The presence of NAFLD influences the transition of metabolically healthy to metabolically unhealthy obesity and the ten-year cardiovascular disease risk: A population-based cohort study [0.03%]
非酒精性脂肪肝的存在影响代谢健康向代谢不健康肥胖的转变以及十年心血管疾病风险：一项基于人群的队列研究
Matina Kouvari,Christina Chrysohoou,John Skoumas et al.
Matina Kouvari et al.
Background/objectives: We evaluated the role of the presence of non-alcoholic fatty liver disease (NAFLD) at baseline in the transition from metabolically healthy to metabolically unhealthy obesity (MHO to MUO) ten years ...
Metabolically unhealthy individuals, either with obesity or not, have a higher risk of critical coronavirus disease 2019 outcomes than metabolically healthy individuals without obesity [0.03%]
与没有肥胖的代谢健康个体相比，无论是肥胖与否，代谢不健康的人都有更高的风险出现严重的新冠肺炎结果。
Nam Hoon Kim,Kyeong Jin Kim,Jimi Choi et al.
Nam Hoon Kim et al.
Background: This study aimed to determine the relative and independent contributions of impaired metabolic health and obesity to critical coronavirus disease 2019 (COVID-19). ...
Vascular effects of insulin [0.03%]
胰岛素的血管效应
Andrea Natali,Lorenzo Nesti
Andrea Natali
Lucia Mastrototaro,Michael Roden
Lucia Mastrototaro
Insulin resistance is a common feature of obesity and type 2 diabetes, but novel approaches of diabetes subtyping (clustering) revealed variable degrees of insulin resistance in people with diabetes. Specifically, the severe insulin resista...
Kidney disease in diabetes: From mechanisms to clinical presentation and treatment strategies [0.03%]
糖尿病肾脏疾病：从机制到临床表现和治疗策略
Carlo Alberto Ricciardi,Luigi Gnudi
Carlo Alberto Ricciardi
Metabolic and haemodynamic perturbations and their interaction drive the development of diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD). Increased mitochondrial oxidative stress has been proposed as ...
Philip Home
Philip Home
Insulin therapy has a long history at the cutting edge of technological development through purification, extended-action, molecular chemistry, and devices, and in support technologies including self-measurement and patient education. But u...
Non-alcoholic fatty liver disease, metabolic goal achievement with incident cardiovascular disease and eGFR-based chronic kidney disease in patients with prediabetes and diabetes [0.03%]
非酒精性脂肪肝病，代谢目标的实现与新发心血管疾病和eGFR为基础的慢性肾脏病在糖尿病前期和糖尿病患者中的关系
Mian Li,Zhiyun Zhao,Guijun Qin et al.
Mian Li et al.
Aims/hypothesis: We aimed to evaluate the effect of NAFLD on the risk of incident cardiovascular disease (CVD) and estimated glomerular filtration rate (eGFR)-based chronic kidney disease (CKD), and further test the joint...
ApoA-I mimetics favorably impact cyclooxygenase 2 and bioactive lipids that may contribute to cardiometabolic syndrome in chronic treated HIV [0.03%]
apoA-I模拟物对治疗性HIV慢性疾病中影响环氧化酶2和生物活性脂质的研究可能会促进心血管代谢综合征的发展
M Daskou,M Sharma,W Mu et al.
M Daskou et al.
Objective: We investigated whether apolipoprotein A-I (apoA-I) mimetic peptides 4F and 6F can be a novel therapeutic strategy to reduce blood and gut bioactive lipids, proinflammatory effects of endotoxin (LPS) and aberra...
Unravelling lipoprotein metabolism with stable isotopes: tracing the flow [0.03%]
用稳定同位素研究脂蛋白代谢：流速测定
Qidi Ying,Dick C Chan,P Hugh R Barrett et al.
Qidi Ying et al.
Dysregulated lipoprotein metabolism is a major cause of atherosclerotic cardiovascular disease (ASCVD). Use of stable isotope tracers and compartmental modelling have provided deeper understanding of the mechanisms underlying lipid disorder...
Metabolic improvement after gastric bypass correlates with changes in IGF-regulatory proteins stanniocalcin-2 and IGFBP-4 [0.03%]
胃旁路术后代谢改善与IGF调节蛋白stanniocalcin-2和IGFBP-4的变化相关
Rikke Hjortebjerg,Kirstine N Bojsen-Møller,Mette Søeby et al.
Rikke Hjortebjerg et al.
Background: Pregnancy-associated plasma protein-A (PAPP-A) is an enzyme that increases IGF-activity through cleavage of IGF-binding proteins (IGFBPs), primarily IGFBP-4, whereby bound IGF-I becomes released as a free mole...