Mitochondrial quality control mechanisms as molecular targets in diabetic heart [0.03%]
糖尿病心脏线粒体质量控制机制分子靶点研究进展
Xing Chang,Yukun Li,Chen Cai et al.
Xing Chang et al.
Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In addition to their canonical metabolic actions, mitochondria influence various other aspects of cardiomyocyte function, including oxidative stress, iron...
Increased risk of incident diabetes after therapy with immune checkpoint inhibitor compared with conventional chemotherapy: A longitudinal trajectory analysis using a tertiary care hospital database [0.03%]
与常规化疗相比，免疫检查点抑制剂治疗后发生糖尿病的风险增加：使用三级护理医院数据库进行的纵向轨迹分析
Minyoung Lee,Kyeongseob Jeong,Yu Rang Park et al.
Minyoung Lee et al.
Aims/hypothesis: Immune checkpoint inhibitor (ICI) has been emerged as a promising cancer treatment. However, ICI use induces immune-related adverse events, including diabetes mellitus. We compared the risk of new-onset d...
Changes in circulating bile acid subtypes in response to weight-loss diets are associated with improvements in glycemic status and insulin resistance: The POUNDS Lost trial [0.03%]
循环胆汁酸亚型对体重减轻饮食的反应与糖代谢状态和胰岛素抵抗改善相关：POUNDS LOSS试验结果
Yoriko Heianza,Xuan Wang,Jennifer Rood et al.
Yoriko Heianza et al.
Objective: Various primary and secondary bile acids (BAs) may play pivotal roles in glucose/insulin metabolism. We investigated whether changes in specific BA subtypes were associated with long-term changes in glucose and...
Sodium-glucose cotransporter-2 inhibitors: A treatment option for recurrent vasovagal syndrome? [0.03%]
钠葡萄糖共转运蛋白-2抑制剂可作为反复发作性血管迷走性晕厥的治疗选择吗？
Despina Sanoudou,Christos S Mantzoros,Michael A Hill
Despina Sanoudou
Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat [0.03%]
复发性低血糖增加大鼠肝脏糖异生而不影响肝糖原代谢和全身脂解作用
Zejian Liu,Lingyu Zhang,Chen Qian et al.
Zejian Liu et al.
Introduction: Recurrent hypoglycemia (RH) impairs secretion of counterregulatory hormones. Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory hormones are poorly und...
Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification [0.03%]
脂肪组织与死亡率的关系：孟德尔随机化和生活方式改善的分析
Jinbo Hu,Xiangjun Chen,Jun Yang et al.
Jinbo Hu et al.
Background: The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on Mendelian randomization (MR) analysis and lifestyl...
Joint effect of blood pressure and glycemic variation on the risk of cardiovascular morbidity and mortality in persons with type 2 diabetes [0.03%]
血压波动与血糖变异值对2型糖尿病患者的心血管疾病风险的联合效应研究
Cheng-Chieh Lin,Chia-Ing Li,Ya-Ling Juan et al.
Cheng-Chieh Lin et al.
Objective: Few studies have explored the association of visit-to-visit variation in blood pressure (BP) and glycemic factors with cardiovascular disease (CVD) morbidity and mortality. This study aimed to examine the indep...
Dysregulated adipose tissue expansion and impaired adipogenesis in Prader-Willi syndrome children before obesity-onset [0.03%]
普瑞德威利症候群儿童肥胖发生前脂肪组织扩张异常及脂质生成受损
Yunqi Chao,Lei Gao,Xiangzhi Wang et al.
Yunqi Chao et al.
Objective: Prader-Willi syndrome (PWS) is a rare genetic imprinting disorder resulting from the expression loss of genes on the paternally inherited chromosome 15q11-13. Early-onset life-thriving obesity and hyperphagia r...
Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis [0.03%]
伊米普仑通过激活FAM3A-FOXA2-CPT2通路改善肝脏脂质蓄积
Xiangyang Liu,Song Hou,Rui Xiang et al.
Xiangyang Liu et al.
Mitochondrial FAM3A has been revealed to be a viable target for treating diabetes and nonalcoholic fatty liver disease (NAFLD). However, its distinct mechanism in ameliorating hepatic steatosis remained unrevealed. High-throughput RNA seque...
Novel metabolic classification for extrahepatic complication of metabolic associated fatty liver disease: A data-driven cluster analysis with international validation [0.03%]
基于数据驱动聚类分析的代谢相关性脂肪肝病合并 excess hepatic 复杂疾病的新型代谢分类：国际多中心验证研究
Junzhao Ye,Xiaodong Zhuang,Xin Li et al.
Junzhao Ye et al.
Background: Traditional classification systems of metabolic-associated fatty liver disease (MAFLD) do not account for the high rate of extrahepatic complications. To create a new classification of MAFLD using metabolic pa...