamine is a major energy source for rapidly dividing cells, such as hematopoietic stem cells and cancer cells. Reliance on glutamine is therefore regarded as a metabolic hallmark of proliferating cells. Moreover, reprogramming glutamine ...
Addressing the epidemic of fatty liver disease: A call to action, a call to collaboration, a call to moving the field forward [0.03%]
应对脂肪肝病流行：行动起来，协同起来，发展起来
Chrysoula Boutari,Stergios A Polyzos,Christos S Mantzoros
Chrysoula Boutari
The progression and regression of metabolic dysfunction-associated fatty liver disease are associated with the development of subclinical atherosclerosis: A prospective analysis [0.03%]
代谢紊乱相关非酒精性脂肪肝病的进展和逆转与亚临床动脉粥样硬化的发展有关：前瞻性分析
Shanshan Liu,Jialu Wang,Shujing Wu et al.
Shanshan Liu et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed and diagnosed based on modified criteria. However, evidence for the risks of developing subclinical atherosclerosis with MAFLD tra...
Thiazolidinediones, alpha-glucosidase inhibitors, meglitinides, sulfonylureas, and hepatocellular carcinoma risk: A meta-analysis [0.03%]
噻唑烷二酮、α-葡萄糖苷酶抑制剂、美格列奈和磺脲类药物与肝细胞癌风险：一项荟萃分析研究
Ashwini Arvind,Zoe N Memel,Lisa L Philpotts et al.
Ashwini Arvind et al.
Background & aims: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death worldwide. Effects of second-line oral antidiabetic medications on incident HCC risk in individuals with type 2 diabetes me...
Corrigendum to "Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults" [Metab Clin Exp 112 (2020) 154356] [0.03%]
关于“果糖和葡萄糖对心血管疾病青年危险因素的协同作用”的勘误说明(MetabClinExp112(2020)154356)
Bettina Hieronimus,Valentina Medici,Andrew A Bremer et al.
Bettina Hieronimus et al.