ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease [0.03%]
ABCA1缺乏介导的肾小球胆固醇蓄积加剧了糖尿病肾病中的肾小球内皮损伤和功能障碍
Junlin Zhang,Yucheng Wu,Jie Zhang et al.
Junlin Zhang et al.
Background: Hyperglycemia and dyslipidemia are two major characteristics of diabetes. In this study, the effects of glomerular cholesterol accumulation primarily due to ABCA1 deficiency on glomerular endothelial injury in...
Glucagon-like peptide-1 secretion in people with versus without type 2 diabetes: a systematic review and meta-analysis of cross-sectional studies [0.03%]
二型糖尿病患者与非二型糖尿病患者的胰高血糖素样肽-1分泌：一项横断面研究的系统回顾及荟萃分析
J D Watkins,S Carter,G Atkinson et al.
J D Watkins et al.
Aims/hypothesis: The aim of this systematic review was to synthesise the study findings on whether GLP-1 secretion in response to a meal tolerance test is affected by the presence of type 2 diabetes (T2D). The influence o...
FAM3A maintains metabolic homeostasis by interacting with F1-ATP synthase to regulate the activity and assembly of ATP synthase [0.03%]
通过与F1-ATP合成酶相互作用来调节ATP合成酶的活性和组装以维持代谢稳态的FAM3A
Han Yan,Yuhong Meng,Xin Li et al.
Han Yan et al.
Reduced mitochondrial ATP synthase (ATPS) capacity plays crucial roles in the pathogenesis of metabolic disorders. However, there is currently no effective strategy for synchronously stimulating the expressions of ATPS key subunits to resto...
Impaired hepatic glucose metabolism and liver-α-cell axis in mice with liver-specific ablation of the Hepatocyte Nuclear Factor 4α (Hnf4a) gene [0.03%]
肝细胞核因子4α (Hnf4a)基因在肝脏特异性缺失小鼠中的受损肝糖代谢和肝-α细胞轴
Efstathia Thymiakou,Maria Tzardi,Dimitris Kardassis
Efstathia Thymiakou
Background: Hnf4a gene ablation in mouse liver causes hepatic steatosis, perturbs HDL structure and function and affects many pathways and genes related to glucose metabolism. Our aim here was to investigate the role of l...
Hepatic fat as a novel marker for high-risk coronary atherosclerotic plaque features in familial hypercholesterolaemia [0.03%]
肝脂肪作为家族性高胆固醇血症患者高危冠状动脉粥样硬化斑块的新标志物
Gavin Huangfu,Biyanka Jaltotage,Jing Pang et al.
Gavin Huangfu et al.
Background & aims: Hepatic steatosis has been associated with increased risk of coronary artery disease. Individuals with familial hypercholesterolaemia have accelerated but variable progression of coronary artery disease...
SUMOylation of ERp44 enhances Ero1α ER retention contributing to the pathogenesis of obesity and insulin resistance [0.03%]
ERp44的SUMOylation通过增强Ero1α的内质网滞留来促进肥胖和胰岛素抵抗的发生发展
Hao Xie,Yu-Han Wang,Xin Liu et al.
Hao Xie et al.
Objective: As the only E2 conjugating enzyme for the SUMO system, Ubc9-mediated SUMOylation has been recognized to regulate diverse biological processes, but its impact on adipocytes relevant to obesity and insulin resist...
Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice [0.03%]
垂体AMPKα1的小型细胞外囊泡定位促进瘦素受体缺乏小鼠的体重减轻
Edward Milbank,Nathalia Dragano,Xavi Vidal-Gómez et al.
Edward Milbank et al.
Background and aims: Leptin receptor (LEPR) deficiency promotes severe obesity and metabolic disorders. However, the current therapeutic options against this syndrome are scarce. ...
Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines [0.03%]
心力衰竭中骨骼肌病和运动训练的再认识：肌肉因子的作用逐渐显现
Robinson Ramírez-Vélez,Arantxa González,Antonio García-Hermoso et al.
Robinson Ramírez-Vélez et al.
Exercise intolerance remains a major unmet medical need in patients with heart failure (HF). Skeletal myopathy is currently considered as the major limiting factor for exercise capacity in HF patients. On the other hand, emerging evidence s...
Corrigendum to "The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans" [Metab. 97 (2019) 40-49] [0.03%]
《RNA结合蛋白HuR影响啮齿动物和人类的骨骼肌代谢灵活性》[代谢。97（2019）40-49]的勘误表
Randall L Mynatt,Robert C Noland,Carrie M Elks et al.
Randall L Mynatt et al.
Circulating lipoprotein(a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses [0.03%]
循环脂蛋白（a）水平与健康结果：全表型组孟德尔随机化和疾病轨迹分析
Susanna C Larsson,Lijuan Wang,Xue Li et al.
Susanna C Larsson et al.
Background: Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic and valvular diseases, but its possible role in other diseases has not yet been established. We conducted phenome-wide Mendelian randomization and di...