Ischemic heart failure mortality is not predicted by cardiac insulin resistance but by diabetes per se and coronary flow reserve: A retrospective dynamic cardiac 18F-FDG PET study [0.03%]
心肌葡萄糖摄取与缺血性心力衰竭患者的死亡率：一项动态心脏氟-18脱氧葡萄糖正电子发射断层扫描的回顾性研究
Thien Vinh Luong,Mette Glavind Bülow Pedersen,Mette Louise Blouner Gram Kjærulff et al.
Thien Vinh Luong et al.
Background & aims: The connection between peripheral insulin resistance (IR) and coronary artery disease is well-established. Both are major risk factors for the development of ischemic cardiomyopathy potentially leading ...
Rheb1 promotes glucose-stimulated insulin secretion in human and mouse β-cells by upregulating GLUT expression [0.03%]
Rheb1通过上调GLUT表达促进人和小鼠胰岛β细胞的葡萄糖刺激的胰岛素分泌
Yan Yang,Zixin Cai,Zhenhong Pan et al.
Yan Yang et al.
Reduced β-cell mass and impaired β-cell function are primary causes of all types of diabetes. However, the intrinsic molecular mechanism that regulates β-cell growth and function remains elusive. Here, we demonstrate that the small GTPas...
Association of prediabetes, diabetes, and diabetes duration with biliary tract cancer risk: A nationwide cohort study [0.03%]
糖尿病前期、糖尿病及其病程与胆道癌风险的关系：一项全国队列研究
Joo-Hyun Park,Jung Yong Hong,Young Suk Park et al.
Joo-Hyun Park et al.
Background & aims: Population-based evidence of the association between diabetes and biliary tract cancer (BTC) risk is lacking. We aimed to evaluate the association of prediabetes, diabetes, and diabetes duration with su...
Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake [0.03%]
乙酰辅酶A胆固醇酰基转移酶的药理学抑制通过调节摄食量缓解饮食诱导型肥胖小鼠的肥胖和胰岛素抵抗
Yuyan Zhu,Sora Q Kim,Yuan Zhang et al.
Yuyan Zhu et al.
Background/objectives: Acyl-coenzyme A:cholesterol acyltransferases (ACATs) catalyze the formation of cholesteryl ester (CE) from free cholesterol to regulate intracellular cholesterol homeostasis. Despite the well-docume...
Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis [0.03%]
卵巢功能不全通过激活下丘脑从头合成酰鞘氨醇的途径损害葡萄糖刺激的胰岛素分泌
Kelly Meneyrol,Ánxela Estévez-Salguero,Ismael González-García et al.
Kelly Meneyrol et al.
Oestrogens regulate body weight through their action on hypothalamus to modulate food intake and energy expenditure. Hypothalamic de novo ceramide synthesis plays a central role on obesity induced by oestrogen deficiency. Depletion in oestr...
Thromboembolism risk among patients with diabetes/stress hyperglycemia and COVID-19 [0.03%]
糖尿病/应激性高血糖COVID-19患者的血栓栓塞风险
Stefania L Calvisi,Giuseppe A Ramirez,Marina Scavini et al.
Stefania L Calvisi et al.
Purpose: Individuals with diabetes/stress hyperglycemia carry an increased risk for adverse clinical outcome in case of SARS-CoV-2 infection. The purpose of this study was to evaluate whether this risk is, at least in par...
Atypical antipsychotic drugs deregulate the cholesterol metabolism of macrophage-foam cells by activating NOX-ROS-PPARγ-CD36 signaling pathway [0.03%]
非典型抗精神病药通过激活巨噬细胞泡沫细胞中的NOX-ROS-PPARγ-CD36信号通路而扰乱胆固醇代谢
Chia-Hui Chen,Shr-Jeng Jim Leu,Chiao-Po Hsu et al.
Chia-Hui Chen et al.
Background: Clinical reports indicate that schizophrenia patients taking atypical antipsychotic drugs suffer from metabolism diseases including atherosclerosis. However, the mechanisms underlying the detrimental effect of...
Intestine-liver crosstalk in Type 2 Diabetes and non-alcoholic fatty liver disease [0.03%]
2型糖尿病和非酒精性脂肪肝病下的肠肝对话机制探究
Margaux Nawrot,Simon Peschard,Sophie Lestavel et al.
Margaux Nawrot et al.
Type 2 diabetes (T2D) and Non-Alcoholic Fatty Liver Disease (NAFLD) are pathologies whose prevalence continues to increase worldwide. Both diseases are precipitated by an excessive caloric intake, which promotes insulin resistance and fatty...
Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes [0.03%]
2型糖尿病流行病学中心血管疾病及心血管风险防控的现状与趋势分析
Jae-Seung Yun,Seung-Hyun Ko
Jae-Seung Yun
With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) has been decreasing over past decades. However, given that CVD is still a major cause of death in patien...
T-T Trinh,H Blasco,F Maillot et al.
T-T Trinh et al.
Inherited metabolic disorders (IMDs) have been observed in individuals with hearing loss (HL), but IMDs are rarely the cause of syndromic HL. With early diagnosis, management of HL is more effective and cortical reorganization is possible w...