Exercise alleviates neovascular age-related macular degeneration by inhibiting AIM2 inflammasome in myeloid cells [0.03%]
运动通过抑制髓系细胞中AIM2炎症小体来缓解年龄相关性黄斑变性中的新生血管生成
Bohao Cui,Xu Guo,Wei Zhou et al.
Bohao Cui et al.
The neovascular form of age-related macular degeneration (nvAMD) is the leading cause of blindness in the elderly population. Vascular endothelial growth factor (VEGF) plays a crucial role in choroidal neovascularization (CNV), and anti-VEG...
Loss of metabolic adaptation in lean MAFLD is driven by endotoxemia leading to epigenetic reprogramming [0.03%]
代谢适应丧失驱动苗条的MAFLD患者内毒素血症导致表观遗传重编程
Jawaher Alharthi,Ziyan Pan,Brian S Gloss et al.
Jawaher Alharthi et al.
Lean patients with MAFLD have an initial adaptive metabolic response characterised by increased serum bile acids and Farnesoid X Receptor (FXR) activity. How this adaptive response wanes resulting in an equal or perhaps worse long-term adve...
Min Jeong Park,Kyung Mook Choi
Min Jeong Park
Sarcopenic obesity is becoming a global health concern, owing to the rising older population, causing cardiometabolic morbidity and mortality. Loss of muscle exceeding normal age-related changes has been revealed to be associated with obesi...
DR region of NKAα1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice [0.03%]
DR区是肥胖小鼠改善肝脏脂代谢障碍的新靶点
Hai-Jian Sun,Jian-Xin Tan,Xiao-Dong Shan et al.
Hai-Jian Sun et al.
Background: Na+/K+-ATPase (NKA), an ion pumping enzyme ubiquitously expressed in various cells, is critically involved in cellular ion homeostasis and signal transduction. However, the role of NKA in hepatic lipid homeost...
Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility [0.03%]
剖析KNDy假说：KNDy神经元衍生的亲吻肽对于青春期的启动可有可无，但对于维持女性生育力和促性腺激素脉冲释放至关重要
Inmaculada Velasco,Delphine Franssen,Silvia Daza-Dueñas et al.
Inmaculada Velasco et al.
Background: Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co-express neurokinin B (NKB; encoded by T...
Neutrophil aging exacerbates high fat diet induced metabolic alterations [0.03%]
中性粒细胞衰老加重高脂饮食诱导的代谢改变
Andrea Baragetti,Lorenzo Da Dalt,Annalisa Moregola et al.
Andrea Baragetti et al.
Background: High fat diet (HFD) chronically hyper-activates the myeloid cell precursors, but whether it affects the neutrophil aging is unknown. Purpose: ...
Association between diabetes and thiamine status - A systematic review and meta-analysis [0.03%]
糖尿病与硫胺素状态的关联—系统综述和荟萃分析
Dan Ziegler,Karlheinz Reiners,Alexander Strom et al.
Dan Ziegler et al.
Background: Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine status is lower in individuals with diabetes compared to individuals with normal glucose metabolism...
Harrison T Muturi,Hilda E Ghadieh,Raziyeh Abdolahipour et al.
Harrison T Muturi et al.
Objectives: Hepatocytic CEACAM1 plays a critical role in NASH pathogenesis, as bolstered by the development of insulin resistance, visceral obesity, steatohepatitis and fibrosis in mice with global Ceacam1 (Cc1) deletion....
MLX plays a key role in lipid and glucose metabolism in humans: Evidence from in vitro and in vivo studies [0.03%]
MLX在人类脂质和糖代谢中起关键作用：来自体外和体内研究的证据
Shilpa R Nagarajan,Eilidh J Livingstone,Thomas Monfeuga et al.
Shilpa R Nagarajan et al.
Background and aim: Enhanced hepatic de novo lipogenesis (DNL) has been proposed as an underlying mechanism for the development of NAFLD and insulin resistance. Max-like protein factor X (MLX) acts as a heterodimer bindin...
Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes [0.03%]
APOO（MIC26）丢失通过PPARα介导的线粒体和过氧化物酶体之间的功能相互作用加剧肥胖相关的棕色脂肪组织褐变
Xin Guo,Jiarui Hu,Guangxu He et al.
Xin Guo et al.
Background: Mitochondrial dysfunction and aberrant structure in adipose tissue occur in obesity and obesity-linked brown adipose tissue (BAT) whitening; however, whether this aberrant architecture contributes to or is the...