Use of the new guidelines on an earlier age threshold of 35 years for diabetes screening can identify an additional 6.3 million undiagnosed individuals with diabetes and 72.3 million individuals with prediabetes among Chinese adults: An analysis of a nationally representative survey [0.03%]
在中国成人中应用新指南较低年龄（35岁）的糖尿病筛查界值可额外识别出630万未诊断糖尿病患者和7230万糖尿病前期患者：一项具有全国代表性的调查分析
Qiuyu Cao,Ruizhi Zheng,Ruixin He et al.
Qiuyu Cao et al.
Background: Young-onset diabetes has been increasingly prevalent in China and most of the young patients with diabetes remain undiagnosed. Recently, the American Diabetes Association (ADA) updated their screening criteria...
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 [0.03%]
SARS-CoV-2感染通过IRF1损害肺、肝、脂肪组织和胰腺细胞中的胰岛素/IGF信号通路
Jihoon Shin,Shinichiro Toyoda,Shigeki Nishitani et al.
Jihoon Shin et al.
Background: COVID-19 can cause multiple organ damages as well as metabolic abnormalities such as hyperglycemia, insulin resistance, and new onset of diabetes. The insulin/IGF signaling pathway plays an important role in r...
TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia/reperfusion injury [0.03%]
线粒体动态平衡在心脏缺血再灌注损伤中的作用机制研究
Shiqun Sun,Wenjun Yu,Haixia Xu et al.
Shiqun Sun et al.
Objective: Mitochondria are essential for myocardial ischemia/reperfusion (I/R) injury. TBC domain family member 15 (TBC1D15) participates in the regulation of mitochondrial homeostasis although its role remains elusive i...
GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease [0.03%]
GW9662，一种过氧化物酶体增殖活化受体γ拮抗剂，可抑制非酒精性脂肪肝病的发展
Anja Baumann,Katharina Burger,Annette Brandt et al.
Anja Baumann et al.
Background and aims: Insulin resistance is among the key risk factors for the development of non-alcoholic fatty liver disease (NAFLD). Recently, it has been reported that GW9662, shown to be a potent peroxisome prolifera...
COVID-19 and sulfonylureas: A reminder of the pleiotropic actions of an old class of drugs just before their swansong [0.03%]
新冠肺炎与磺脲类药物：一种老药多效作用的提醒，在其谢幕之前
Theocharis Koufakis,Djordje S Popovic,Symeon Metallidis et al.
Theocharis Koufakis et al.
Chris R Triggle,Ibrahim Mohammed,Khalifa Bshesh et al.
Chris R Triggle et al.
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the first-choice drug used daily by approximately 150 million people. An accumulation of positive pre-clinical and clinical data has stimulated interest...
Association of fatty liver index with all-cause and disease-specific mortality: A nationwide cohort study [0.03%]
脂肪肝指数与全因及特定病因死亡率的关系：全国队列研究
Goh Eun Chung,Su-Min Jeong,Eun Ju Cho et al.
Goh Eun Chung et al.
Background: Population-based data regarding the prognostic implications of hepatic steatosis have been inconsistent. We examined the association between the fatty liver index (FLI) with all-cause and disease-specific mort...
Nonalcoholic fatty liver disease and cardiovascular diseases: A Mendelian randomization study [0.03%]
非酒精性脂肪肝病与心血管疾病的相关性：一项孟德尔随机化研究
Hexiang Peng,Siyue Wang,Mengying Wang et al.
Hexiang Peng et al.
Background: Evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with cardiovascular diseases (CVDs). However, the results are inconsistent, and the causality remains to be established. ...
Despina Sanoudou,Kalliopi K Gkouskou,Aristides G Eliopoulos et al.
Despina Sanoudou et al.
Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy [0.03%]
金属蛋白酶PAPP-A活性增强可促进糖尿病引起的肾小球肥大
Malene R Jepsen,Jakob A Østergaard,Cheryl A Conover et al.
Malene R Jepsen et al.
Background: Diabetic nephropathy (DN) is a serious complication of diabetes and a common cause of end stage renal failure. Insulin-like growth factor (IGF)-signaling has been implicated in DN, but is mechanistically poorl...