Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders [0.03%]
靶向脂肪细胞结合蛋白FABP4可改善老年小鼠肝代谢及衰老相关代谢紊乱
Jian Lv,Yimeng Hu,Lili Li et al.
Jian Lv et al.
Introduction: Aging is characterized by progressive metabolic dyshomeostasis that increases morbidity and mortality. Solutions for optimizing healthy aging are challenged by lacking appropriate biomarkers. Moreover, drugg...
Folate metabolism negatively regulates OAS-mediated antiviral innate immunity via ADAR3/endogenous dsRNA pathway [0.03%]
叶酸代谢通过ADAR3/内源性dsRNA信号抑制OAS介导的抗病毒天然免疫反应
Jing Wu,Qiao You,Ruining Lyu et al.
Jing Wu et al.
Background: Folate (FA) is an essential cofactor in the one-carbon (1C) metabolic pathway and participates in amino acid metabolism, purine and thymidylate synthesis, and DNA methylation. FA metabolism has been reported t...
Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis [0.03%]
二甲双胍诱导的TTP介导枯氏细胞与肝细胞通讯通过调节脂自噬和坏死性凋亡缓解肝脏脂肪变性
Jeongmin Park,So-Young Rah,Hyeong Seok An et al.
Jeongmin Park et al.
Objective: Emerging evidence suggests that crosstalk between Kupffer cells (KCs) and hepatocytes protects against non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms that lead to the reduction of...
Subtypes of type 2 diabetes and their association with outcomes in Korean adults - A cluster analysis of community-based prospective cohort [0.03%]
韩国成人基于社区的前瞻性队列中2型糖尿病亚型及其与预后的关联-聚类分析结果
You-Cheol Hwang,Hong-Yup Ahn,Ji Eun Jun et al.
You-Cheol Hwang et al.
Background: Little is known about the subtypes of type 2 diabetes (T2D) and their association with clinical outcomes in Asians. Methods: ...
Chronic physiologic hyperglycemia impairs insulin-mediated suppression of plasma glucagon concentration in healthy humans [0.03%]
慢性生理高血糖损害健康人体内胰岛素介导的血浆胰高糖素浓度抑制作用
Xi Chen,Aurora Merovci,Ralph A DeFronzo et al.
Xi Chen et al.
Background and aims: Hyperglucagonemia is a characteristic feature of type 2 diabetes mellitus (T2DM). We examined the effect of chronic (48-72 h) physiologic increase (+50 mg/dl) in plasma glucose concentration on suppre...
Early humoral response to COVID-19 vaccination in patients living with obesity and diabetes in France. The COVPOP OBEDIAB study with results from the ANRS0001S COV-POPART cohort [0.03%]
法国肥胖和糖尿病患者接种新冠疫苗后的早期免疫反应。COVPOP OBEDIAB研究及ANRS0001S COV-POPART队列结果报告
Bénédicte Gaborit,Sara Fernandes,Paul Loubet et al.
Bénédicte Gaborit et al.
Background: Patients with diabetes and obesity are populations at high-risk for severe COVID-19 outcomes and have shown blunted immune responses when administered different vaccines. Here we used the 'ANRS0001S COV-POPART...
The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000-2019 [0.03%]
全球代谢性疾病年轻成年人群体流行态势：来自2000—2019年全球疾病负担研究的趋势及预测报告
Bryan Chong,Gwyneth Kong,Kannan Shankar et al.
Bryan Chong et al.
Background: A significant proportion of premature deaths globally are related to metabolic diseases in young adults. We examined the global trends and mortality of metabolic diseases in individuals aged below 40 years usi...
Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis [0.03%]
全面氨基酸通量分析测定的女性对危重病的代谢反应不同
Nicolaas E P Deutz,Pierre Singer,Raven A Wierzchowska-McNew et al.
Nicolaas E P Deutz et al.
Background: The trajectory from healthy to critical illness is influenced by numerous factors, including metabolism, which differs substantially between males and females. Whole body protein breakdown is substantially inc...
Adherence to the EAT-Lancet diet, genetic susceptibility, and risk of type 2 diabetes in Swedish adults [0.03%]
遵循EAT-Lancet饮食、遗传易感性和瑞典成年人二型糖尿病的风险
Shunming Zhang,Anna Stubbendorff,Kjell Olsson et al.
Shunming Zhang et al.
Background and aims: In 2019, the EAT-Lancet Commission proposed a mainly plant-based diet that nurtures human health and supports environmental sustainability. However, its association with type 2 diabetes (T2D) has not ...
Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD [0.03%]
新的稳定示踪脉冲方法评估身体易接触和不易接触区域的短链脂肪酸生成，发现其产量随年龄增长而减少，且与慢阻肺的存在无关
Sarah K Kirschner,Parisa Ghane,Jaekwan K Park et al.
Sarah K Kirschner et al.
Background: Production rates of the short-chain fatty acids (SCFA) acetate, propionate, and butyrate, which are beneficial metabolites of the intestinal microbiota, are difficult to measure in humans due to inaccessibilit...
Observational Study
Metabolism: clinical and experimental. 2023 Apr:141:155399. DOI:10.1016/j.metabol.2023.155399 2023