Lipoprotein (a)-mediated vascular calcification: population-based and in vitro studies [0.03%]
脂蛋白(a)介导的血管钙化：基于人群和体外研究
Jia Peng,Ming-Ming Liu,Hui-Hui Liu et al.
Jia Peng et al.
Background: Lipoprotein (a) [Lp(a)] is a causal risk factor for cardiovascular diseases, while its role in vascular calcification has not been well-established. Here, we investigated an association of Lp(a) with vascular ...
Deciphering metformin action in obese mice: A critical re-evaluation of established protocols [0.03%]
二甲双胍在肥胖小鼠中作用机制的解析——对传统实验方案的重新评估
Mairam Kaplanian,Cecile Philippe,Sameer Abu Eid et al.
Mairam Kaplanian et al.
Background and purpose: Despite extensive efforts and a plethora of suggested targets and pathways, the mechanism via which metformin lowers blood glucose remains obscure. Obstacles that hamper progress in understanding m...
Adiponectin promotes repair of renal tubular epithelial cells by regulating mitochondrial biogenesis and function [0.03%]
脂联素通过调节线粒体增殖和功能促进肾小管上皮细胞修复
Yinyin Chen,Yiya Yang,Zhiwen Liu et al.
Yinyin Chen et al.
Background: Mitochondrial biogenesis and dysfunction are associated with renal tubular epithelial cell injury and the pathophysiological development of diabetic nephropathy (DN). Adiponectin (APN) is a plasma hormone prot...
Dynamic assessment of insulin secretion and insulin resistance in Asians with prediabetes [0.03%]
动态评估亚洲前驱糖尿病患者胰岛素分泌和胰岛素抵抗状况
Faidon Magkos,Michelle H Lee,Maybritte Lim et al.
Faidon Magkos et al.
Aims/hypothesis: Prediabetes and type 2 diabetes are highly prevalent in Asia. Understanding the pathophysiology of abnormal glucose homeostasis in Asians will have important implications for reducing disease burden, but ...
Metabolic dysfunction-associated fatty liver disease and the risk of 24 specific cancers [0.03%]
代谢紊乱相关非酒精性脂肪肝与24种特定癌症风险的关系
Zhenqiu Liu,Chunqing Lin,Chen Suo et al.
Zhenqiu Liu et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant health issue closely associated with multiple metabolic dysfunctions. The association between MAFLD and cancer risk is yet unknown....
Julia Ware,Roman Hovorka
Julia Ware
Since the discovery of insulin 100 years ago, we have seen considerable advances across diabetes therapies. The more recent advent of glucose-responsive automated insulin delivery has started to revolutionise the management of type 1 diabet...
Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK [0.03%]
重组HDL- apoE3通过ID1及其下游激酶ERK1 / 2，AKT和p38 MAPK促进内皮细胞迁移
Eftaxia-Konstantina Valanti,Katerina Dalakoura-Karagkouni,Panagiotis Fotakis et al.
Eftaxia-Konstantina Valanti et al.
Introduction: Atherosclerotic Coronary Artery Disease (ASCAD) is the leading cause of mortality worldwide. Novel therapeutic approaches aiming to improve the atheroprotective functions of High Density Lipoprotein (HDL) in...
Pierpaolo Falcetta,Michele Aragona,Alessandra Bertolotto et al.
Pierpaolo Falcetta et al.
The discovery of insulin in 1921 - due to the efforts of the Canadian research team based in Toronto - has been a landmark achievement in the history of medicine. Lives of people with diabetes were changed forever, considering that in the p...
Corrigendum to 'Dietary carbohydrate intake and new-onset diabetes: A Nationwide Cohort Study in China' [Metab Clin Exp 123 (2021) 154865] [0.03%]
《饮食碳水化合物摄入量与新发糖尿病：中国全国队列研究》[代谢临床与实验123（2021）154865]的勘误表
Chun Zhou,Zhuxian Zhang,Mengyi Liu et al.
Chun Zhou et al.
Irene Caruso,Francesco Giorgino
Irene Caruso
Despite remarkable advances in diabetes care, patients with type 2 diabetes are still burdened by higher morbidity and mortality than non-diabetic individuals. Atherosclerotic cardiovascular disease, heart failure, and chronic kidney diseas...