Irisin in nonalcoholic fatty liver disease: Need for an updated meta-analysis [0.03%]
非酒精性脂肪肝病中irisin的研究：需要进行更新的荟萃分析
Stergios A Polyzos,Jannis Kountouras,Athanasios D Anastasilakis
Stergios A Polyzos
Circulating α-klotho regulates metabolism via distinct central and peripheral mechanisms [0.03%]
循环α-甘油磷脂酶通过不同的中枢和外周机制调节代谢
Taylor Landry,Daniel Shookster,Hu Huang
Taylor Landry
Emerging evidence implicates the circulating α-klotho protein as a prominent regulator of energy balance and substrate metabolism, with diverse, tissue-specific functions. Despite its well-documented ubiquitous role inhibiting insulin sign...
Raymond Pranata,Joshua Henrina,Wilson Matthew Raffaello et al.
Raymond Pranata et al.
Diabetes, one of the most prevalent chronic diseases in the world, is strongly associated with a poor prognosis in COVID-19. Scrupulous blood sugar management is crucial, since the worse outcomes are closely associated with higher blood sug...
Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity [0.03%]
缺四点五LIM结构域蛋白2（FHL2）小鼠抗饮食诱导肥胖及人肥胖标志物FHL2高表达
Maria P Clemente-Olivo,Jayron J Habibe,Mariska Vos et al.
Maria P Clemente-Olivo et al.
Objective: Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In humans, methylation and expression of the FHL2 gene in...
Cristian Loretelli,Francesca Rocchio,Francesca D&#x;Addio et al.
Cristian Loretelli et al.
Aims/hypothesis: Inflammation has a major role in diabetic kidney disease. We thus investigated the role of the IL-8-CXCR1/2 axis in favoring kidney damage in diabetes. ...
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans [0.03%]
脂质通过激活骨骼肌线粒体分裂和质量控制通路诱导人类胰岛素抵抗
Christopher L Axelrod,Ciaran E Fealy,Melissa L Erickson et al.
Christopher L Axelrod et al.
Background and aims: A diminution in skeletal muscle mitochondrial function due to ectopic lipid accumulation and excess nutrient intake is thought to contribute to insulin resistance and the development of type 2 diabete...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2021 Aug:121:154803. DOI:10.1016/j.metabol.2021.154803 2021
Molecular mechanisms underlying hepatitis C virus infection-related diabetes [0.03%]
丙型肝炎病毒感染相关糖尿病发病的分子机制研究进展
Yujin Ding,Guangdi Li,Zhiguang Zhou et al.
Yujin Ding et al.
Diabetes is a noncommunicable widespread disease that poses the risk of severe complications in patients, with certain complications being life-threatening. Hepatitis C is an infectious disease that mainly causes liver damage, which is also...
Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1 [0.03%]
黏蛋白CEACAM1调节肝纤维化及其相关炎症反应
Raghd Abu Helal,Lucia Russo,Hilda E Ghadieh et al.
Raghd Abu Helal et al.
Objective: NAFLD is a complex disease marked by cellular abnormalities leading to NASH. NAFLD patients manifest low hepatic levels of CEACAM1, a promoter of insulin clearance. Consistently, Cc1-/- null mice displayed spon...
Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells [0.03%]
载脂蛋白C-Ⅲ诱导的高脂血症中NK细胞活性下调由脂质代谢重编程及泡沫细胞样树突状细胞介导
Xiangyu Hu,Xiaoqin Jia,Cong Xu et al.
Xiangyu Hu et al.
Objective: Apolipoprotein C-III (Apoc3) is a key component of triglyceride-rich lipoproteins (TRL). The Apoc3-transgenic mice are characterized by high levels of plasma triglyceride and free fatty acids (FFAs). Apoc3 stim...
Diabetes and kidney disease: emphasis on treatment with SGLT-2 inhibitors and GLP-1 receptor agonists [0.03%]
糖尿病与肾脏病：SGLT-2抑制剂和GLP-1受体激动剂治疗的强调
Francesco Prattichizzo,Paola de Candia,Antonio Ceriello
Francesco Prattichizzo
Kidney disease is a frequent microvascular complication of both type 1 and type 2 diabetes. Historic trials have demonstrated that a tight glycaemic control is the most powerful approach to decrease the chances of developing diabetic nephro...