cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1 [0.03%]
cAMP应答元件结合蛋白通过靶向长链非编码RNA DLX6-AS1介导糖尿病肾病中的足细胞损伤
Wen Zheng,Jia Guo,Xiaoqing Lu et al.
Wen Zheng et al.
Background: Progressive proteinuria is one of the earliest clinical features of diabetic nephropathy (DN). In our previous study, lncRNA DLX6-AS1 (DLX6-AS1, Dlx6os1 in the mouse) was found to be associated with the extent...
Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons [0.03%]
G蛋白激酶2介导的促性腺激素释放激素神经元接吻肽作用抑制在营养剥夺与青春期抑制间的关联作用机制研究
Cecilia Perdices-Lopez,María S Avendaño,Alexia Barroso et al.
Cecilia Perdices-Lopez et al.
Background: Perturbations in the timing of puberty, with potential adverse consequences in later health, are increasingly common. The underlying neurohormonal mechanisms are unfolded, but nutritional alterations are key c...
Luke Norton,Chris Shannon,Amalia Gastaldelli et al.
Luke Norton et al.
Insulin is the master regulator of glucose, lipid, and protein metabolism. Following ingestion of an oral glucose load or mixed meal, the plasma glucose concentration rises, insulin secretion by the beta cells is stimulated and the hyperins...
Effects of intraduodenal infusion of lauric acid and L-tryptophan, alone and combined, on glucoregulatory hormones, gastric emptying and glycaemia in healthy men [0.03%]
十二指肠内单独或联合输注月桂酸和L-色氨酸对健康男性体内糖调节激素、胃排空和血糖的影响
M Hajishafiee,C McVeay,K Lange et al.
M Hajishafiee et al.
Background and aim: In healthy men, intraduodenal administration of the fatty acid, lauric acid ('C12') and the amino acid, L-tryptophan ('TRP'), at loads that individually do not affect energy intake, reduce energy intak...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Apr:129:155140. DOI:10.1016/j.metabol.2022.155140 2022
Bone morphogenic protein 9 is a novel thermogenic hepatokine secreted in response to cold exposure [0.03%]
骨形态生成蛋白9是一种新型的肝脏分泌热原蛋白，在寒冷暴露后分泌
Jee-Hyun Um,Shi-Young Park,Jang Ho Hur et al.
Jee-Hyun Um et al.
Objective: Maintaining a constant core body temperature is essential to homeothermic vertebrate survival. Adaptive thermogenesis in brown adipose tissue and skeletal muscle is the primary mechanism of adjustment to an ext...
The zebrafish model system for dyslipidemia and atherosclerosis research: Focus on environmental/exposome factors and genetic mechanisms [0.03%]
斑马鱼在血脂异常和动脉粥样硬化研究中的模型系统作用：重点关注环境/暴露组因素和遗传机制
Marina Vasyutina,Asiiat Alieva,Olga Reutova et al.
Marina Vasyutina et al.
Dyslipidemias and atherosclerosis play a pivotal role in cardiovascular risk and disease. Although some pathophysiological mechanisms underlying these conditions have been unveiled, several knowledge gaps still remain. Experimental models, ...
Effects of aerobic exercise on fibroblast growth factor 21 in overweight and obesity. A systematic review [0.03%]
有氧运动对超重和肥胖者fibroblast生长因子21的影响系统评价研究
María Porflitt-Rodríguez,Valentina Guzmán-Arriagada,Romina Sandoval-Valderrama et al.
María Porflitt-Rodríguez et al.
Fibroblast growth factor 21 (FGF21) has been suggested to improve metabolism during aerobic exercise in obesity. However, the variability of exercise interventions gives rise to discrepancies in the field. Therefore, we aimed to systematica...
Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes [0.03%]
体重和血糖波动与糖尿病患者髋部骨折风险的关系
Jeongmin Lee,Kyungdo Han,Sang Hyun Park et al.
Jeongmin Lee et al.
Background: Diabetes is associated with a high risk of fragility fracture. However, there are controversies regarding the effect of fluctuations in metabolic parameters on the risk of fracture. We aimed to investigate the...
The effect of dietary patterns on non-alcoholic fatty liver disease diagnosed by biopsy or magnetic resonance in adults: a systematic review of randomised controlled trials [0.03%]
饮食模式对成人非酒精性脂肪肝疾病的影响：系统评价和 meta 分析
Angeliki M Angelidi,Angeliki Papadaki,Eric Nolen-Doerr et al.
Angeliki M Angelidi et al.
Adhering to specific dietary patterns might hold promise as a lifestyle modification treatment of non-alcoholic fatty liver disease (NAFLD). The aim of this systematic review was to examine the effect of dietary patterns on changes in hepat...
Ismael González-García,Óscar Freire-Agulleiro,Naoki Nakaya et al.
Ismael González-García et al.
Background and aims: Olfactomedin 2 (OLFM2; also known as noelin 2) is a pleiotropic protein that plays a major role in olfaction and Olfm2 null mice exhibit reduced olfactory sensitivity, as well as abnormal motor coordi...