Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice [0.03%]
肝型单羧酸转运蛋白1通过调节小鼠高脂饮食诱导的肥胖和肝脂肪变性发挥作用
Xuemei Luo,Zixuan Li,Lingling Chen et al.
Xuemei Luo et al.
Background: The monocarboxylate transporter 1 (MCT1) is a member of the MCT family and is implicated in the transport of lactate and a few other monocarboxylates across the cell membrane. How hepatic MCT1 regulates the me...
Involvement of a novel cAMP signaling mediator for beige adipogenesis [0.03%]
新型cAMP信号分子介导贝格细胞分化的作用机制研究
Jun Seok Kim,Hye-Sook Han,Je Kyung Seong et al.
Jun Seok Kim et al.
Background: Exposure to cold temperature stimulates the sympathetic nervous system that activates β-adrenergic receptor signals in brown and beige adipocytes, leading to the induction of adaptive thermogenesis in mammals...
Increased meal-induced neurotensin response predicts successful maintenance of weight loss - Data from a randomized controlled trial [0.03%]
餐后内皮素反应增强预示体重减轻成功维持——来自一项随机对照试验的数据
Annemette Overgaard Brethvad,Hannah Louise Zakariassen,Joachim Holt et al.
Annemette Overgaard Brethvad et al.
Background: The gut derived anorexigenic hormone neurotensin (NT) is upregulated after bariatric surgery which may contribute to the sustained weight loss. In contrast, diet-induced weight loss is most often followed by w...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2023 Jun:143:155534. DOI:10.1016/j.metabol.2023.155534 2023
The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis [0.03%]
循环纤维生长因子21水平与新发心力衰竭事件的关联：动脉粥样硬化多元民族研究结果
William Tucker,Robyn L McClelland,Matthew A Allison et al.
William Tucker et al.
Background: Fibroblast growth factor 21 (FGF21) levels are often elevated in heart failure (HF), although this has not been assessed using a longitudinal study design. Therefore, we investigated the association between ba...
Shuai Yuan,Susanna C Larsson
Shuai Yuan
Sarcopenia is a geriatric condition featured by a progressive loss of muscle mass and function and associated with various adverse health outcomes. In this review, we aimed to summarize the epidemiological features of sarcopenia as well as ...
The role of histone deacetylases in cardiac energy metabolism in heart diseases [0.03%]
组蛋白去乙酰化酶在心脏疾病中对心脏能量代谢的作用
Qingwen Yu,Guangyuan Zhao,Jingjing Liu et al.
Qingwen Yu et al.
Heart diseases are associated with substantial morbidity and mortality worldwide. The underlying mechanisms and pathological changes associated with cardiac diseases are exceptionally complex. Highly active cardiomyocytes require sufficient...
TNFα-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2 [0.03%]
肿瘤坏死因子诱导的NLRP3炎性小体介导脂肪细胞功能障碍并通过脂肪细胞来源的脂联素2活化巨噬细胞
Hafiz Muhammad Ahmad Javaid,Eun Ko,Esther Jin Joo et al.
Hafiz Muhammad Ahmad Javaid et al.
Background and aims: Obesity is a state of chronic low-grade systemic inflammation. Recent studies showed that NLRP3 inflammasome initiates metabolic dysregulation in adipose tissues, primarily through activation of adipo...
Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy [0.03%]
生理学、设计和开发新型药物的进步改变了肥胖症治疗的格局
Marlene Chakhtoura,Christos S Mantzoros
Marlene Chakhtoura
Upstream and downstream regulators of Klotho expression in chronic kidney disease [0.03%]
慢性肾脏病条件下衰老相关基因Klotho的上游和下游调节因子研究
Sha-Sha Li,Ming-Jie Sheng,Zhuo-Yi Sun et al.
Sha-Sha Li et al.
Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and progression of CKD. Conversely, an increase in Klotho levels r...
Blood immune cells from people with HIV on antiviral regimens that contain tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) have differential metabolic signatures [0.03%]
含有替诺福韦阿拉芬胺(TAF)和富马酸替诺福韦二吡呋酯(TDF)抗病毒方案的人类免疫缺陷病毒感染者的血液免疫细胞具有不同的代谢特征
Eleni Ritou,Sandro Satta,Anton Petcherski et al.
Eleni Ritou et al.
Background: Mitochondria regulate immune and organ function. It is unknown whether higher intracellular drug levels observed in peripheral blood mononuclear cells (PBMCs) treated with tenofovir alafenamide (TAF) compared ...