S100a16 deficiency prevents hepatic stellate cells activation and liver fibrosis via inhibiting CXCR4 expression [0.03%]
S100A16通过抑制CXCR4表达防止肝星状细胞活化和肝纤维化
Wen-Song Zhang,Rihua Zhang,Yaoqi Ge et al.
Wen-Song Zhang et al.
Introduction: Liver fibrosis caused by hepatic stellate cells (HSCs) activation is implicated in the pathogenesis of liver diseases. To date, there has been no effective intervention means for this process. S100 proteins ...
Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial [0.03%]
运动时间通过随机交叉对照试验影响2型糖尿病患者多组织代谢组和骨骼肌蛋白质组特征
Mladen Savikj,Ben Stocks,Shogo Sato et al.
Mladen Savikj et al.
Aims/hypothesis: Metabolic effects of exercise may partly depend on the time-of-day when exercise is performed. We tested the hypothesis that exercise timing affects the adaptations in multi-tissue metabolome and skeletal...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Oct:135:155268. DOI:10.1016/j.metabol.2022.155268 2022
Cross-talk between SARS-CoV-2 infection and the insulin/IGF signaling pathway: Implications for metabolic diseases in COVID-19 and for post-acute sequelae of SARS-CoV-2 infection [0.03%]
SARS-CoV-2感染与胰岛素/IGF信号通路的相互作用：对COVID-19代谢疾病和新冠肺炎后遗症的影响
Theodoros Kelesidis,Christos S Mantzoros
Theodoros Kelesidis
Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice [0.03%]
血红素P450氧化酶2J抑制可抑制小鼠的脉络膜新生血管生成
Yan Gong,Yohei Tomita,Matthew L Edin et al.
Yan Gong et al.
Introduction: Choroidal neovascularization (CNV) in age-related macular degeneration (AMD) leads to blindness. It has been widely reported that increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) diet...
Metabolic effects of truncal vagotomy when combined with bariatric-metabolic surgery [0.03%]
迷走神经切断术与代谢手术联合应用的代谢效应
Athena N Kapralou,George P Chrousos
Athena N Kapralou
Bariatric-metabolic surgery (BMS) in patients with obesity frequently leads to remission of concurrent type 2 diabetes mellitus (T2DM), even before body weight loss takes place. This is probably based on the correction of a dysmetabolic cyc...
PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses [0.03%]
PCSK9和ANGPTL3水平与HIV脂代谢异常有关，受禁食影响，而不会受到生理或药理剂量瘦素的影响
Eirini Bouzoni,Nikolaos Perakakis,Margery A Connelly et al.
Eirini Bouzoni et al.
Background: Medications leveraging the leptin, PCSK9, ANGPTL3 and FABP4 pathways are being developed for the treatment of insulin resistance and/or lipid disorders. To evaluate whether these pathways are independent from ...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Sep:134:155265. DOI:10.1016/j.metabol.2022.155265 2022
Comprehensive molecular mechanisms and clinical therapy in nonalcoholic steatohepatitis: An overview and current perspectives [0.03%]
非酒精性脂肪肝病的全面分子机制及临床治疗：概览与当前观点
Mengyao Yan,Shuli Man,Long Ma et al.
Mengyao Yan et al.
Our understanding of nonalcoholic steatohepatitis (NASH) pathophysiology continues to advance rapidly. Given the complexity of the pathogenesis of NASH, the field has moved from describing the single pathogenesis of NASH to deeply phenotypi...
Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: A systematic review based on proteomic findings [0.03%]
基于蛋白质组学发现的抗肿瘤药物诱导心脏毒性的分子靶点的系统评价及Meta分析
Sofia Reis Brandão,Félix Carvalho,Francisco Amado et al.
Sofia Reis Brandão et al.
Several anticancer agents have been associated with cardiac toxic effects. The currently proposed mechanisms to explain cardiotoxicity differ among anticancer agents, but in fact, the specific modulation is not completely elucidated. Thus, ...
Recent guidelines for Non-Alcoholic Fatty Liver disease (NAFLD)/ Fatty Liver Disease (FLD): Are they already outdated and in need of supplementation? [0.03%]
最近的非酒精性脂肪肝病（NAFLD）/脂肪肝病（FLD）指南：是否会过时并需要补充？
Laura Valenzuela-Vallejo,Valentina Guatibonza-García,Christos S Mantzoros
Laura Valenzuela-Vallejo
Non-Alcoholic Fatty Liver Disease (NAFLD) is a highly prevalent disease and unmet clinical need that we have recently proposed to be renamed for simplicity and accuracy as Fatty Liver Disease (FLD), with specific subclassifications. It has ...
Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness [0.03%]
miR150敲除小鼠骨髓细胞移植改善衰老相关的体液免疫功能异常和动脉僵硬
Jun Fan,Shirley Wang,Xianglan Lu et al.
Jun Fan et al.
Background and purpose: The senescence-accelerated mouse P1 (SAMP1) suffers from humoral immune deficiency, arterial stiffness and accelerated aging. In contrast, the microRNA-150 knockout (miR-150-KO) mice show enhanced ...