The β-cell glucose toxicity hypothesis: Attractive but difficult to prove [0.03%]
β细胞葡萄糖毒性的假说：具有吸引力但难以证实
Gordon C Weir,Peter C Butler,Susan Bonner-Weir
Gordon C Weir
β cells in the hyperglycemic environment of diabetes have marked changes in phenotype and function that are largely reversible if glucose levels can be returned to normal. A leading hypothesis is that these changes are caused by the elevat...
Thibault Gautier,Leah B Ziegler,Matthew S Gerber et al.
Thibault Gautier et al.
Artificial intelligence (AI) is widely discussed in the popular literature and is portrayed as impacting many aspects of human life, both in and out of the workplace. The potential for revolutionizing healthcare is significant because of th...
Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk [0.03%]
饮食和运动可减轻已经存在的NASH和纤维化，并通过器官间的相互作用对血管、脂肪组织和骨骼肌产生额外的有益影响
Anita M van den Hoek,Jelle C B C de Jong,Nicole Worms et al.
Anita M van den Hoek et al.
Background: Non-alcoholic steatohepatitis (NASH) has become one of the most common liver diseases and is still without approved pharmacotherapy. Lifestyle interventions using exercise and diet change remain the current tr...
Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart [0.03%]
BCATm缺失增加心脏对胰岛素刺激的葡萄糖氧化作用
Golam M Uddin,Qutuba G Karwi,Simran Pherwani et al.
Golam M Uddin et al.
Backgrounds: Branched chain amino acid (BCAA) oxidation is impaired in cardiac insulin resistance, leading to the accumulation of BCAAs and the first products of BCAA oxidation, the branched chain ketoacids. However, it i...
Glucose transporter 3 in neuronal glucose metabolism: Health and diseases [0.03%]
神经元葡萄糖代谢中的葡萄糖转运蛋白3：健康与疾病
Wuxue Peng,Changhong Tan,Lijuan Mo et al.
Wuxue Peng et al.
Neurons obtain glucose from extracellular environment for energy production mainly depending on glucose transporter 3 (GLUT3). GLUT3 uptakes glucose with high affinity and great transport capacity, and is important for neuronal energy metab...
Simona Cernea,Itamar Raz
Simona Cernea
Diabetic neuropathy is a neurodegenerative disorder that may alter both the somatic and autonomic peripheral nervous systems in the context of diabetes mellitus (DM). It is a prevalent and burdensome chronic complication of DM, that require...
Nonalcoholic fatty liver disease increases the risk of diabetes in young adults: A nationwide population-based study in Korea [0.03%]
非酒精性脂肪肝增加韩国年轻人糖尿病风险：一项基于全国人口的队列研究
Goh Eun Chung,Eun Ju Cho,Ji Won Yoon et al.
Goh Eun Chung et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of diabetes but has been rarely investigated in young adults. In this study, we investigated the relationship between NAFLD and inc...
Timothy M E Davis
Timothy M E Davis
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a relatively novel classification which downplays the importance of alcohol in the definition of non-alcoholic fatty liver disease (NAFLD) and emphasizes the metabolic risk fac...
AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle [0.03%]
AMP脱氨基作用足以在骨骼肌中复制类似萎缩的代谢表型
Spencer G Miller,Paul S Hafen,Andrew S Law et al.
Spencer G Miller et al.
Background: Skeletal muscle atrophy, whether caused by chronic disease, acute critical illness, disuse or aging, is characterized by tissue-specific decrease in oxidative capacity and broad alterations in metabolism that ...
Dietary carbohydrate intake and new-onset diabetes: A nationwide cohort study in China [0.03%]
中国全国性队列研究：膳食碳水化合物摄入与新发糖尿病的关系
Chun Zhou,Zhuxian Zhang,Mengyi Liu et al.
Chun Zhou et al.
Aim: The association of carbohydrate intake with diabetes risk remains uncertain. We aimed to evaluate the prospective associations of the amount and types of carbohydrate intake with new-onset diabetes. ...