Cardiorespiratory fitness, genetic susceptibility, inflammation and risk of incident type 2 diabetes: A population-based longitudinal study [0.03%]
有氧运动能力、遗传易感性、炎症与2型糖尿病发病风险——一项基于人群的纵向研究
Chenjie Xu,Yabing Hou,Keyi Si et al.
Chenjie Xu et al.
Objective: To examine whether the association between cardiorespiratory fitness (CRF) and type 2 diabetes (T2D) is modified by genetic susceptibility and inflammation. ...
A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on [0.03%]
2022年肥胖流行病学的更新及行动呼吁：随着其孪生COVID-19大流行似乎正在消退，肥胖和代谢紊乱的大流行仍在继续
Chrysoula Boutari,Christos S Mantzoros
Chrysoula Boutari
The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe, stating that 60% of citizens in the area of Europe are either overweight or obese, and highlighting the implications of the obesity pandemic, especia...
Increased plasma fatty acid clearance, not fatty acid concentration, is associated with muscle insulin resistance in people with obesity [0.03%]
肥胖人群的血浆脂肪酸清除率增加而非脂肪酸浓度与肌肉胰岛素抵抗有关
Chao Cao,Han-Chow E Koh,Stephan Van Vliet et al.
Chao Cao et al.
Background: Although it is well-accepted that increased plasma free fatty acid (FFA) concentration causes lipid overload and muscle insulin resistance in people with obesity, plasma FFA concentration poorly predicts insul...
Glycerol's contribution to lactate production outside of a glucose intermediate in fasting humans [0.03%]
甘油直接转化为乳酸而不是通过葡萄糖中间产物在禁食的人体中的贡献
Ankit Shah,Yujue Wang,Xiaoyang Su et al.
Ankit Shah et al.
Background: Glycerol is a well-recognized substrate for new glucose production via gluconeogenesis in the liver. However, its carbon contribution to the glycolytic intermediate lactate is not known in humans. ...
Effects of statins on specialized pro-resolving mediators: An additional pathway leading to resolution of inflammation [0.03%]
他汀类药物对专业解决介质的影响：促进炎症消退的额外途径
Shabnam Radbakhsh,Niki Katsiki,Raul D Santos et al.
Shabnam Radbakhsh et al.
Statins are a class of cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Anti-inflammatory and antioxidant properties, as well as improvement of endothelial function and plaque stabilization ...
Vascular smooth muscle cell c-Fos is critical for foam cell formation and atherosclerosis [0.03%]
血管平滑肌细胞c-Fos在泡沫细胞形成和动脉粥样硬化中起关键作用
Guolin Miao,Xi Zhao,Siu-Lung Chan et al.
Guolin Miao et al.
Background: Hyperlipidemia-induced vascular smooth muscle cell (VSMC)-derived foam cell formation is considered a crucial event in the development of atherosclerosis. Since c-Fos emerges as a key modulator of lipid metabo...
Metabolic obesity phenotypes: a friend or foe of digestive polyps?-An observational study based on National Inpatient Database [0.03%]
代谢性肥胖表型：消化息肉的朋友还是敌人？基于全国住院病人数据库的观察研究
Yiping Cheng,Junming Han,Qihang Li et al.
Yiping Cheng et al.
Objective: Obesity is associated with an increased risk of digestive polyps, whereas all obesity are not created equally. The role of metabolic states in occurrence risks of polyps among individuals with varying degrees o...
Observational Study
Metabolism: clinical and experimental. 2022 Jul:132:155201. DOI:10.1016/j.metabol.2022.155201 2022
Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway [0.03%]
五味子乙素通过AMPK/mTOR信号诱导自噬促进脂肪酸氧化改善肝脏脂质蓄积作用研究
Li-Shan Yan,Shuo-Feng Zhang,Gan Luo et al.
Li-Shan Yan et al.
Background: Schisandrin B (Sch B), which inhibits hepatic steatosis caused by non-alcoholic fatty liver disease (NAFLD), is one of the most active dibenzocyclooctadienes isolated from Schisandra chinensis (Turcz.) Baill w...
Effects of ileal glucose infusion on enteropancreatic hormone secretion in humans: relationship to glucose absorption [0.03%]
肠腔内葡萄糖输注对人类肠胰激素分泌的影响及与葡萄糖吸收的关系
Xiang Zhang,Zhiqiang Cheng,Shuohui Dong et al.
Xiang Zhang et al.
Backgrounds: The distal small intestine plays an important role in regulating the secretion of entero-pancreatic hormones that are critical to the control of glucose metabolism and appetite, but the quantitative contribut...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Jun:131:155198. DOI:10.1016/j.metabol.2022.155198 2022
Prandial hepatic glucose production during hypoglycemia is altered after gastric bypass surgery and sleeve gastrectomy [0.03%]
胃旁路手术和袖状胃切除术后，在低血糖期间餐时肝糖产生发生变化
Marzieh Salehi,Amalia Gastaldelli,Ralph DeFronzo
Marzieh Salehi
Aims/hypothesis: Roux-en Y gastric bypass surgery (GB) and sleeve gastrectomy (SG) alter prandial glucose metabolism, producing lower nadir glucose values and predisposing susceptible individuals to prandial hypoglycemia....