Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation [0.03%]
二甲双胍通过激活Akt/mTOR与间充质细胞协调作用，促进糖尿病伤口愈合中的VEGF介导的血管生成
Fangzhou Du,Mengmeng Liu,Jingwen Wang et al.
Fangzhou Du et al.
Introduction: Cell therapy with mesenchymal stem cells (MSCs) and biomaterials holds great potential for the treatment of diabetic ulceration; however, the underlying mechanism as well as its compatibility with the first-...
TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury [0.03%]
TMBIM6通过阻止VDAC1多聚化并提高线粒体质量控制来减少脓毒症相关的心肌损伤
Hao Zhou,Zhe Dai,Jialei Li et al.
Hao Zhou et al.
Background: The regulatory mechanisms involved in mitochondrial quality control (MQC) dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized. Transmembrane BAX inhibitor motif containing 6 (TMBIM...
Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial [0.03%]
钠-葡萄糖共转运蛋白2抑制剂达帕格列净对糖尿病前期胰岛素抵抗个体的物质代谢的影响：一项随机双盲交叉试验
Anna Veelen,Charlotte Andriessen,Yvo Op den Kamp et al.
Anna Veelen et al.
Aims/hypothesis: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment in type 2 diabetes mellitus patients results in glucosuria, causing an energy loss, and triggers beneficial metabolic adaptations. It is so far ...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2023 Mar:140:155396. DOI:10.1016/j.metabol.2022.155396 2023
Activins, follistatins and inhibins in postmenopausal osteoporosis: A proof of concept, case-control study [0.03%]
活化素、卵泡抑素和抑制素在绝经后骨质疏松症中的作用：一项验证性病例对照研究
Athanasios D Anastasilakis,Stergios A Polyzos,Nikolaos E Rodopaios et al.
Athanasios D Anastasilakis et al.
Background: Bone metabolism has been proposed to be affected by the activins-follistatins-inhibins (AFI) hormonal system. We aimed to evaluate AFI in patients with osteoporosis and osteopenia compared with postmenopausal ...
Relationship between circulating adipokines and cholesterol efflux in subjects with severe carotid atherosclerosis [0.03%]
严重颈动脉粥样硬化患者循环型脂肪细胞因子和胆固醇外流之间的关系
Karina Gasbarrino,Anouar Hafiane,Ioanna Gianopoulos et al.
Karina Gasbarrino et al.
Aims: Cholesterol efflux capacity (CEC) as a measure of high-density lipoprotein functionality is independently and inversely associated with increased risk of cardiovascular events and mortality, and advanced plaque morp...
Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes [0.03%]
使用[18F]FDG-PET评估肾葡萄糖摄取：方法学进步和代谢结果
Eleni Rebelos,Andrea Mari,Vesa Oikonen et al.
Eleni Rebelos et al.
Background/purpose: Studying renal glucose metabolism non-invasively in humans is an unmet need. Positron emission tomography (PET) is the current gold standard for measuring regional tissue glucose uptake rates, but the ...
Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway [0.03%]
肝细胞Ninjrin2通过IGF1R/EGR1/PDGF-BB信号通路促进肝星状细胞激活及肝纤维化
Yifan Wang,Pengyun Wang,Yubing Yu et al.
Yifan Wang et al.
Background: Liver fibrogenesis is orchestrated by the paracrine signaling interaction between several resident cell types regulating the activation of hepatic stellate cells (HSCs). However, the molecular mechanisms under...
Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis [0.03%]
脂肪组织的脂肪素和脂因子：在骨骼肌发育及自稳态中的功能及其调节机制
Xin Gu,Liyi Wang,Shiqi Liu et al.
Xin Gu et al.
Skeletal muscle plays important roles in normal biological activities and whole-body energy homeostasis in humans. The growth and development of skeletal muscle also directly influence meat production and meat quality in animal production. ...
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis [0.03%]
Fyn的缺乏通过减少c-Cbl介导的Sirt1泛素化来抑制氧化应激，从而减轻糖尿病性肾纤维化
Shanshan Li,Zeyuan Lin,Haiming Xiao et al.
Shanshan Li et al.
Objective: Oxidative stress (OS) is the main cause leading to diabetic renal fibrosis. Recently, Fyn was paid much attention on OS and emerged as a pivotal player in acute kidney injury, while whether Fyn regulates oxidat...
Inhibition of S100A8/A9 ameliorates renal interstitial fibrosis in diabetic nephropathy [0.03%]
S100A8/A9的抑制可减轻糖尿病肾病的肾间质纤维化
Lei Du,Yibing Chen,Jiasen Shi et al.
Lei Du et al.
Background: Renal interstitial fibrosis (RIF) is one of the main features of diabetic nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully understood. S100A8 and S100A9 are the proteins as...