Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications [0.03%]
整合功能基因组学和精细定位识别多变量肥胖遗传相关研究及其心血管代谢意义的调控机制
Suijian Wang,Sihua Liu,Hongqiang Zhang et al.
Suijian Wang et al.
Background: Obesity is a systemic disorder with heterogeneous fat distribution and complex metabolic complications. Conventional genome-wide association studies (GWAS) typically analyze individual obesity-related traits s...
Emerging incretin- and multi-agonist-based treatments - the continued refinement and continuous expansion of a potent therapeutic armamentarium for cardio-kidney-liver-metabolic diseases and beyond [0.03%]
新兴的肠降血糖素和多靶点激动剂治疗——心血管肾脏肝脏代谢性疾病的精确诊疗和持续扩展疗法
Emir Muzurović,Niki Katsiki,Špela Volčanšek et al.
Emir Muzurović et al.
While the use of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) has achieved a central position in our therapeutic armamentarium, new and innovative incretin- and multi-agonist-based treatment strategies hold further promise as pot...
Multi-omics profiling reveals CKM syndrome severity as a gradient risk factor for cancer: A prospective cohort study [0.03%]
多组学谱型揭示CKM综合征的严重性是一种癌症渐进展风险因素：前瞻性队列研究
Yu Huang,Yiwei Zhang,Yanjun Zhang et al.
Yu Huang et al.
Objective: Cardiovascular-Kidney-Metabolic (CKM) syndrome, a multisystem disorder, has been linked to cardiovascular and metabolic morbidity, but its association with cancer risk remains poorly characterized. This study a...
Personalizing bariatric metabolic surgery: Predictors of weight-loss success and risk of weight recurrence [0.03%]
代谢减重手术的个性化预测及术后体重回升的风险因素分析模型
Simona Panunzi,Sara Russo,Marcello Pompa et al.
Simona Panunzi et al.
Background: Bariatric metabolic surgery (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]) effectively treats obesity and type 2 diabetes; however, weight loss varies, necessitating predictive factors. ...
Bone inflammation in postmenopausal women with type 2 diabetes or obesity in relation to Wnt signaling and bone strength [0.03%]
绝经后女性骨炎与2型糖尿病或肥胖的关系以及Wnt信号传导和骨强度之间的关系
Giulia Leanza,Malak Faraj,Francesca Cannata et al.
Giulia Leanza et al.
Background and aim: Type 2 diabetes (T2D) and obesity (OB) are associated with chronic inflammation and increased fracture risk. We aimed to study the impact of inflammation and Wnt pathway regulation on bone health in su...
Global glucagon-like peptide-2 receptor activation linked to increased obesity risk in the UK Biobank [0.03%]
英国生物银行全球糖肠肽-2受体激活与肥胖风险增加有关
Peter A Gerlach,Sarina Gadgaard,Jakob S Madsen et al.
Peter A Gerlach et al.
Objective: The glucagon-like peptide-2 receptor (GLP-2R) is recognized as a potential target for the treatment of obesity and type 2 diabetes (T2D). Yet, the impact and mechanism of GLP-2R activation on these metabolic tr...
Proteomic effects of short-term liraglutide vs. placebo in a blinded crossover RCT: Implications for efficacy, safety, and comparison with semaglutide [0.03%]
利拉鲁肽短期 blinded 横断面随机对照试验的蛋白质组效应：对疗效、安全性与索马鲁肽比较的影响
Konstantinos Stefanakis,Valeria Gutierrez de Piñeres,Preethi Veeragandham et al.
Konstantinos Stefanakis et al.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert cardiometabolic benefits beyond weight loss, yet their systemic proteomic mechanisms remain incompletely defined. We profiled short-term liraglutide-i...
Essential role of endothelial T-cadherin in the transcytosis of circulating high-molecular-weight adiponectin to sub-vascular tissues [0.03%]
内皮T-钙黏着蛋白介导循环高分子量脂联素向血管周围组织转胞吞的作用机制研究
Shunsuke Shiode,Yuya Fujishima,Keita Fukuoka et al.
Shunsuke Shiode et al.
Background: Adiponectin, an adipocyte-derived protein, has diverse organ-protective effects, which are associated with its accumulation in vascular endothelial cells (VECs) as well as in various extravascular cell types, ...
Incretin-based therapy and atrial fibrillation risk in overweight or obesity [0.03%]
以血糖调节肽为靶点的治疗与超重或肥胖患者的房颤风险
Paschalis Karakasis,Konstantinos Vlachos,Nikolaos Fragakis et al.
Paschalis Karakasis et al.
Are GLP-1 receptor agonists associated with reduced atrial fibrillation risk? Analyzing data duplication and uncertainty [0.03%]
GLP-1受体激动剂与房颤风险降低有关吗？分析数据重复和不确定性
Lucas M Barbosa,Vinícius Martins Rodrigues Oliveira
Lucas M Barbosa