Overview of methods that determine mitochondrial function in human disease [0.03%]
测定人类疾病中线粒体功能的方法概述
Eashan Sharma,Leila Fotooh Abadi,John Arnaud Kombe Kombe et al.
Eashan Sharma et al.
Cellular metabolism has a key role in the pathogenesis of human disease. Mitochondria are the organelles that generate most of the energy needed for a cell to function and drive cellular metabolism. Understanding the link between metabolic ...
Chemical discovery of a novel MD2/ADAM17 dual-target inhibitor as a potential therapeutic candidate for saturated fatty acid-induced myocardial inflammatory injury [0.03%]
化学发现新型MD2/ADAM17双靶点抑制剂作为治疗饱和脂肪酸致心肌炎性损伤潜在药物候选物
Xiao-Dan Zhang,Yun-Shan Zhong,Hao Yan et al.
Xiao-Dan Zhang et al.
Background and aims: While the therapeutic promise of anti-inflammatory interventions for obesity-associated cardiomyopathy is well recognized, clinically effective targeted therapies remain to be developed. Here, through...
Use of finerenone in patients with chronic kidney disease at high risk of heart failure [0.03%]
慢性肾病且有心力衰竭高风险患者的菲尼罗利用药情况
John P Hakim,Yehuda Handelsman,Trina Banerjee
John P Hakim
Treatment of symptomatic/advanced heart failure (HF) in patients who also have chronic kidney disease (CKD) and type 2 diabetes (T2D) may include a steroidal mineralocorticoid receptor antagonist (MRA). However, patients with CKD and T2D wh...
Evaluation of tetrahydropyridazine-based peripherally restricted dual inhibitors of CB1R and inducible nitric oxide synthase (iNOS) for treating metabolic syndrome disorders [0.03%]
基于四氢吡啶并氮杂卓的外周限制性CB1R和诱导型一氧化氮合成酶(iNOS)双靶点抑制剂治疗代谢综合征疾病的评价研究
Pinaki Bhattacharjee,Szabolcs Dvorácskó,Océane Pointeau et al.
Pinaki Bhattacharjee et al.
Background and purpose: The endocannabinoid system is a key regulator of metabolism, sparking interest in cannabinoid type 1 receptor (CB1R) antagonists as potential treatments for obesity and related conditions collectiv...
Non-invasive diagnosis and prognosis of MASH with fibrosis F2-F3: In need for a tailored, accessible, and affordable solution for the 21st century public health epidemic [0.03%]
非侵入性诊断和预测MASH合并F2-F3期纤维化：亟需针对二十一世纪公共健康流行病的定制、可及且可负担的解决方案
Konstantinos Stefanakis,Jacob George,Christos S Mantzoros
Konstantinos Stefanakis
Reconsidering the role of active vitamin D in preventing sarcopenia: Letter to the editor [0.03%]
重新考虑活性维生素D在预防肌少症方面的角色：写给编辑部的信件
Xinxin Luo,Juntong Liu,Li Wang
Xinxin Luo
Targeting RBP4-STRA6 retinol signaling disrupts adipose-prostate crosstalk: A novel strategy to suppress basal cell plasticity in androgen deprivation [0.03%]
靶向RBP4-STRA6视黄醇信号传导可破坏脂肪组织-前列腺相互作用：一种抑制雄激素剥夺的基底细胞塑性的新策略
Huan Xu,Dajun Gao,Yanting Shen et al.
Huan Xu et al.
Metabolic rewiring is a starter for lineage plasticity, which is an important driver of prostate development, tumorigenesis and treatment resistance. Androgen-targeted therapies are central to prostate cancer (PCa) management, yet the mecha...
Tetsuya Kawahara,Tetsuya Inazu,Gen Suzuki
Tetsuya Kawahara
Lactylation as a metabolic epigenetic modification: Mechanistic insights and regulatory pathways from cells to organs and diseases [0.03%]
乳酰化作为代谢表观遗传修饰：从细胞到器官和疾病的机制见解与调控途径
Cong Chen,Jie Wang,Xueying Zhu et al.
Cong Chen et al.
In recent years, lactylation, a novel post-translational modification, has demonstrated a unique role in bridging cellular metabolism and epigenetic regulation. This modification exerts a dual-edged effect in both cancer and non-cancer dise...
Comprehensive assessment of the causal effects and metabolite mediators of glucose-lowering drug targets on cardio-renal-liver-metabolic health [0.03%]
降糖药物靶点的因果效应及代谢介导物对心肾肝代谢健康影响的全面评估
Haozhang Huang,Huangtao Ruan,Xiaozhao Lu et al.
Haozhang Huang et al.
Aims: To investigate the relationship between glucose-lowering medications and cardio-renal-liver-metabolic (CRLM) health. Methods: Two...