The continuum of insulin development viewed in the context of a collaborative process toward leveraging science to save lives: Following the trail of publications and patents one century after insulin's first use in humans [0.03%]
合作促进科学进步进而拯救生命的进程视角下的胰岛素研发百年连续谱：胰岛素首次用于人类之后的科研论文和专利动向追踪
Antea DeMarsilis,Christos S Mantzoros
Antea DeMarsilis
Nearly 100 years ago, diabetes, a disease expected to reach global prevalence of at least 10% within the decade, was a fatal diagnosis. This year of 2022 marks a century since insulin, a lifesaving treatment for those living with diabetes, ...
Time to transition from a negative nomenclature describing what NAFLD is not, to a novel, pathophysiology-based, umbrella classification of fatty liver disease (FLD) [0.03%]
从描述NAFLD“不是什么”的消极命名法转向基于病理生理学的脂肪肝病（FLD）的新分类体系的时候了
Laura Valenzuela-Vallejo,Christos S Mantzoros
Laura Valenzuela-Vallejo
Non-alcoholic fatty liver disease (NAFLD) is a definition of a prevalent condition that has been given a name describing what the disease is not, mainly due to gaps in the physiopathological understanding of NAFLD when the name was given to...
Compromised glycolysis contributes to foot process fusion of podocytes in diabetic kidney disease: Role of ornithine catabolism [0.03%]
受损糖酵解参与糖尿病肾病足细胞突触小带融合：鸟氨酸分解代谢的作用
Qiang Luo,Wei Liang,Zongwei Zhang et al.
Qiang Luo et al.
Introduction: Compromised glycolysis in podocytes contributes to the initiation of diabetic kidney disease (DKD). Podocyte injury is characterized by cytoskeletal remodeling and foot process fusion. Compromised glycolysis...
Serine active site containing protein 1 depletion alters lipid metabolism and protects against high fat diet-induced obesity in mice [0.03%]
丝氨酸活性位点含蛋白1缺乏通过改变脂质代谢来抵抗高脂饮食诱导的小鼠肥胖现象
Miaomiao Du,Xueyun Li,Fangyi Xiao et al.
Miaomiao Du et al.
Objective: Although the serine active site containing 1 (SERAC1) protein is essential for cardiolipin remodeling and cholesterol transfer, its physiological role in whole-body energy metabolism remains unclear. Thus, we i...
Lipid-induced glucose intolerance is driven by impaired glucose kinetics and insulin metabolism in healthy individuals [0.03%]
脂质诱导的健康人的葡萄糖耐受不良由葡萄糖动力学和胰岛素代谢障碍驱动
Domenico Tricò,Alessandro Mengozzi,Simona Baldi et al.
Domenico Tricò et al.
Aims: Hypertriglyceridemia is associated with an increased risk of type 2 diabetes. We aimed to comprehensively examine the effects of hypertriglyceridemia on major glucose homeostatic mechanisms involved in diabetes prog...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Sep:134:155247. DOI:10.1016/j.metabol.2022.155247 2022
n-3 PUFA dietary lipid replacement normalizes muscle mitochondrial function and oxidative stress through enhanced tissue mitophagy and protects from muscle wasting in experimental kidney disease [0.03%]
膳食n-3多不饱和脂肪酸替代通过增强组织线粒体自噬可改善肾脏疾病模型中的肌肉线粒体功能和氧化应激并防止肌肉减少症
Gianluca Gortan Cappellari,Annamaria Semolic,Giulia Ruozi et al.
Gianluca Gortan Cappellari et al.
Introduction and methods: Skeletal muscle mitochondrial dysfunction may cause tissue oxidative stress and consequent catabolism in chronic kidney disease (CKD), contributing to patient mortality. We investigated in 5/6-ne...
Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice [0.03%]
Higd1a促进运动介导的饮食诱导的肥胖小鼠脂肪肝缓解
Jie-Ying Zhu,Min Chen,Wang-Jing Mu et al.
Jie-Ying Zhu et al.
Background: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common liver disease. Exercise is an effective strategy against NAFLD, but its underlying molecular mechanism is not completely understood. ...
SGLT2-inhibitors reduce the cardiac autonomic neuropathy dysfunction and vaso-vagal syncope recurrence in patients with type 2 diabetes mellitus: the SCAN study [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂可减少2型糖尿病心脏自主神经病功能障碍及血管迷走性晕厥复发：SCAN研究
Celestino Sardu,M Massimo Massetti,Pietro Rambaldi et al.
Celestino Sardu et al.
Background: In patients with type 2 diabetes mellitus (T2DM) the vaso-vagal syncope (VVS) recurrence could be due to the alteration of autonomic system function, evaluated by heart rate variability (HRV), and by 123I-meta...
Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity [0.03%]
利拉鲁肽或洛尔卡塞林治疗诱导的肥胖症患者的体重减轻不会改变循环中的总GDF-15和完整GDF-15水平
Laura Valenzuela-Vallejo,Pavlina Chrysafi,Jenny Bello-Ramos et al.
Laura Valenzuela-Vallejo et al.
Background: Growth differentiation factor 15 (GDF-15) is a stress-response cytokine proposed to be associated with body weight regulation. Aims: ...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Aug:133:155237. DOI:10.1016/j.metabol.2022.155237 2022
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes [0.03%]
TCF7L2在人类脂肪前体生物学中发挥复杂的作用或可促进2型糖尿病的遗传易感性
Manu Verma,Nellie Y Loh,Rugivan Sabaratnam et al.
Manu Verma et al.
Introduction: Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in ad...