Kdm6a deficiency in microglia/macrophages epigenetically silences Lcn2 expression and reduces photoreceptor dysfunction in diabetic retinopathy [0.03%]
糖尿病性视网膜病变中少突胶质细胞/巨噬细胞中的Kdm6a通过表观遗传学抑制Lcn2的表达并减少感光细胞功能障碍
Yanjun Wen,Xin Chen,Huazhang Feng et al.
Yanjun Wen et al.
Diabetic retinopathy (DR) is one of the leading causes of severe visual impairment worldwide. However, the role of adaptive immune inflammation driven by microglia/macrophages in DR is not yet well elucidated. Kdm6a is a histone demethylase...
Metformin, testosterone, or both in men with obesity and low testosterone: A double-blind, parallel-group, randomized controlled trial [0.03%]
二甲双胍、睾丸素或二者联合用于治疗肥胖且睾酮水平偏低的男性患者的一项双盲随机对照试验
José Carlos Fernández-García,Rocío Barrios-Rodríguez,Maite Asenjo-Plaza et al.
José Carlos Fernández-García et al.
Background: Men with obesity tend to be insulin resistant and often have low-normal testosterone concentrations. We conducted a clinical trial aimed to evaluate potential therapeutic strategies for low testosterone in men...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2022 Nov:136:155290. DOI:10.1016/j.metabol.2022.155290 2022
Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis [0.03%]
胰腺PCSK9通过LDLR胆固醇轴控制β细胞分泌途径的组织架构
Algerta Marku,Lorenzo Da Dalt,Alessandra Galli et al.
Algerta Marku et al.
Background: Cholesterol is central to pancreatic β-cell physiology and alterations of its homeostasis contribute to β-cell dysfunction and diabetes. Proper intracellular cholesterol levels are maintained by different me...
Potential impact of Helicobacter pylori and metabolic syndrome-related non-alcoholic fatty liver disease on cardio-cerebrovascular disease [0.03%]
幽门螺杆菌和代谢综合征相关非酒精性脂肪肝病对心脑血管疾病潜在影响的研究进展
Jannis Kountouras,Apostolis Papaefthymiou,Stergios A Polyzos et al.
Jannis Kountouras et al.
The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions [0.03%]
线粒体NAD+转运蛋白SLC25A51是一个饥饿诱导基因并影响SIRT3功能
Zhiyao Fu,Hyunbae Kim,Paul T Morse et al.
Zhiyao Fu et al.
Introduction: Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism and energy production. NAD+-dependent deacetylase sirtuin 3 (SIRT3) regulates the acetylation levels of mitochondrial proteins that...
Dong Joo Yang,Le Trung Tran,Seul Gi Yoon et al.
Dong Joo Yang et al.
Objective: Neuronal primary cilia are known to be a required organelle for energy balance and leptin action. However, whether primary cilia directly mediate adaptive responses during starvation is yet unknown. Therefore, ...
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis [0.03%]
一种针对NLRP3的siRNA的阳离子脂质体，用于调节LDL转胞吞作用以治疗实验性动脉粥样硬化的新方法
Xiong Jia,Xiangli Bai,Xiaoyan Yang et al.
Xiong Jia et al.
Background: Activation of NLRP3 inflammasome accelerates the formation of atherosclerotic plaques. Here, we evaluated the effects of inflammation on the expression of the NLRP3 inflammasome in endothelial cells (ECs). ...
CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status [0.03%]
趋化因子CX3CL1/CX3CR1相互作用通过调节巨噬细胞迁移和M1/M2状态抵抗脂毒性诱导的非酒精性脂肪肝病
Yinhua Ni,Fen Zhuge,Liyang Ni et al.
Yinhua Ni et al.
Background and objectives: Chemokine (C-X3-C motif) ligand 1 (CX3CL1) and its receptor CX3CR1 regulate the migration and activation of immune cells and are involved in the pathogenesis of nonalcoholic steatohepatitis (NAS...
Androgen receptor functions in pericentral hepatocytes to decrease gluconeogenesis and avoid hyperglycemia and obesity in male mice [0.03%]
雄性小鼠肝细胞中雄激素受体通过减少糖异生作用以避免高血糖和肥胖症
Kai-Wei Chen,Yu-Shan Chen,Pei-Jer Chen et al.
Kai-Wei Chen et al.
Background: Although the impact of hepatic androgen receptor (AR) pathway on liver pathogenesis was documented, its physiological function in normal liver is remained unclear. This study aims to investigate if hepatic AR ...
Dissecting causal relationships between nonalcoholic fatty liver disease proxied by chronically elevated alanine transaminase levels and 34 extrahepatic diseases [0.03%]
非酒精性脂肪肝病（以丙氨酸氨基转移酶水平持续升高代理）与34种肝外疾病的因果关系研究
Zhenqiu Liu,Chen Suo,Hong Fan et al.
Zhenqiu Liu et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide and is associated with the risk of many extrahepatic diseases. However, whether NAFLD is a risk marker or a common cause of extrahepatic diseases...