Incretin-based therapies in 2021 - Current status and perspectives for the future [0.03%]
2021年肠泌肽类治疗的现状与未来展望
Manfredi Rizzo,Michael A Nauck,Christos S Mantzoros
Manfredi Rizzo
Diabetic ketoacidosis in pediatric patients with type 1- and type 2 diabetes during the COVID-19 pandemic [0.03%]
新冠肺炎流行期间1型和2型糖尿病患儿的糖尿病酮症酸中毒
Charlotte Loh,Paul Weihe,Nicole Kuplin et al.
Charlotte Loh et al.
Background: COVID-19 pandemic caused families to stay home and cancel everyday activities. Hospital admissions decreased, affecting changes in diagnoses and management of chronic disease in children. ...
The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity [0.03%]
肥胖对长期禁食下纹状体五-羟色胺转运蛋白的可获得性的影响减弱
Katy A van Galen,Jan Booij,Anouk Schrantee et al.
Katy A van Galen et al.
Background and aims: Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting influ...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2021 Oct:123:154839. DOI:10.1016/j.metabol.2021.154839 2021
FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis [0.03%]
FUNDC1缺乏通过ACSL4介导的铁死亡促进高脂饮食诱发的心脏重构和收缩功能异常
Zhaohui Pei,Yandong Liu,Suqin Liu et al.
Zhaohui Pei et al.
Objective: Ferroptosis is indicated in cardiovascular diseases. Given the prominent role of mitophagy in the governance of ferroptosis and our recent finding for FUN14 domain containing 1 (FUNDC1) in obesity anomalies, th...
Bone morphogenetic proteins (BMPs) in the central regulation of energy balance and adult neural plasticity [0.03%]
骨形态发生蛋白(BMPs)在中枢能量平衡和成人神经可塑性调节中的作用
Gabriel S Jensen,Noelle E Leon-Palmer,Kristy L Townsend
Gabriel S Jensen
The current worldwide obesity pandemic highlights a need to better understand the regulation of energy balance and metabolism, including the role of the nervous system in controlling energy intake and energy expenditure. Neural plasticity i...
Fasiha Kanwal,Jay H Shubrook,Zobair Younossi et al.
Fasiha Kanwal et al.
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are common conditions with a rising burden. Yet there are significant management gaps between clinical guidelines and practice in patients with NAFLD and NASH....
Exosomes: Advances, development and potential therapeutic strategies in diabetic nephropathy [0.03%]
外泌体：糖尿病肾病研究进展、开发及其潜在治疗策略
Jingfang Chen,Qing Zhang,Dongwei Liu et al.
Jingfang Chen et al.
Exosomes, a major type of extracellular vesicles (EVs), are nanoscale vesicles excreted by almost all cell types via invagination of the endosomal membrane pathway. Exosomes play a crucial role in the mediation of intercellular communicatio...
Suppressor of cytokine signalling-2 controls hepatic gluconeogenesis and hyperglycemia by modulating JAK2/STAT5 signalling pathway [0.03%]
细胞因子信号抑制蛋白-2通过调节JAK2/STAT5信号通路控制肝糖异生和高血糖症
Xu Zhang,Yuan Zhuang,Tian Qin et al.
Xu Zhang et al.
Hepatic gluconeogenesis plays a crucial role in maintaining blood glucose homeostasis in mammals. Globe knockout of suppressor of cytokine signalling-2 (SOCS2), a feedback inhibitor of cytokine signalling, has been shown resistant to high-f...
Non-glucose modulators of insulin secretion in healthy humans: (dis)similarities between islet and in vivo studies [0.03%]
健康人类胰岛素分泌的非葡萄糖调节因子：离体和整体研究的异同点分析
Jean-Claude Henquin
Jean-Claude Henquin
Optimal metabolic homeostasis requires precise temporal and quantitative control of insulin secretion. Both in vivo and in vitro studies have often focused on the regulation by glucose although many additional factors including other nutrie...
An updated meta-analysis on the relationship between obesity and COVID-19 mortality [0.03%]
一项关于肥胖与新冠死亡率关系的更新型meta分析
Yadong Wang,Jie Xu,Ying Wang et al.
Yadong Wang et al.