The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome [0.03%]
CCAAT/enhancer结合蛋白和淋巴细胞特异性蛋白与胰岛素信号转导分子CBL的相互作用在多囊卵巢综合征发病机制中起重要作用
Haoran Shen,Xiao Xu,Zhongpeng Fu et al.
Haoran Shen et al.
Background: Polycystic ovary syndrome (PCOS) is a hormonal disorder characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance. Evidence suggests that aberrations in insulin signaling-associated path...
Endothelial sodium channel activation mediates DOCA-salt-induced endothelial cell and arterial stiffening [0.03%]
血管紧张素激活介导DOCA盐诱导的内皮细胞和动脉僵硬现象
Liping Zhang,Yan Yang,Annayya R Aroor et al.
Liping Zhang et al.
Introduction: High salt intake and aldosterone are both associated with vascular stiffening in humans. However, our preliminary work showed that high dietary salt alone did not increase endothelial cell (EC) or vascular s...
Fibroblast growth factor 21: A "rheostat" for metabolic regulation? [0.03%]
fibroblast生长因子21：代谢调节的"调速器"?
Qin-Ying She,Jing-Fu Bao,Hui-Zhen Wang et al.
Qin-Ying She et al.
Fibroblast growth factor 21 is an evolutionarily conserved factor that plays multiple important roles in metabolic homeostasis. During the past two decades, extensive investigations have improved our understanding of its delicate metabolic ...
Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation [0.03%]
Sirt6去乙酰化Caveolin-1诱导自噬并延缓高糖刺激的LDL转胞吞作用和动脉粥样硬化形成
Ying Zhao,Xiong Jia,Xiaoyan Yang et al.
Ying Zhao et al.
Background: Atherosclerosis (AS) is the basis of diabetic macrovascular complications. The plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) and deposition under the endothelium is...
Rationale for different formulations of omega-3 fatty acids leading to differences in residual cardiovascular risk reduction [0.03%]
不同ω-3脂肪酸配方其残余心血管风险降低作用差异的机制分析
R Preston Mason,Samuel C R Sherratt,Robert H Eckel
R Preston Mason
Chronic circadian disruption on a high-fat diet impairs glucose tolerance [0.03%]
慢性高脂饮食下的昼夜节律紊乱会损害葡萄糖耐量
Kirsi-Marja Zitting,Ramalingam Vetrivelan,Robin K Yuan et al.
Kirsi-Marja Zitting et al.
Background: Nearly 14% of Americans experience chronic circadian disruption due to shift work, increasing their risk of obesity, diabetes, and other cardiometabolic disorders. These disorders are also exacerbated by moder...
REEP6 knockout leads to defective β-adrenergic signaling in adipocytes and promotes obesity-related metabolic dysfunction [0.03%]
REEP6敲除导致脂肪细胞β肾上腺素能信号缺陷并促进肥胖相关代谢紊乱
Yeonho Son,Cheoljun Choi,Abhirup Saha et al.
Yeonho Son et al.
Introduction: The mobilization and catabolism of lipid energy is a central function of adipocytes that is under the control of the β-adrenergic signaling pathway, and defects in β-adrenergic signaling in adipocytes have...
Metformin and the heart: Update on mechanisms of cardiovascular protection with special reference to comorbid type 2 diabetes and heart failure [0.03%]
二甲双胍与心脏：心肾保护机制的最新研究（尤其是2型糖尿病和心力衰竭合并症中的作用）更新
Guntram Schernthaner,Kerstin Brand,Clifford J Bailey
Guntram Schernthaner
Metformin has been in clinical use for the management of type 2 diabetes for more than 60 years and is supported by a vast database of clinical experience: this includes evidence for cardioprotection from randomised trials and real-world st...
Methods paper: Performance characteristics of novel assays for circulating levels of proglucagon-derived peptides and validation in a placebo controlled cross-over randomized clinical trial [0.03%]
方法学论文：新型胰高糖素衍生成肽循环水平测定方法的性能特征及其在安慰剂对照交叉随机临床试验中的验证研究
Nikolaos Perakakis,Bhanu Kalra,Angeliki M Angelidi et al.
Nikolaos Perakakis et al.
Background: The measurement of proglucagon-derived peptides (PGDPs) is a challenging task mainly due to major overlaps in their molecular sequence in addition to their low circulating levels. Here, we present the technica...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Apr:129:155157. DOI:10.1016/j.metabol.2022.155157 2022
Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patients [0.03%]
肥胖和2型糖尿病与住院COVID-19患者的研究
Hui-Qi Qu,Jingchun Qu,Joseph Glessner et al.
Hui-Qi Qu et al.
Background: Both obesity and type 2 diabetes (T2D) are reported to be highly enriched in hospitalized COVID-19 patients. Due to the close correlation between obesity and T2D, it is important to examine whether obesity and...