PFKFB3 nuclear translocation improves diabetic retinopathy by attenuating endothelial cell senescence through inhibition of USP7-p53 axis [0.03%]
PFKFB3核转位通过抑制USP7-p53轴改善内皮细胞衰老及糖尿病视网膜病变
Peiyu Liu,Ning Shen,Yali Zhou et al.
Peiyu Liu et al.
Background: Endothelial cell (EC) senescence is a key contributor to retinal vascular dysfunction in diabetic retinopathy (DR), yet its molecular mechanisms remain incompletely understood. While PFKFB3 is well recognized ...
A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis [0.03%]
基于生物系统利用蛋白质组学和代谢网络推理的分析揭示了肝脏脂变的机制见解
Natalie N Atabaki,Daniel E Coral,Hugo Pomares-Millan et al.
Natalie N Atabaki et al.
Objective: To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in i...
Enduring improvements in hepatic insulin sensitivity predict sustained remission of prediabetes during a 3-year lifestyle intervention: results from the PREVIEW multinational diabetes prevention trial [0.03%]
生活方式干预3年糖尿病预防试验中持久改善的肝脏胰岛素敏感性可预测前期患者的持续缓解：PREVIEW多国糖尿病预防试验结果
Ruixin Zhu,Jie Guo,Maija Huttunen-Lenz et al.
Ruixin Zhu et al.
Background: Recent investigation advocates the use of prediabetes remission as a goal of diabetes prevention. We aimed to compare changes in metabolic markers in participants with and without sustained remission of predia...
Rising burden of MASLD and CKM syndrome in Asia: A decade of trends and future projections [0.03%]
亚洲MASLD和CKMD负担日益加重：十年来的变化趋势及未来预测
Tianqi Duo,Yun Wen,Yu Bian et al.
Tianqi Duo et al.
Objective: To analyze epidemiological trends and project the future burden of metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular-kidney-metabolic (CKM) syndrome in Asia using data from the...
Reply: From liver to vasculature: An integrated view of cardiovascular risk in hepatic steatosis [0.03%]
回信：从肝脏到血管：肝脂肪变性心血管风险的综合观点
Shady Abohashem,Midori N Torpoco Rivera,Michael T Osborne
Shady Abohashem
Efficacy and safety of sepiapterin versus sapropterin in patients with phenylketonuria: Results from the Phase 3, randomized, crossover, open-label, active-controlled AMPLIPHY trial [0.03%]
苯酮尿症患者使用Sepiapterin与Sapropterin的疗效和安全性：来自AMPLIPHY三期、随机、交叉对照、开放标签的临床试验结果
Maria Giżewska,Anita Inwood,Renáta Tyčová et al.
Maria Giżewska et al.
Aim: AMPLIPHY is the first Phase 3 study comparing sepiapterin versus sapropterin in children and adults with phenylketonuria (PKU). Methods: ...
Inter-organ crosstalk in health and cardiovascular-renal-hepatic-metabolic disease: A multidisciplinary perspective [0.03%]
器官间的交流在健康和心血管-肾脏-肝脏-代谢性疾病中的作用：多学科视角
Guanghong Jia,Christos S Mantzoros,Michael A Hill
Guanghong Jia
HMGCS2 desuccinylation modulates acetoacetate to drive tubule-macrophage inflammatory crosstalk in diabetic kidney disease [0.03%]
去琥珀酰化调节HMGCS2促进乙酸乙酯的生成以驱动糖尿病肾病中的近端小管-巨噬细胞炎症互作
Ziyue Lin,Dan Lv,He Zha et al.
Ziyue Lin et al.
Mitochondrial dysfunction in renal tubular epithelial cells (TECs) is a hallmark of diabetic kidney disease (DKD), accompanied by macrophage infiltration, yet how metabolic perturbations in TECs-macrophage driven inflammation remains unclea...
Natural polyketide enterocin inhibits ASGR1 to enhance cholesterol efflux and regulate hepatic lipid metabolism [0.03%]
天然聚酮类抗生素enterocin通过抑制ASGR1促进胆固醇流出并调节肝脏脂质代谢
Yan Liu,Jia-Hao Pang,Manru Ma et al.
Yan Liu et al.
The discovery of novel, targeted cholesterol-lowering agents holds clinical value for cardiovascular disease (CVD) prevention and management. Here, we report the isolation of a naturally occurring polyketide, enterocin, from the marine-deri...