Long noncoding TSI attenuates aortic valve calcification by suppressing TGF-β1-induced osteoblastic differentiation of valve interstitial cells [0.03%]
长链非编码RNA TSI通过抑制转化生长因子β1诱导的瓣膜间质细胞成骨分化来减缓主动脉瓣钙化
Zongtao Liu,Yixuan Wang,Fayuan Liu et al.
Zongtao Liu et al.
Introduction: Calcific aortic valve disease (CAVD) is an active and cellular-driven fibrocalcific process characterised by differentiation of valve interstitial cells (VICs) towards an osteogenic-like phenotype. A recentl...
Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight [0.03%]
奥氮平通过调节下丘脑AMPK磷酸化控制能量平衡和体重
Vitor Ferreira,Cintia Folgueira,Maria Guillén et al.
Vitor Ferreira et al.
Background: Second-generation antipsychotics (SGAs) are a mainstay therapy for schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and hyperglycemia. Herein, we evaluated the effects of o...
Metabolism, Clinical and Experimental: seventy years young and growing [0.03%]
代谢、临床与实验：七十载华章续写，砥砺前行
Stergios A Polyzos,Michael A Hill,Ghada El-Hajj Fuleihan et al.
Stergios A Polyzos et al.
Antea DeMarsilis,Niyoti Reddy,Chrysoula Boutari et al.
Antea DeMarsilis et al.
Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and social impact for which multiple conventional and novel pharmacotherapies are currently available; however, the landscape of T2D treatment is constantly chang...
Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity [0.03%]
微粒体甘油三酯转移蛋白通过其脂质转运独立活性调节脂肪细胞内的脂解作用
Sujith Rajan,Peter Hofer,Amanda Christiano et al.
Sujith Rajan et al.
Background: The triglyceride (TG) transfer activity of microsomal triglyceride transfer protein (MTP) is essential for lipoprotein assembly in the liver and intestine; however, its function in adipose tissue, which does n...
Risk of incident diabetes after COVID-19 infection: A systematic review and meta-analysis [0.03%]
COVID-19感染后的糖尿病发病风险：系统评价和荟萃分析
Honghao Lai,Manli Yang,Mingyao Sun et al.
Honghao Lai et al.
Background: COVID-19 might be a risk factor for various chronic diseases. However, the association between COVID-19 and the risk of incident diabetes remains unclear. We aimed to meta-analyze evidence on the relative risk...
Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH [0.03%]
基于全基因组关联和孟德尔随机化的纤维细胞生长因子21的基因组广泛关联与梅纳德随机化研究发现其与高血脂症以及可能的非酒精性脂肪肝具有因果关系
Susanna C Larsson,Karl Michaëlsson,Marina Mola-Caminal et al.
Susanna C Larsson et al.
Background: Fibroblast growth factor 21 (FGF21) is a hepatokine that produces metabolic benefits, such as improvements of lipid profile. We performed a genome-wide association study (GWAS) to identify genetic variants ass...
Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels [0.03%]
苯扎贝特联合他汀治疗与高甘油三酯水平的普通人群全因死亡和心血管疾病低风险相关
Kyung-Soo Kim,Sangmo Hong,Kyungdo Han et al.
Kyung-Soo Kim et al.
Background: We investigated the effects of fenofibrate add-on to statin treatment on all-cause death and cardiovascular disease (CVD) in the general population who had high triglyceride (TG). ...
Adipose tissue aging: An update on mechanisms and therapeutic strategies [0.03%]
脂肪组织衰老：机制与治疗策略的最新研究动态
Zhaohua Cai,Ben He
Zhaohua Cai
Aging is a complex biological process characterized by a progressive loss of physiological integrity and increased vulnerability to age-related diseases. Adipose tissue plays central roles in the maintenance of whole-body metabolism homeost...
Body fatness associations with cancer: evidence from recent epidemiological studies and future directions [0.03%]
近期流行病学研究中发现的体脂与癌症之间的关联及未来方向
Susanna C Larsson,Nikolaos Spyrou,Christos S Mantzoros
Susanna C Larsson
This narrative review highlights current evidence linking greater body fatness to risk of various cancers, with focus on evidence from recent large cohort studies and pooled analyses of cohort studies as well as Mendelian randomization stud...