Despina Sanoudou,Michael A Hill,Matthew J Belanger et al.
Despina Sanoudou et al.
Florencia Halperin,Teresa Mezza,Ping Li et al.
Florencia Halperin et al.
Aims: Insulin potentiates glucose-stimulated insulin secretion. These effects are attenuated in beta cell-specific insulin receptor knockout mice and insulin resistant humans. This investigation examines whether short dur...
Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism [0.03%]
牻牛儿牻牛儿基焦磷酸化酶RAB14调控甲羟戊酸途径通过乙酰辅酶A羧化酶α介导的AKT丝氨酸磷酸化来调节肝脏葡萄糖代谢
Lai Wang,Lijun Zhu,Zuguo Zheng et al.
Lai Wang et al.
Statin use accompanies with increased risk of new onset of type 2 diabetes, however, the underlying mechanisms remain not be fully understood and effective prevention strategies are still lacking. Herein, we find that both pharmacological a...
ABCC1 modulates negative feedback control of the hypothalamic-pituitary-adrenal axis in vivo in humans [0.03%]
ABCC1调节人活体下丘脑-垂体-肾上腺轴的负反馈控制
Catriona J Kyle,Mark Nixon,Natalie Z M Homer et al.
Catriona J Kyle et al.
Background: Cortisol and corticosterone both circulate in human plasma and, due to differing export by ATP-binding cassette (ABC) transporters, may exert differential cellular effects. ABCB1 (expressed in brain) exports c...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Mar:128:155118. DOI:10.1016/j.metabol.2021.155118 2022
High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy [0.03%]
术后高血浆和舌部尿鸟苷酸作为改变 Sleeve胃切除术患者食物偏好的潜在因素
Gema Frühbeck,Sara Becerril,Marina Martín et al.
Gema Frühbeck et al.
Background: The biological mediators supporting long-term weight loss and changes in dietary choice behaviour after sleeve gastrectomy remain unclear. Guanylin and uroguanylin are gut hormones involved in the regulation o...
João Pessoa,José Teixeira
João Pessoa
Background: Due to its extremely high prevalence and severity, non-alcoholic fatty liver disease (NALFD) is a serious health and economic concern worldwide. Developing effective methods of diagnosis and therapy demands a ...
PTC923 (sepiapterin) lowers elevated blood phenylalanine in subjects with phenylketonuria: a phase 2 randomized, multi-center, three-period crossover, open-label, active controlled, all-comers study [0.03%]
一项关于PTC923（蝶肽素）降低高苯丙酮尿症患者体内苯丙氨酸含量的II期多中心交叉对照开放性试验：对所有类型苯酮酸尿症患者均有效
Drago Bratkovic,Lali Margvelashvili,Michel C Tchan et al.
Drago Bratkovic et al.
Background & aim: PTC923 (formerly CNSA-001), an oral formulation of sepiapterin, a natural precursor of intracellular tetrahydrobiopterin (BH4), has been shown in humans to induce larger increases in circulating BH4 vs. ...
The clustering of Cardiovascular, Renal, Adipo-Metabolic Eye and Liver disease with type 2 diabetes [0.03%]
2型糖尿病患者的血管、肾脏、脂肪-代谢性眼病和肝病的聚集现象分析研究
M C Thomas
M C Thomas
Type 2 diabetes is associated with an increased risk of cardiovascular disease, heart failure, chronic kidney disease, fatty liver disease, eye and foot disease. But equally, these conditions are associated with an increased risk of type 2 ...
Among simple non-invasive scores, Pro-C3 and ADAPT best exclude advanced fibrosis in Asian patients with MAFLD [0.03%]
在简单无创评分中，Pro-C3和ADAPT排除亚洲MAFLD患者肝纤维化的价值最高
Liang-Jie Tang,Hong-Lei Ma,Mohammed Eslam et al.
Liang-Jie Tang et al.
Background: With metabolic dysfunction-associated fatty liver disease (MAFLD) incidence and prevalence increasing, it is necessary to identify patients with advanced fibrosis (F3-F4 stages). We evaluated the performance o...
Effect of antiresorptive therapy on aromatase inhibitor induced bone loss in postmenopausal women with early-stage breast cancer: A systematic review and meta-analysis of randomized controlled trials [0.03%]
抗吸收疗法对绝经后早期乳腺癌妇女促卵泡激素抑制剂致骨量减少影响的系统评价和meta分析
Aya Bassatne,Abir Bou Khalil,Marlene Chakhtoura et al.
Aya Bassatne et al.
Background: Aromatase inhibitors (AIs) are routinely used to treat postmenopausal women with early-stage breast cancer. Although AIs improve breast cancer outcomes, they increase the risk of osteoporosis and fractures. Th...