Sodium/glucose cotransporter 2 (SGLT2) inhibitors improve cardiac function by reducing JunD expression in human diabetic hearts [0.03%]
钠/葡萄糖共转运蛋白2 (SGLT2)抑制剂通过减少人类糖尿病心脏中的JunD表达来改善心脏功能
Raffaele Marfella,Nunzia D&#x;Onofrio,Maria Consiglia Trotta et al.
Raffaele Marfella et al.
Background: The pathogenesis of experimental diabetic cardiomyopathy may involve the activator protein 1 (AP-1) member, JunD. Using non-diabetic heart transplant (HTX) in recipients with diabetes, we examined the effects ...
One-hundred year evolution of prandial insulin preparations: From animal pancreas extracts to rapid-acting analogs [0.03%]
餐时胰岛素制剂一百年的演变：从动物胰腺提取物到速效类似物
Geremia B Bolli,Francesca Porcellati,Paola Lucidi et al.
Geremia B Bolli et al.
The first insulin preparation injected in humans in 1922 was short-acting, extracted from animal pancreas, contaminated by impurities. Ever since the insulin extracted from animal pancreas has been continuously purified, until an unlimited ...
Xiaogang Chu,Raghavan Pillai Raju
Xiaogang Chu
More than a century after discovering NAD+, information is still evolving on the role of this molecule in health and diseases. The biological functions of NAD+ and NAD+ precursors encompass pathways in cellular energetics, inflammation, met...
Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease [0.03%]
非酒精性脂肪肝病的分子靶点及新兴药物干预见解
Chander K Negi,Pavel Babica,Lola Bajard et al.
Chander K Negi et al.
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide. With no Food and Drug Administration approved drugs, current treatment options include dietary restrictions and lifestyle modification. NAF...
Julio Rosenstock,Stefano Del Prato
Julio Rosenstock
Basal insulin treatment is indispensable for patients with type 1 diabetes and often required by many with type 2 diabetes. Incremental advances lengthening the duration of action of insulin analogs and reducing pharmacodynamic variability ...
Effect of oral contraceptives on energy balance in women: A review of current knowledge and potential cellular mechanisms [0.03%]
口服避孕药对女性能量平衡的影响：当前知识和潜在细胞机制的回顾
Lore Metz,Laurie Isacco,Leanne M Redman
Lore Metz
Body weight management is currently of major concern as the obesity epidemic is still a worldwide challenge. As women face more difficulties to lose weight than men, there is an urgent need to better understand the underlying reasons and me...
Renu A Kowluru,Ghulam Mohammad
Renu A Kowluru
Diabetes is now considered as a 'silent epidemic' that claims over four million lives every year, and the disease knows no socioeconomic boundaries. Despite extensive efforts by the National and International organizations, and cutting-edge...
Angiopoietin-like protein 8 (betatrophin) inhibits hepatic gluconeogenesis through PI3K/Akt signaling pathway in diabetic mice [0.03%]
血管生成素样蛋白8（betatrophin）通过PI3K/Akt信号通路抑制糖尿病小鼠的肝糖异生作用
Zhicong Zhao,Xia Deng,Jue Jia et al.
Zhicong Zhao et al.
Background & aims: Angiopoietin-like protein 8 (ANGPTL8) is a 198 amino-acid long, novel secreted protein that is mainly expressed in the liver and brown adipose tissues. At present, evidence supporting the involvement of...
Systematic review with meta-analysis of diagnostic test accuracy for COVID-19 by mass spectrometry [0.03%]
系统综述及Meta分析：基于质谱检测COVID-19的诊断测试准确性研究
Matt Spick,Holly M Lewis,Michael J Wilde et al.
Matt Spick et al.
Background: The global COVID-19 pandemic has led to extensive development in many fields, including the diagnosis of COVID-19 infection by mass spectrometry. The aim of this systematic review and meta-analysis was to asse...
Cardiorenal protection with SGLT2 inhibitors in patients with diabetes mellitus: from biomarkers to clinical outcomes in heart failure and diabetic kidney disease [0.03%]
SGLT2抑制剂对糖尿病患者的心肾保护作用：从心衰和糖尿病肾病的生物标志物到临床结局
Hongyan Liu,Vikas S Sridhar,Jacinthe Boulet et al.
Hongyan Liu et al.
Type 2 diabetes (T2D) is one of the most common causes of chronic kidney disease (CKD) and cardiovascular (CV) disease. Until recently, glycemic and BP control were the cornerstones for preventing progression of CKD and CV disease associate...