Daily transient coating of the intestine leads to weight loss and improved glucose tolerance [0.03%]
肠道的每日瞬时涂层会导致体重减轻和葡萄糖耐受性提高
Tammy Lo,Yuhan Lee,Chung-Yi Tseng et al.
Tammy Lo et al.
Introduction: Roux-en-Y gastric bypass surgery (RYGB) has been shown to be the gold standard treatment for obesity associated type-2-diabetes (T2D), however many T2D patients do not qualify or are reluctant to proceed wit...
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure [0.03%]
三羧酸循环相关代谢产物与心房颤动和心力衰竭的风险关系研究
Mònica Bulló,Christopher Papandreou,Jesus García-Gavilán et al.
Mònica Bulló et al.
Background: Tricarboxylic acid (TCA) cycle deregulation may predispose to cardiovascular diseases, but the role of TCA cycle-related metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remain...
Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1 [0.03%]
通过靶向Runx1作用于miR-30b通道的棕色脂肪组织移植改善糖尿病肾病
Yudan Zhang,Yingying Cai,Hongbin Zhang et al.
Yudan Zhang et al.
Objective: Adipose tissue is a major source of circulating microRNAs (miRNAs) that can regulate target genes in distant organs. However, the role of brown adipose tissue (BAT) in diabetic kidney disease (DKD) is still unk...
CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice [0.03%]
CC趋化因子配体3缺乏通过调节肝脏巨噬细胞募集和M1 / M2状态来改善小鼠的饮食诱导性脂肪肝炎
Liang Xu,Yongping Chen,Mayumi Nagashimada et al.
Liang Xu et al.
Background and aims: The global prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing. Chemokines and their receptors have potential as therapeutic targets of NAFLD. We investigated the role of CC chemokine...
Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals [0.03%]
血清代谢物组学分析揭示轻度高胆红素血症的吉尔伯特综合征患者脂质分解代谢增加
Claudia A Hana,Lan V Tran,Christine Mölzer et al.
Claudia A Hana et al.
Background: The protective role of mildly elevated bilirubin against CVD and diabetes mellitus type 2 (DMT2) is associated with a favorable lipid phenotype. As the mechanistic understanding of this protection in humans re...
Body mass cycling and predictors of body mass regain and its impact on cardiometabolic health [0.03%]
体重波动及体重回升的预测因素及其对心血管健康的影响
Manuel A Cornejo,Rudy M Ortiz
Manuel A Cornejo
Caloric restriction (CR) is the first line intervention to reduce adiposity and total body mass (BM) to improve insulin resistance and ameliorate metabolic derangements. However, the lost adipose mass is difficult to maintain reduced in the...
Non-obese non-alcoholic fatty liver disease (NAFLD) in Asia: an international registry study [0.03%]
亚洲非肥胖非酒精性脂肪肝病（NAFLD）的国际登记研究
Eunice Xiang-Xuan Tan,Jonathan Wei-Jie Lee,Nur Halisah Jumat et al.
Eunice Xiang-Xuan Tan et al.
Background: A significant proportion of the non-alcoholic fatty liver disease (NAFLD) population is non-obese. Prior studies reporting the severity of NAFLD amongst non-obese patients were heterogenous. Our study, using d...
Mechanisms of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovary syndrome [0.03%]
十二指肠黏膜重构在胰岛素抵抗的多囊卵巢综合征女性中的作用机制
Vasha Kaur,Georgios K Dimitriadis,Belen Pérez-Pevida et al.
Vasha Kaur et al.
Background: Duodenal mucosal resurfacing (DMR) is a novel day-case endoscopic intervention which results in weight loss-independent reductions in HbA1c in patient with type 2 diabetes mellitus (T2DM). We hypothesized that...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2021 Dec:125:154908. DOI:10.1016/j.metabol.2021.154908 2021
Heart failure in diabetes [0.03%]
糖尿病患者的心力衰竭
Stanislovas S Jankauskas,Urna Kansakar,Fahimeh Varzideh et al.
Stanislovas S Jankauskas et al.
Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excur...
Epigenetic modification in alcohol use disorder and alcoholic cardiomyopathy: From pathophysiology to therapeutic opportunities [0.03%]
酒精使用障碍和酒精性心肌病的表观遗传修饰：从病理生理到治疗机会
Lin Wu,Yingmei Zhang,Jun Ren
Lin Wu
Alcohol consumption prompts detrimental psychological, pathophysiological and health issues, representing one of the major causes of death worldwide. Alcohol use disorder (AUD), which is characterized by compulsive alcohol intake and loss o...