Ganoderic acid T, a novel activator of pyruvate carboxylase, exhibits potent anti-liver cancer activity [0.03%]
新颖的丙酮酸羧化酶活化剂灵芝酸T具有强力的抗肝癌作用
Bo Lei,Mengjie Zhang,Xiangrui Shi et al.
Bo Lei et al.
Background: Ganoderic acid T (GAT), a lanostane triterpenoid isolated from the methanol extract of G. lucidum mycelia, has demonstrated potent antitumor activity against various human cancer types. However, the specific m...
Revisiting gender differences in obesity and type 2 diabetes: Response letter [0.03%]
关于肥胖和2型糖尿病的性别差异再探：回信
Amparo Galán,Francisco García-García
Amparo Galán
Response to letter to the editor regarding: "Plasma metabolite profiles of meat intake and their association with cardiovascular disease risk: A population-based study in Swedish cohorts" by Arage et al., Metabolism. 2025 Jul;168:156188 [0.03%]
关于阿拉吉等人在《代谢》杂志上发表的“肉类摄入的血浆代谢物谱及其与心血管疾病风险的关系：瑞典队列中的基于人群的研究”的社论信的回复
Getachew Arage,Koen F Dekkers,Luka Marko Rašo et al.
Getachew Arage et al.
On the misinterpretation of metabolites as causal mediators between meat intake and cardiovascular risk [0.03%]
关于代谢物被误认为是肉类摄入与心血管风险之间因果介导因素的影响
Yang Zhang,Fanwu Chi,Ren Zhu et al.
Yang Zhang et al.
Corrigendum to "Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction" [Metabolism 168 (2025) 156235] [0.03%]
关于“Eva1缺乏通过减少内脏脂肪功能障碍来预防肥胖引起的代谢紊乱”的勘误声明[ metabolism 168 (2025 ) 156235 ]
You Lee Son,Jiahui Hou,Mira Kato-Suzuki et al.
You Lee Son et al.
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression [0.03%]
趋化因子CCL20通过调节OLR1表达促进代谢紊乱相关steatohepatitis中肝细胞胆固醇沉积
Min Yin,Yan Zhang,Suosi Liu et al.
Min Yin et al.
Background & aims: Metabolic dysfunction-associated steatohepatitis (MASH) is becoming a leading driver of liver failure and transplantation. The specific pathogenic mechanisms driving MASH remain incompletely understood....
Impact of metabolic dysfunction severity in steatotic liver disease and its interaction with liver fibrosis on all-cause mortality and multiple hepatic and extra-hepatic outcomes [0.03%]
非酒精性脂肪肝代谢功能障碍严重程度及其与肝脏纤维化的相互作用对全因死亡率和多种肝内外结局的影响
Daniel J Cuthbertson,Oliver J Kennedy,Josh Bilson et al.
Daniel J Cuthbertson et al.
Background: In metabolic dysfunction-associated steatotic liver disease (MASLD) and in MASLD with alcohol consumption (MetALD), we investigated the effect of severity of metabolic dysfunction on incident major adverse liv...
Targeting SAMD1 enhances the effect of anti-PD-1 plus lenvatinib therapy in hepatocellular carcinoma by increasing ferroptosis sensitivity and immune response [0.03%]
靶向SAMD1通过增加铁死亡敏感性和免疫反应增强抗PD-1联合仑伐替尼治疗肝细胞癌的效果
Guo-Qiang Pan,Yu-Chuan Yan,Rui-Zhe Li et al.
Guo-Qiang Pan et al.
Background: Combination therapy of anti-PD-1 plus lenvatinib has shown effective anti-tumour effects for unresectable hepatocellular carcinoma (HCC), but the overall prognosis of HCC is still unsatisfactory. Elucidating t...
Exploring the interplay of genetic variants and environmental factors in childhood obesity: A systematic review and meta-analysis [0.03%]
遗传变异和环境因素在儿童肥胖症中的相互作用：系统回顾和荟萃分析
Haoxue Zhu,Xinghao Yi,Mengyu He et al.
Haoxue Zhu et al.
Dynamic interactions between genetic predispositions and environmental exposures significantly shape the escalating prevalence of childhood obesity. This systematic review synthesizes observational and clinical trial evidence on the gene-en...