TRP channels at the crossroads of metabolism and immunity: ion-metabolite coupling in inflammation and disease [0.03%]
代谢和免疫的十字路口：炎症和疾病中的离子-代谢物偶联
De-Hua Liao,Shi-Long Jiang,Ting Wu et al.
De-Hua Liao et al.
Transient receptor potential (TRP) channels are not only multimodal ion sensors but also couplers between metabolic states and immune responses. TRP gating is controlled by lipid signaling (PIP2, DAG, cholesterol), redox/energy cues (NAD+/A...
Suppression of hepatosteatosis by isarubrolone C through AMPK-dependent regulation of lipophagy and lipid metabolism [0.03%]
依沙红酮C通过AMPK依赖性调节脂自噬和脂质代谢抑制肝脂肪变性
Bo Chen,Yuan-Yuan Ma,Miao-Qing Zhang et al.
Bo Chen et al.
Targeting autophagy and fatty acid metabolism may be two promising therapeutic strategies for treating metabolic dysfunction-associated steatotic liver disease (MASLD). Our previous research demonstrated the ability of isarubrolone C (IroC)...
CADD-engineered peptide protacs efficiently target PCSK9 for hypercholesterolemia in vivo [0.03%]
基于计算的脯氨酸富集肽PROTAC高效体内降解PCSK9蛋白以治疗高胆固醇血症
Gang Fan,Weiming Guo,Jingfen Lu et al.
Gang Fan et al.
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of low-density lipoprotein receptors (LDLR), leading to elevated plasma LDL cholesterol (LDL-C) and increased risk of hypercholest...
Andrea Giustina,Luigi di Filippo,Aneta Aleksova et al.
Andrea Giustina et al.
The 8th International Conference Controversies in Vitamin D, held in September 2024, convened leading experts to address the multifaceted role of vitamin D in human health. Key discussions focused on its influence on metabolic health, inclu...
The SEMA7AN559Y mutation facilitates the development of metabolic dysfunction-associated steatotic liver disease by inducing ROS/NLRP3-mediated hepatic cell pyroptosis [0.03%]
SEMA7A的SEM7AN559Y突变通过诱导ROS/NLRP3介导的肝细胞焦亡促进代谢功能紊乱相关脂肪性肝病的发展
Xiaoxun Zhang,Jiaxin Lei,Nan Zhao et al.
Xiaoxun Zhang et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver condition that can result in significant liver damage. This study aimed to evaluate the effects of the SEMA7A...
The ACSL family: Bridging fatty acid metabolism and cell death in cancer progression [0.03%]
ACSL家族：脂肪酸代谢和癌细胞死亡之间的桥梁
Ziqi Yu,Lifeng Zhang,Bo Jiang et al.
Ziqi Yu et al.
Fatty acids (FAs) are indispensable for cellular homeostasis and centered in anabolic and catabolic pathways that are tightly governed by long-chain acyl-CoA synthetases (ACSLs). These enzymes drive fatty acid β-oxidation (FAO) to generate...
Metabolic and immune dysfunction at the crossroads between type 1 diabetes and neurodegeneration [0.03%]
代谢和免疫功能障碍：1型糖尿病与神经退行性病变的交汇点
Francesca D&#x;Addio,Loredana Bucciarelli,Maria Elena Lunati et al.
Francesca D&#x;Addio et al.
A growing body of evidence suggests that neurogenerative disorders are increasingly common in individuals with type 1 diabetes (T1D) and should be considered part of the heterogeneous impairment of the nervous system linked to the T1D condi...
Liver cancer chronically exposed to palmitate acquires ferroptosis resistance via the downregulation of glutamine-driven hepcidin expression [0.03%]
长期接触棕榈酸的肝癌通过谷氨酰胺驱动的hepcidin表达下调获得铁死亡抵抗性
Dong-Ho Kim,Mi Kyung Kim,Daehoon Kim et al.
Dong-Ho Kim et al.
Background: Immune checkpoint blockade (ICB) has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy remains limited. Recent studies demonstrate that resistance to ferroptosis is a significant bar...
Vitor Ferreira,Miguel López
Vitor Ferreira
Guanghong Jia,William P Fay,Christos S Mantzoros et al.
Guanghong Jia et al.