Metabolic profile predicts incident cancer: A large-scale population study in the UK Biobank [0.03%]
代谢谱预测癌症的发生：英国生物样本库中大规模人群研究
Muktar Ahmed,Ville-Petteri Mäkinen,Amanda Lumsden et al.
Muktar Ahmed et al.
Background and aims: Analyses to predict the risk of cancer typically focus on single biomarkers, which do not capture their complex interrelations. We hypothesized that the use of metabolic profiles may provide new insig...
Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts [0.03%]
心律失常的磷脂酶内模体-R14del人源化小鼠心脏室腔中动作电位调节因子异构体的变化
Malgorzata E Rogalska,Elizabeth Vafiadaki,Zoi Erpapazoglou et al.
Malgorzata E Rogalska et al.
Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular arrhythmias and sudden cardiac death and affects hundreds of thousands of patients worldwide. The deletion of Arginine 14 (p.R14del) in the phospholamban (...
Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity [0.03%]
肥胖医学和外科治疗对代谢组学，脂肪和脂蛋白的早期改变
Angeliki M Angelidi,Alexander Kokkinos,Despina Sanoudou et al.
Angeliki M Angelidi et al.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) and bariatric surgery have proven to be effective treatments for obesity and cardiometabolic conditions. We aimed to explore the early metabolomic changes in...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2023 Jan:138:155346. DOI:10.1016/j.metabol.2022.155346 2023
Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases [0.03%]
Resistin通过环腺苷酸相关蛋白1介导的分裂作用损害线粒体稳态，导致肥胖诱导的代谢疾病
Han-Mo Yang,Joonoh Kim,Dasom Shin et al.
Han-Mo Yang et al.
Objective: One of the suggested mechanisms of obesity-induced insulin resistance is mitochondrial dysfunction in target tissues such as skeletal muscle. In our study, we examined whether resistin, an adipokine associated ...
Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis [0.03%]
长链酰基辅酶A合成酶1的丧失促进酒精性脂肪性肝炎中的肝细胞死亡
Haibo Dong,Wei Zhong,Wenliang Zhang et al.
Haibo Dong et al.
Background: Alcohol consumption has been shown to disrupt hepatic lipid homeostasis. Long-chain acyl-CoA synthetase 1 (ACSL1) critically regulates hepatic fatty acid metabolism and lipid homeostasis by channeling fatty ac...
Hypothalamic integrity is necessary for sustained weight loss after bariatric surgery: A prospective, cross-sectional study [0.03%]
下丘脑完整性对于减肥手术后维持体重减轻是必要的：一项前瞻性、横断面研究
Ulrich Dischinger,Laura Kötzner,Petia Kovatcheva-Datchary et al.
Ulrich Dischinger et al.
Objective: The hypothalamus is the main integrator of peripheral and central signals in the control of energy homeostasis. Its functional relevance for the effectivity of bariatric surgery is not entirely elucidated. Stud...
Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization [0.03%]
DPP4的非酶功能通过IGF-2R/PKA/SP1/ERp29/IP3R2通路介导的Treg功能障碍和M1小胶质细胞极化促进糖尿病相关的认知功能障碍
Ya Hui,Zhiqiang Xu,Jiaxiu Li et al.
Ya Hui et al.
Background: Impairment of regulatory T (Treg) cells function is implicated in the pathogenesis of immune imbalance-mediated cognitive impairment. A complete understanding of whether and how this imbalance affect cognitive...
Mitochondrial adaptations to calorie restriction and bariatric surgery in human skeletal muscle: a systematic review with meta-analysis [0.03%]
人类骨骼肌中卡路里限制和代谢手术对线粒体的影响：系统回顾与荟萃分析
Miguel Pérez-Rodríguez,Jesús R Huertas,José M Villalba et al.
Miguel Pérez-Rodríguez et al.
Objective: We performed a meta-analysis to determine the changes induced by calorie restriction (CR) and bariatric surgery on human skeletal muscle mitochondria. ...
Downregulation of the m6A reader protein YTHDC1 leads to islet β-cell failure and diabetes [0.03%]
m6A“阅读蛋白”YTHDC1下调导致胰岛β细胞功能障碍及糖尿病
Xinzhi Li,Ying Yang,Zheng Chen
Xinzhi Li
N6-methyladenosine (m6A) methyltransferase writer proteins (METTL3/METTL14) have been shown to regulate β-cell function and diabetes. However, whether and which m6A reader proteins regulate β-cell function and the pathogenesis of diabetes...
Prajna Udupa,Abhishek Kumar,Rahul Parit et al.
Prajna Udupa et al.
Background: Homeostasis of autophagy under normal conditions and nutrient stress is maintained by adaptive activation of regulatory proteins. However, the protein-lipid crosstalk that modulates the switch from suppression...