Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients [0.03%]
机器学习和半目标脂质组学识别住院COVID-19阳性患者和阴性患者的独特血清脂质标志物
Helena Castañé,Simona Iftimie,Gerard Baiges-Gaya et al.
Helena Castañé et al.
Background: Lipids are involved in the interaction between viral infection and the host metabolic and immunological responses. Several studies comparing the lipidome of COVID-19-positive hospitalized patients vs. healthy ...
Preadmission use of antidiabetic medications and mortality among patients with COVID-19 having type 2 diabetes: A meta-analysis [0.03%]
COVID-19合并2型糖尿病患者的入院前使用降糖药物与死亡率的关联：一项系统综述和.meta.分析
Nam Nhat Nguyen,Dung Si Ho,Hung Song Nguyen et al.
Nam Nhat Nguyen et al.
Background: Diabetes is an independent predictor of poor outcomes in patients with COVID-19. We compared the effects of the preadmission use of antidiabetic medications on the in-hospital mortality of patients with COVID-...
Lan Yao,Xianhui Liang,Yingjin Qiao et al.
Lan Yao et al.
Diabetic kidney disease (DKD) is a devastating microvascular complication associated with diabetes mellitus. Recently, the major focus of glomerular lesions of DKD has partly shifted to diabetic tubulopathy because of renal insufficiency an...
Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming [0.03%]
急性肾损伤转为慢性肾脏病：代谢重组的作用
Zijing Zhu,Jijia Hu,Zhaowei Chen et al.
Zijing Zhu et al.
Acute kidney injury (AKI) is a global public health concern associated with high morbidity and mortality. Although advances in medical management have improved the in-hospital mortality of severe AKI patients, the renal prognosis for AKI pa...
Sterol carrier protein 2 in lipid metabolism and non-alcoholic fatty liver disease: Pathophysiology, molecular biology, and potential clinical implications [0.03%]
卵磷脂胆固醇酰基转移酶在脂代谢和非酒精性脂肪肝病中的作用：病理生理学、分子生物学及潜在的临床意义
Can Xu,Heng Li,Chao-Ke Tang
Can Xu
Non-alcoholic fatty liver disease (NAFLD) is considered as the most common chronic liver disease and has become a rapidly global public health problem. Sterol carrier protein 2 (SCP-2), also called non-specific lipid-transfer protein, is pr...
Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity [0.03%]
肺部表面活性物质中减少的DMPC和PMPC促进肥胖中的SARS-CoV-2感染
Kang Du,Ling Sun,Zichen Luo et al.
Kang Du et al.
Objective: Obesity is an established risk factor for higher SARS-CoV-2 viral loads, severe COVID-19 pneumonia requiring hospitalization, and worse outcomes. However, the underlying mechanisms for the increased risk are no...
Corrigendum to 'Targeting mammalian serine/threonine-protein kinase 4 through yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis [Metabolism Clinical and Experimental 108 (2020) 154258] [0.03%]
“靶向酪氨酸激酶YAP/TEAD介导的上皮间质转化通过作用于哺乳动物KKL-4减轻糖尿病肾小球硬化[代谢临床和实验第108期(2020)154258]勘误
Tingting Yang,Cai Heng,Yi Zhou et al.
Tingting Yang et al.
Towards harnessing the value of organokine crosstalk to predict the risk for cardiovascular disease in non-alcoholic fatty liver disease [0.03%]
利用器官细胞因子互作预测非酒精性脂肪肝患者心血管疾病发病风险的研究进展
Theodor Baars,Robert K Gieseler,Polykarpos C Patsalis et al.
Theodor Baars et al.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Importantly, NAFLD increases the risk for cardiovascular disease (CVD). A causal relationship has been substantiated. Given the pandemic proportions of NAFL...
Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice [0.03%]
八周有氧运动可为小鼠在代谢压力下提供肝脏和心血管元凶健康及脂肪组织重塑方面的保护作用：一项关于小鼠的研究
Youn Ju Kim,Hye Jin Kim,Sang Gyu Lee et al.
Youn Ju Kim et al.
Background: The relationship between exercise training and health benefits is under thorough investigation. However, the effects of exercise training on the maintenance of metabolic health are unclear. ...
Ras guanine nucleotide-releasing protein-4 promotes renal inflammatory injury in type 2 diabetes mellitus [0.03%]
Ras鸟苷酸释放蛋白-4促进2型糖尿病肾炎损伤作用及其机制研究
Shuai Huang,Junmei Wang,Li Zhang et al.
Shuai Huang et al.
Introduction: Ras guanine nucleotide-releasing protein-4 (RasGRP4) is an activator of Ras protein, which plays significant roles in both the inflammatory response and immune activation. This study determined the role of R...